Social interaction following prepubertal stress alters prefrontal gene expression associated with cell signalling and oligodendrocytes

Autor: Anna L. Moon, Nicholas E. Clifton, Natalie Wellard, Kerrie L. Thomas, Jeremy Hall, Nichola M. Brydges

Publikováno v: Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)

Abstract Early-life adversity is associated with an increased risk of psychopathology, including mood disorders, later in life. Early-life stress affects several physiological systems, however, the exact mechanisms underlying pathological risk are no

Externí odkaz: https://doaj.org/article/8627372714224ffa8b2e5abf74ae4e57

Environmental enrichment rescues survival and function of adult-born neurons following early life stress

Autor: Lowenna Rule, Jeremy Hall, Nichola M. Brydges, Jessica Yang, Holly Watkin

Publikováno v: Molecular Psychiatry. 26:1898-1908

Adverse experiences early in life are associated with the development of psychiatric illnesses. The hippocampus is likely to play pivotal role in generating these effects: it undergoes significant development during childhood and is extremely reactiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3407130b85e7cfce184d55cfda62578
https://doi.org/10.1038/s41380-020-0718-4

Childhood stress impairs social function through AVP-dependent mechanisms

Autor: Holly Watkin, Catrin Lewis, Jeremy Hall, Caroline Best, Kerrie L. Thomas, Lowenna Rule, Amanda J. Drake, Nichola M. Brydges, Jessica Hall

Publikováno v: Translational Psychiatry, Vol 9, Iss 1, Pp 1-12 (2019)
Brydges, N, Hall, J, Best, C, Rule, L, Watkin, H, Drake, A, Lewis, C, Thomas, K L & Hall, J 2019, ' Childhood stress impairs social function through AVP-dependent mechanisms ', Translational Psychiatry . https://doi.org/10.1038/s41398-019-0678-0
Translational Psychiatry

Impaired social function is a core feature of many psychiatric illnesses. Adverse experiences during childhood increase risk for mental illness, however it is currently unclear whether stress early in life plays a direct role in the development of so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb07be1eca0394bfb5b51ff150bdc1e
http://link.springer.com/article/10.1038/s41398-019-0678-0

Imaging conditioned fear circuitry using awake rodent fMRI.

Autor: Nichola M Brydges, Heather C Whalley, Maurits A Jansen, Gavin D Merrifield, Emma R Wood, Stephen M Lawrie, Sara-Madge Wynne, Mark Day, Sue Fleetwood-Walker, Douglas Steele, Ian Marshall, Jeremy Hall, Megan C Holmes

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e54197 (2013)

Functional magnetic resonance imaging (fMRI) is a powerful method for exploring emotional and cognitive brain responses in humans. However rodent fMRI has not previously been applied to the analysis of learned behaviour in awake animals, limiting its

Externí odkaz: https://doaj.org/article/b30e294a49534872a55dd1317e784fbb

Female HPA axis displays heightened sensitivity to pre-pubertal stress

Autor: Nichola M. Brydges, Caroline Best, Kerrie L. Thomas

Early life stress (ELS) is a risk factor in the development of psychiatric disorders. The underlying biological mechanisms governing this phenomenon are not fully understood, but dysregulation of stress responses is likely to play a key role. Males a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967587b0a99e8feec5c19783805e131a