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Contrasting mechanisms of action and sensitivity to antipsychotics of phencyclidine versus amphetamine: importance of nucleus accumbens 5-HT2Asites for PCP-induced locomotion in the rat

Autor: M. Brocco, J. ‐M. Rivet, Valérie Audinot, M.J. Millan, Alain Gobert, F. Joly, Adrian Newman-Tancredi, S. Maurel, K Bervoets

Publikováno v: European Journal of Neuroscience. 11:4419-4432

In the present study, the comparative mechanisms of action of phencyclidine (PCP) and amphetamine were addressed employing the parameter of locomotion in rats. PCP-induced locomotion (PLOC) was potently blocked by the selective serotonin (5-HT)2A vs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cda19d5108d5a1c8bcd430f60722fa7d
https://doi.org/10.1046/j.1460-9568.1999.00858.x

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S33005, a novel ligand at both serotonin and norepinephrine transporters: II. Behavioral profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine

Autor: M J, Millan, A, Dekeyne, M, Papp, C D, La Rochelle, C, MacSweeny, J L, Peglion, M, Brocco

Publikováno v: The Journal of pharmacology and experimental therapeutics. 298(2)

Reflecting its potent inhibition of serotonin (5-HT) reuptake (accompanying paper), S33005 blocked spontaneous tail-flicks induced by parachloroamphetamine in rats. This action was mimicked by the 5-HT reuptake inhibitor, citalopram, and the 5-HT/nor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c14b7318df192019c5eafea9b012560c
https://pubmed.ncbi.nlm.nih.gov/11454919

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S18616, a highly potent spiroimidazoline agonist at alpha(2)-adrenoceptors: II. Influence on monoaminergic transmission, motor function, and anxiety in comparison with dexmedetomidine and clonidine

Autor: M J, Millan, F, Lejeune, A, Gobert, M, Brocco, A, Auclair, C, Bosc, J M, Rivet, J M, Lacoste, A, Cordi, A, Dekeyne

Publikováno v: The Journal of pharmacology and experimental therapeutics. 295(3)

The alpha(2)-adrenoceptor (AR) agonist, S18616 ((S)-spiro[(1-oxa-2-amino-3-azacyclopent-2-ene)-4,2'-(8'-chloro-1' , 2',3',4'-tetrahydronaphthalene)] accompanying article), suppressed electrical activity of adrenergic neurons in the locus ceruleus, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2c493d9a729c05369c75ee333b9ee12
https://pubmed.ncbi.nlm.nih.gov/11082458

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S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors: II. Functional and behavioral profile compared with GR218,231 and L741,626

Autor: M J, Millan, A, Dekeyne, J M, Rivet, T, Dubuffet, G, Lavielle, M, Brocco

Publikováno v: The Journal of pharmacology and experimental therapeutics. 293(3)

The selective dopamine D(3)-receptor antagonist S33084 dose dependently attenuated induction of hypothermia by 7-hydroxy-2-dipropylaminotetralin (7-OH-DPAT) and PD128,907. S33084 also dose dependently reduced 7-OH-DPAT-induced penile erections (PEs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2e672a03ae8695ee936600995060632a
https://pubmed.ncbi.nlm.nih.gov/10869411

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Induction of spontaneous tail-flicks in rats by blockade of transmission at N-methyl-D-aspartate receptors: roles of multiple monoaminergic receptors in relation to the actions of antipsychotic agents

Autor: M J, Millan, A, Gobert, K, Bervoets, J M, Rivet, S, Veiga, M, Brocco

Publikováno v: The Journal of pharmacology and experimental therapeutics. 292(2)

We examined the involvement of multiple monoaminergic receptors in the induction of spontaneous tail-flicks (STFs) by the open channel blocker at N-methyl-D-aspartate (NMDA) receptors, dizocilpine, and the NMDA recognition site antagonist 3-(2-carbox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a4ff3362b3d8c23e281988ecce8673b7
https://pubmed.ncbi.nlm.nih.gov/10640305

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S18327 (1-[2-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)piperid-1-yl]ethyl]3-phenyl imidazolin-2-one), a novel, potential antipsychotic displaying marked antagonist properties at alpha(1)- and alpha(2)-adrenergic receptors: II. Functional profile and a multiparametric comparison with haloperidol, clozapine, and 11 other antipsychotic agents

Autor: M J, Millan, M, Brocco, J M, Rivet, V, Audinot, A, Newman-Tancredi, L, Maiofiss, S, Queriaux, N, Despaux, J L, Peglion, A, Dekeyne

Publikováno v: The Journal of pharmacology and experimental therapeutics. 292(1)

S18327 was dose-dependently active in several models of potential antipsychotic activity involving dopaminergic hyperactivity: inhibition of apomorphine-induced climbing in mice, of cocaine- and amphetamine-induced hyperlocomotion in rats, and of con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7463c54bbf7a554a5a976e33438c97e9
https://pubmed.ncbi.nlm.nih.gov/10604931

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Contrasting mechanisms of action and sensitivity to antipsychotics of phencyclidine versus amphetamine: importance of nucleus accumbens 5-HT2A sites for PCP-induced locomotion in the rat

Autor: M J, Millan, M, Brocco, A, Gobert, F, Joly, K, Bervoets, J, Rivet, A, Newman-Tancredi, V, Audinot, S, Maurel

Publikováno v: The European journal of neuroscience. 11(12)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a5157100328f40daea058df9b813c310
https://pubmed.ncbi.nlm.nih.gov/10594669

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S-16924 [(R)-2-[1-[2-(2,3-dihydro-benzo[1,4]dioxin-5-yloxy)-ethyl]- pyrrolidin-3yl]-1-(4-fluorophenyl)-ethanone], a novel, potential antipsychotic with marked serotonin1A agonist properties: III. Anxiolytic actions in comparison with clozapine and haloperidol

Autor: M J, Millan, M, Brocco, A, Gobert, R, Schreiber, A, Dekeyne

Publikováno v: The Journal of pharmacology and experimental therapeutics. 288(3)

S-16924 is a potential antipsychotic that displays agonist and antagonist properties at serotonin (5-HT)1A and 5-HT2A/2C receptors, respectively. In a pigeon conflict procedure, the benzodiazepine clorazepate (CLZ) increased punished responses, an ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ed124b3dde0373647a66a69ae5a8f01
https://pubmed.ncbi.nlm.nih.gov/10027837

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A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194

Autor: V, Audinot, A, Newman-Tancredi, A, Gobert, J M, Rivet, M, Brocco, F, Lejeune, L, Gluck, I, Desposte, K, Bervoets, A, Dekeyne, M J, Millan

Publikováno v: The Journal of pharmacology and experimental therapeutics. 287(1)

The benzofurane (+)-S 14297, the benzamide nafadotride, the aminoindane U 99194 and the arylpiperazine GR 103,691 have been proposed as "selective" antagonists at dopamine D3 vs. D2 receptors. Herein, we compared their in vitro affinities and in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b20b9fcaabda68cea4099ccfdd016f4c
https://pubmed.ncbi.nlm.nih.gov/9765337

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