Zobrazeno 1 - 10
of 126
pro vyhledávání: '"M. Bignell"'
Autor:
Margherita Bertuzzi, Gareth J. Howell, Darren D. Thomson, Rachael Fortune-Grant, Anna Möslinger, Patrick Dancer, Norman Van Rhijn, Natasha Motsi, Alice Codling, Elaine M. Bignell
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109939- (2024)
Summary: Hundreds of spores of Aspergillus fumigatus (Af) are inhaled daily by human beings, representing a constant, possibly fatal, threat to respiratory health. The small size of Af spores suggests that interactions with alveolar epithelial cells
Externí odkaz:
https://doaj.org/article/ff7b9b1ee6e3455b85a6661245bccc68
Publikováno v:
mSphere, Vol 7, Iss 1 (2022)
ABSTRACT Previously, 1,8-dihydroxynaphthalene (DHN)-melanin was described to protect Aspergillus fumigatus against hydrogen peroxide (H2O2), thereby protecting this opportunistic human pathogen from reactive oxygen species generated by the immune sys
Externí odkaz:
https://doaj.org/article/35f5ed314083425bb9f14dc3a669f36f
Autor:
Larissa L.H. John, Darren D. Thomson, Tihana Bicanic, Martin Hoenigl, Alistair J.P. Brown, Thomas S. Harrison, Elaine M. Bignell
Candida aurisis an emerging, multi-drug resistant fungal pathogen that causes refractory colonisation and life-threatening invasive nosocomial infections. The high proportion ofC. aurisisolates that display antifungal resistance severely limits treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f87c74a6ce87646f0b534900b4e7ef3
https://doi.org/10.1101/2022.12.16.520848
https://doi.org/10.1101/2022.12.16.520848
Autor:
Margherita Bertuzzi, Gemma E. Hayes, Uju J. Icheoku, Norman van Rhijn, David W. Denning, Nir Osherov, Elaine M. Bignell
Publikováno v:
Journal of Fungi, Vol 4, Iss 1, p 8 (2018)
Respiratory epithelia fulfil multiple roles beyond that of gaseous exchange, also acting as primary custodians of lung sterility and inflammatory homeostasis. Inhaled fungal spores pose a continual antigenic, and potentially pathogenic, challenge to
Externí odkaz:
https://doaj.org/article/380e5a2b297b453197a97f00366d3ad1
Autor:
Margherita Bertuzzi, Markus Schrettl, Laura Alcazar-Fuoli, Timothy C Cairns, Alberto Muñoz, Louise A Walker, Susanne Herbst, Maryam Safari, Angela M Cheverton, Dan Chen, Hong Liu, Shinobu Saijo, Natalie D Fedorova, Darius Armstrong-James, Carol A Munro, Nick D Read, Scott G Filler, Eduardo A Espeso, William C Nierman, Hubertus Haas, Elaine M Bignell
Publikováno v:
PLoS Pathogens, Vol 11, Iss 6, p e1004943 (2015)
Externí odkaz:
https://doaj.org/article/c880268257a74b16a9be6c171f0b5a5e
Autor:
Alberto Muñoz, Margherita Bertuzzi, Jan Bettgenhaeuser, Nino Iakobachvili, Elaine M Bignell, Nick D Read
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138008 (2015)
Aspergillus fumigatus is an inhaled fungal pathogen of human lungs, the developmental growth of which is reliant upon Ca2+-mediated signalling. Ca2+ signalling has regulatory significance in all eukaryotic cells but how A. fumigatus uses intracellula
Externí odkaz:
https://doaj.org/article/37ec36f4749d4bd7ba99833af3a7e07c
Autor:
Margherita Bertuzzi, Markus Schrettl, Laura Alcazar-Fuoli, Timothy C Cairns, Alberto Muñoz, Louise A Walker, Susanne Herbst, Maryam Safari, Angela M Cheverton, Dan Chen, Hong Liu, Shinobu Saijo, Natalie D Fedorova, Darius Armstrong-James, Carol A Munro, Nick D Read, Scott G Filler, Eduardo A Espeso, William C Nierman, Hubertus Haas, Elaine M Bignell
Publikováno v:
PLoS Pathogens, Vol 10, Iss 10, p e1004413 (2014)
Destruction of the pulmonary epithelium is a major feature of lung diseases caused by the mould pathogen Aspergillus fumigatus. Although it is widely postulated that tissue invasion is governed by fungal proteases, A. fumigatus mutants lacking indivi
Externí odkaz:
https://doaj.org/article/eb8eb45ee83a4e99a63533f7c78440cd
Publikováno v:
Frontiers in Microbiology, Vol 4 (2013)
Aspergillus fumigatus is the most pathogenic species among the Aspergilli, and the major fungal agent of human pulmonary infection. To prosper in diverse ecological niches, Aspergilli have evolved numerous mechanisms for adaptive gene regulation, som
Externí odkaz:
https://doaj.org/article/d01376f3deab4f1a8f4edc1ccaf56047
Autor:
Daniel A Henk, Revital Shahar-Golan, Khuraijam Ranjana Devi, Kylie J Boyce, Nengyong Zhan, Natalie D Fedorova, William C Nierman, Po-Ren Hsueh, Kwok-Yung Yuen, Tran P M Sieu, Nguyen Van Kinh, Heiman Wertheim, Stephen G Baker, Jeremy N Day, Nongnuch Vanittanakom, Elaine M Bignell, Alex Andrianopoulos, Matthew C Fisher
Publikováno v:
PLoS Pathogens, Vol 8, Iss 10, p e1002851 (2012)
Molecular genetic approaches typically detect recombination in microbes regardless of assumed asexuality. However, genetic data have shown the AIDS-associated pathogen Penicillium marneffei to have extensive spatial genetic structure at local and reg
Externí odkaz:
https://doaj.org/article/bf0903e2533c4b0db3b7da4c231e1509
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