Zobrazeno 1 - 10
of 332
pro vyhledávání: '"M. Binoux"'
Publikováno v:
Journal of Endocrinology. 152:221-227
The IGF system is involved in the growth and differentiation of neuroblastoma cells, but the precise roles played by the IGF-binding proteins (IGFBPs) remain unknown. We have examined the expression and functions of IGFBPs produced by the neuroblasto
Publikováno v:
Hormone Research. 45:156-159
Limited proteolysis of insulin-like growth factor-binding protein-3 (IGFBP-3) is a normal process in the regulation of insulin-like growth factor (IGF) activity, which we have reproduced in vitro using plasmin and recombinant human non-glycosylated I
Publikováno v:
The Journal of clinical endocrinology and metabolism. 86(5)
The ligand immunofunctional assay for plasma insulin-like growth factor (IGF) binding protein (IGFBP)-3 developed in our laboratory provides for specific measurement of intact, as opposed to proteolyzed, IGFBP-3. IGFBP-bound IGFs are dissociated and
Autor:
C, Lassarre, M, Binoux
Publikováno v:
The Journal of clinical endocrinology and metabolism. 86(3)
Limited proteolysis of insulin-like growth factor binding protein-3 (IGFBP-3) is a fundamental mechanism in the regulation of IGF-I bioavailability in the bloodstream. Its measurement by Western immunoblotting provides only semiquantitative estimatio
Autor:
J M, Ricort, M, Binoux
Publikováno v:
Endocrinology. 142(1)
Insulin-like growth factor binding proteins (IGFBPs) regulate the cellular actions of the IGFs owing to their strong affinities, which are equal to or stronger than the affinity of the type 1 IGF receptor (IGF-IR), the mediator of IGF signal transduc
Autor:
M. Binoux, S. Mohan, Ron G. Rosenfeld, S. L.S. Drop, D. R. Clemmons, J. M.P. Holly, C. A. Conover, Youngman Oh, Robert C. Baxter
Publikováno v:
Growth hormoneIGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. 8(3)
Publikováno v:
Endocrinology. 140(9)
The regulation of insulin-like growth factor binding protein (IGFBP)-4 proteolytic degradation by insulin-like growth factors (IGFs) has been largely studied in vitro, but not in vivo. The aim of this study was to investigate the involvement of IGFs,
Publikováno v:
Endocrinology. 138(7)
Study of the in vivo functions of the insulin-like growth factor binding proteins (IGFBPs) is complicated by their variety (six molecular species) and the differences in their expression related to tissue of origin and stage of development. To invest
Publikováno v:
Growth regulation. 6(3)
Insulin-like growth factor-binding proteins (IGFBPs) modulate IGF action at cellular level, through either inhibition or potentiation, and they also have intrinsic activity that is independent of their binding to IGFs. In prostate carcinoma (PC-3) ce
Publikováno v:
Growth regulation. 6(3)
Measurements of serum levels of insulin-like growth factor (IGF)-I, IGF-II and IGF binding protein (IGFBP)-1 have been carried out in conjunction with Western ligand blot analysis of serum IGFBPs in 39 constitutionally short children and adolescents