Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infectionResearch in context

Autor: Lihui Guo, Brent Appelman, Kirsten Mooij-Kalverda, Riekelt H. Houtkooper, Michel van Weeghel, Frédéric M. Vaz, Annemiek Dijkhuis, Tamara Dekker, Barbara S. Smids, Jan Willem Duitman, Marianna Bugiani, Paul Brinkman, Jonne J. Sikkens, H.A. Ayesha Lavell, Rob C.I. Wüst, Michèle van Vugt, René Lutter, M.A. van Agtmael, A.G. Algera, B. Appelman, F.E.H.P. van Baarle, M. Beudel, H.J. Bogaard, M. Bomers, P.I. Bonta, L.D.J. Bos, M. Botta, J. de Brabander, G.J. de Bree, S. de Bruin, M. Bugiani, E.B. Bulle, O. Chouchane, A.P.M. Cloherty, D. Buis, M.C.F.J. de Rotte, M. Dijkstra, D.A. Dongelmans, R.W.G. Dujardin, P.E. Elbers, L.M. Fleuren, S.E. Geerlings, T.B.H. Geijtenbeek, A.R.J. Girbes, A. Goorhuis, M.P. Grobusch, L.A. Hagens, J. Hamann, V.C. Harris, R. Hemke, S.M. Hermans, L.M.A. Heunks, M.W. Hollmann, J. Horn, J.W. Hovius, M.D. de Jong, R. Koing, E.H.T. Lim, N. van Mourik, J.F. Nellen, E.J. Nossent, F. Paulus, E. Peters, D. Piña-Fuentes, T. van der Poll, B. Preckel, J.M. Prins, S.J. Raasveld, T.D.Y. Reijnders, M. Schinkel, F.A.P. Schrauwen, M.J. Schultz, A.R. Schuurman, J. Schuurmans, K. Sigaloff, M.A. Slim, P. Smeele, M.R. Smit, C. Stijnis, W. Stilma, C.E. Teunissen, P. Thoral, A.M. Tsonas, P.R. Tuinman, M. van der Valk, D.P. Veelo, C. Volleman, H. de Vries, L.A. van Vught, M. van Vugt, D. Wouters, A.H. Zwinderman, M.C. Brouwer, W.J. Wiersinga, A.P.J. Vlaar, D. van de Beek

Publikováno v: EBioMedicine, Vol 94, Iss , Pp 104729- (2023)

Summary: Background: Post-acute sequela of SARS-CoV-2 infection (PASC) encompass fatigue, post-exertional malaise and cognitive problems. The abundant expression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase-2 (IDO2) in fatal/seve

Externí odkaz: https://doaj.org/article/d01232b4f65044ae908001bceb0907e4

Revisiting paramagnetic relaxation enhancements in slowly rotating systems: how long is the long range?

Autor: G. Bellomo, E. Ravera, V. Calderone, M. Botta, M. Fragai, G. Parigi, C. Luchinat

Publikováno v: Magnetic Resonance, Vol 2, Pp 25-31 (2021)

Cross-relaxation terms in paramagnetic systems that reorient rigidly with slow tumbling times can increase the effective longitudinal relaxation rates of protons of more than 1 order of magnitude. This is evaluated by simulating the time evolution of

Externí odkaz: https://doaj.org/article/d5344708507d43e498bc51449742d509

Identification, synthesis and biological activity of alkyl-guanidine oligomers as potent antibacterial agents

Autor: C. Zamperini, G. Maccari, D. Deodato, C. Pasero, I. D’Agostino, F. Orofino, F. De Luca, E. Dreassi, J. D. Docquier, M. Botta

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Abstract In the last two decades, the repertoire of clinically effective antibacterials is shrinking due to the rapidly increasing of multi-drug-resistant pathogenic bacteria. New chemical classes with innovative mode of action are required to preven

Externí odkaz: https://doaj.org/article/1bb4259c9b7640c9a32a6b86733d74b8

Entanglement from Dissipation and Holographic Interpretation

Autor: Cantcheff, M. Botta, Gadelha, Alexandre L., Marchioro, Dáfni F. Z., Nedel, Daniel Luiz

Publikováno v: Eur. Phys. J. C78 (2018) no.2, 105

In this work we study a dissipative field theory where the dissipation process is manifestly related to dynamical entanglement and put it in the holographic context. Such endeavour is realized by further development of a canonical approach to study q

Externí odkaz: http://arxiv.org/abs/1702.02069

TFD Extension of Open String Field Theory

Autor: Cantcheff, M. Botta, Santos, R. J. Scherer

Publikováno v: Phys. Rev. D 93, 065015 (2016)

We study the application of the rules of Thermo Field Dynamics (TFD) to the covariant formulation of Open String Field Theory (OSFT). We extend the states space and fields according to the duplication rules of TFD and construct the corresponding clas

Externí odkaz: http://arxiv.org/abs/1508.03603