Zobrazeno 1 - 10
of 1 198
pro vyhledávání: '"M. Brunger"'
Autor:
Megan L. Libke, Daniel J. Cunningham, Bridgette D. Furman, John S. Yi, Jonathan M. Brunger, Virginia B. Kraus, Farshid Guilak, Amy L. McNulty, Steven A. Olson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Although various joint injuries result in post-traumatic osteoarthritis (PTOA), differences in chondrocyte response to specific injuries, such as blunt compression or fracture, are unclear. Furthermore, the role of underlying joint inflammat
Externí odkaz:
https://doaj.org/article/032f9d701d224ecab5bbd0cf5939dc05
Autor:
Andrew Kjar, Mia R. Haschert, José C. Zepeda, A. Joey Simmons, Alexis Yates, Daniel Chavarria, Melanie Fernandez, Gabriella Robertson, Adam M. Abdulrahman, Hyosung Kim, Nicole T. Marguerite, Rachel K. Moen, Lauren E. Drake, Corinne W. Curry, Brian J. O’Grady, Vivian Gama, Ken S. Lau, Brad Grueter, Jonathan M. Brunger, Ethan S. Lippmann
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114874- (2024)
Summary: Human neural organoid models have become an important tool for studying neurobiology. However, improving the representativeness of neural cell populations in such organoids remains a major effort. In this work, we compared Matrigel, a commer
Externí odkaz:
https://doaj.org/article/bad739db9cd140a9bad2592c28d9945f
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Uncovering the stimulus-response histories that give rise to cell fates and behaviors is an area of great interest in developmental biology, tissue engineering, and regenerative medicine. A comprehensive accounting of cell experiences that lead to th
Externí odkaz:
https://doaj.org/article/d386869d87754255a26a0ef4c0ff4fb0
Autor:
Hyosung Kim, Kun Leng, Jinhee Park, Alexander G. Sorets, Suil Kim, Alena Shostak, Rebecca J. Embalabala, Kate Mlouk, Ketaki A. Katdare, Indigo V. L. Rose, Sarah M. Sturgeon, Emma H. Neal, Yan Ao, Shinong Wang, Michael V. Sofroniew, Jonathan M. Brunger, Douglas G. McMahon, Matthew S. Schrag, Martin Kampmann, Ethan S. Lippmann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Inflammation of brain endothelial cells is seen in neurodegenerative conditions and in aging. Here the authors examine the role of astrocytes in blood brain barrier function using an iPSC-derived cell co-culture model.
Externí odkaz:
https://doaj.org/article/106dfd6155e1471aa3dfbd079fe49bd4
Autor:
Yajuan Shi, Hyosung Kim, Catherine A. Hamann, Elizabeth M. Rhea, Jonathan M. Brunger, Ethan S. Lippmann
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-14 (2022)
Abstract Background The hormone leptin exerts its function in the brain to reduce food intake and increase energy expenditure to prevent obesity. However, most obese subjects reflect the resistance to leptin even with elevated serum leptin. Consideri
Externí odkaz:
https://doaj.org/article/a535bb02a28d4961be69eb3aff4992b3
Autor:
Nguyen PT Huynh, Catherine C Gloss, Jeremiah Lorentz, Ruhang Tang, Jonathan M Brunger, Audrey McAlinden, Bo Zhang, Farshid Guilak
Publikováno v:
eLife, Vol 9 (2020)
The roles of long noncoding RNAs (lncRNAs) in musculoskeletal development, disease, and regeneration remain poorly understood. Here, we identified the novel lncRNA GRASLND (originally named RNF144A-AS1) as a regulator of mesenchymal stem cell (MSC) c
Externí odkaz:
https://doaj.org/article/a5af8116dd18438a86a17668158b0f61
Publikováno v:
Stem Cell Reports, Vol 8, Iss 5, Pp 1202-1213 (2017)
Chronic inflammatory diseases such as arthritis are characterized by dysregulated responses to pro-inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor α (TNF-α). Pharmacologic anti-cytokine therapies are often effective at
Externí odkaz:
https://doaj.org/article/3c34272b39464b89b769fe08f5f94276
Autor:
Joanne C. Lee, Hannah J. Brien, Bonnie L. Walton, Zachary M. Eidman, Satoshi Toda, Wendell A. Lim, Jonathan M. Brunger
Publikováno v:
Biomaterials. 297:122099
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cee78a1add527732184558dc14380d95
https://doi.org/10.1016/j.biomaterials.2023.122099
https://doi.org/10.1016/j.biomaterials.2023.122099
Publikováno v:
Current Opinion in Biomedical Engineering. 16:42-51
Cell therapies represent a vital pillar of the regenerative medicine approach to treating diseases. Unlike small molecules or biologic drugs, cells can integrate information from their environment to perform an array of outputs as diverse as the asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::498ea926fb09fbdb7886690e68749a3f
https://doi.org/10.1016/j.cobme.2020.100252
https://doi.org/10.1016/j.cobme.2020.100252
Autor:
Luke E. Springer, Natalia S. Harasymowicz, Alison K. Ross, Chia-Lung Wu, Lara Pferdehirt, Jonathan M. Brunger, Kelsey H. Collins, Franklin T. Moutos, Farshid Guilak, Yun-Rak Choi, Christine T.N. Pham
Publikováno v:
Science advances. 7(36)
Biologic drug therapies are increasingly used for inflammatory diseases such as rheumatoid arthritis but may cause significant adverse effects when delivered continuously at high doses. We used CRISPR-Cas9 genome editing of iPSCs to create a syntheti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa7243e8dea3967ae714eb5d40192c1
https://pubmed.ncbi.nlm.nih.gov/34588661
https://pubmed.ncbi.nlm.nih.gov/34588661