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Pharmacokinetics and pharmacodynamics of imatinib for optimal drug repurposing from cancer to COVID-19

Autor: Nadia Baalbaki, Erik Duijvelaar, Medhat M. Said, Job Schippers, Pierre M. Bet, Jos Twisk, Sarah Fritchley, Cristina Longo, Kazien Mahmoud, Anke H. Maitland-van der Zee, Harm Jan Bogaard, Eleonora L. Swart, Jurjan Aman, Imke H. Bartelink

Publikováno v: Baalbaki, N, Duijvelaar, E, Said, M M, Schippers, J, Bet, P M, Twisk, J, Fritchley, S, Longo, C, Mahmoud, K, Maitland-van der Zee, A H, Bogaard, H J, Swart, E L, Aman, J & Bartelink, I H 2023, ' Pharmacokinetics and pharmacodynamics of imatinib for optimal drug repurposing from cancer to COVID-19 ', European Journal of Pharmaceutical Sciences, vol. 184, 106418 . https://doi.org/10.1016/j.ejps.2023.106418
European Journal of Pharmaceutical Sciences, 184:106418. Elsevier

Introduction: In the randomized double-blind placebo-controlled CounterCOVID study, oral imatinib treatment conferred a positive clinical outcome and a signal for reduced mortality in COVID-19 patients. High concentrations of alpha-1 acid glycoprotei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ca77a4480a98326896ab48f4b0e96e
https://research.vumc.nl/en/publications/269bef74-d9b2-46e0-b8b4-50fa6d0d2bc8

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Implementation of a pharmacist-led transitional pharmaceutical care programme

Autor: Selma En‐nasery‐de Heer, Elien B. Uitvlugt, Pierre M. Bet, Bart J. F. van den Bemt, Aida Alai, Patricia M. L. A. van den Bemt, Eleonora L. Swart, Fatma Karapinar‐Çarkit, Jacqueline G. Hugtenburg

Publikováno v: Journal of Clinical Pharmacy and Therapeutics, 47, 7, pp. 1049-1069
Journal of Clinical Pharmacy and Therapeutics, 47(7), 1049-1069. Blackwell Publishing Ltd
en-nasery-de Heer, S, Uitvlugt, E B, Bet, P M, van den Bemt, B J F, Alai, A, van den Bemt, P M L A, Swart, E L, Karapinar-Çarkit, F & Hugtenburg, J G 2022, ' Implementation of a pharmacist-led transitional pharmaceutical care programme : Process evaluation of Medication Actions to Reduce hospital admissions through a collaboration between Community and Hospital pharmacists (MARCH) ', Journal of Clinical Pharmacy and Therapeutics, vol. 47, no. 7, pp. 1049-1069 . https://doi.org/10.1111/jcpt.13645
Journal of Clinical Pharmacy and Therapeutics, 47(7), 1049-1069. Wiley-Blackwell
Journal of Clinical Pharmacy and Therapeutics, 47, 1049-1069

Contains fulltext : 283012.pdf (Publisher’s version ) (Open Access) WHAT IS KNOWN AND OBJECTIVE: The recently conducted Medication Actions to Reduce hospital admissions through a collaboration between Community and Hospital pharmacists (MARCH) tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b930d2521d2150f6c7d2a737e8018592
https://doi.org/10.1111/jcpt.13645

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Evaluation of marketing authorization and clinical implementation of ulipristal acetate for uterine fibroids

Autor: Mei-An Middelkoop, Maria E de Lange, T Justin Clark, Ben Willem J Mol, Pierre M Bet, Judith A F Huirne, Wouter J K Hehenkamp

Publikováno v: Middelkoop, M-A, de Lange, M E, Clark, T J, Mol, B W J, Bet, P M, Huirne, J A F & Hehenkamp, W J K 2022, ' Evaluation of marketing authorization and clinical implementation of ulipristal acetate for uterine fibroids ', Human reproduction (Oxford, England), vol. 37, no. 5, pp. 884-894 . https://doi.org/10.1093/humrep/deac009

Ulipristal acetate (UPA) is a medical treatment for uterine fibroids and was authorized for surgical pre-treatment in 2012 after the conduct of the PEARL I and II randomized controlled trials and for intermittent treatment after the observational PEA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d305f460dbe110f370fa6ff6f7b66a7
https://doi.org/10.1093/humrep/deac009

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The effect of a transitional pharmaceutical care program on the occurrence of ADEs after discharge from hospital in patients with polypharmacy

Autor: Selma En-nasery-de Heer, Jacqueline G. Hugtenburg, Pierre M. Bet, Bart J F van den Bemt, Patricia M. L. A. van den Bemt, Elien B. Uitvlugt, Ferdi Sombogaard, Fatma Karapinar-Çarkit

Publikováno v: Research in Social and Administrative Pharmacy, 18(4), 2651-2658. ELSEVIER SCIENCE INC
Uitvlugt, E B, Heer, S E-N, van den Bemt, B J F, Bet, P M, Sombogaard, F, Hugtenburg, J G, van den Bemt, P M L A & Karapinar-Çarkit, F 2021, ' The effect of a transitional pharmaceutical care program on the occurrence of ADEs after discharge from hospital in patients with polypharmacy ', Research in Social and Administrative Pharmacy . https://doi.org/10.1016/j.sapharm.2021.05.009
Research in Social and Administrative Pharmacy. Elsevier Inc.
Research in Social & Administrative Pharmacy, 18, 2651-2658
Research in Social & Administrative Pharmacy, 18, 4, pp. 2651-2658
Research in Social and Administrative Pharmacy, 18(4), 2651-2658. Elsevier Inc.

Introduction: Transitional care programs (i.e. interventions delivered both in hospital and in primary care), could increase continuity and consequently quality of care. However, limited studies on the effect of these programs on Adverse Drug Events

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec2e470f0f3ed30ceddf213b6d3c7bc2
https://pure.eur.nl/en/publications/5c23ad9e-f2ab-47e8-a837-b2ed502da97b

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Elevated acute phase proteins affect pharmacokinetics in COVID-19 trials

Autor: Ivo P E Tielbeek, Richard Honeywell, Bram Grob, Pierre M Bet, Harm Jan Bogaard, Monia Guidi, Erik Duijvelaar, Imke H Bartelink, Eleonora L Swart, Nicolas Widmer, Laurent A. Decosterd, Jurjan Aman, Amanda Evelo, Sue D Snape, Henrike Hamer

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology
CPT, vol. 10, no. 12, pp. 1497-1511
Bartelink, I H, Bet, P M, Widmer, N, Guidi, M, Duijvelaar, E, Grob, B, Honeywell, R, Evelo, A, Tielbeek, I P E, Snape, S D, Hamer, H, Decosterd, L A, Bogaard, H J, Aman, J & Swart, E L 2021, ' Elevated acute phase proteins affect pharmacokinetics in COVID-19 trials : lessons from the CounterCovid-imatinib-study ', CPT: Pharmacometrics and Systems Pharmacology, vol. 10, no. 12, pp. 1497-1511 . https://doi.org/10.1002/psp4.12718
CPT: Pharmacometrics and Systems Pharmacology, 10(12), 1497-1511. Wiley-Blackwell
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 12, Pp 1497-1511 (2021)

This study aimed to determine whether published pharmacokinetic (PK) models can adequately predict the PK profile of imatinib in a new indication, such as coronavirus disease 2019 (COVID-19). Total (bound + unbound) and unbound imatinib plasma concen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b0113a10ff46f52c554a392c3057f2
https://doi.org/10.1002/psp4.12718

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A new approach to drug intravenous compatibility research: The case of obstetric parenteral drugs

Autor: A F Leeuwerik, L N van Merendonk, M A de Boer, A J Wilhelm, A Kolkman, P M Bet

Publikováno v: European Journal of Hospital Pharmacy. European Association of Hospital Pharmacists (EAHP)
Leeuwerik, A F, van Merendonk, L N, de Boer, M A, Wilhelm, A J, Kolkman, A & Bet, P M 2023, ' A new approach to drug intravenous compatibility research : The case of obstetric parenteral drugs ', European Journal of Hospital Pharmacy . https://doi.org/10.1136/ejhpharm-2022-003577

Objectives: The product information and literature does not provide confirmation of compatibility for co-administration of all commonly used drug pairs in obstetrics. However, there is a need for co-administration of these drugs over one lumen for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5600783a585c7f3022de59bfdb4f2133
https://research.vumc.nl/en/publications/26e92c26-3659-4100-8491-95ab3ee8e8a5

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[Guided discontinuation of antidepressants: approach and first results of a Dutch multidisciplinary outpatient clinic]

Autor: E, Dozeman, H J, van der Lande, P M, Bet, K, Fransen, I, Jager, J, Jonker, E, Philippo, J, Reisman-Dolman, D J F, van Schaik, W, Scholten, I, van de Velde, V, Verheijen, M, van der Wart, M, van Zon, N, Batelaan, C H, Vinkers

Publikováno v: Tijdschrift voor psychiatrie. 64(9)

Discontinuation of antidepressant medication can be difficult due to withdrawal symptoms and relapse risk. Scientific evidence on the questions of who, when, and how to stop antidepressants is limited. In Amsterdam a multidisciplinary outpatient clin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4f9f96d3bfe2f6348c06cb47b9bdb415
https://pubmed.ncbi.nlm.nih.gov/36349853

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Therapeutic Drug Monitoring of Psychotropics as a Diagnostic Tool for CYP2D6 Poor Metabolizer Phenotype

Autor: Soraya V Ganesh, Pierre M. Bet, Bojan Nikolik, Lianne Beunk, Jan van der Weide

Publikováno v: Therapeutic Drug Monitoring, 43(5), 672-680. Lippincott Williams and Wilkins
Ganesh, S V, Beunk, L, Nikolik, B, van der Weide, J & Bet, P M 2021, ' Therapeutic Drug Monitoring of Psychotropics as a Diagnostic Tool for CYP2D6 Poor Metabolizer Phenotype ', Therapeutic Drug Monitoring, vol. 43, no. 5, pp. 672-680 . https://doi.org/10.1097/FTD.0000000000000868

BACKGROUND: Interpatient variability in cytochrome P450 2D6 (CYP2D6) enzyme activity alters the serum concentrations of most psychotropics, which often have narrow therapeutic indices. Therefore, preemptive knowledge of CYP2D6 activity is desired. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a6f5d353a74c7cbd1d67161f759929
https://doi.org/10.1097/ftd.0000000000000868

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