Výsledky vyhledávání

MMP10 Promotes Efficient Thrombolysis After Ischemic Stroke in Mice with Induced Diabetes

Autor: Carmen Roncal, M. Belzunce, Jose A. Rodriguez, Beatriz Zandio, Manuel Navarro-Oviedo, José A. Páramo, Estefanía Toledo, Agustina Salicio, Obdulia Rabal, Josune Orbe, Roberto Muñoz

Publikováno v: Translational Stroke Research. 10:389-401

Diabetes is an important risk factor for ischemic stroke (IS). Tissue-type plasminogen activator (tPA) has been associated with less successful revascularization and poor functional outcome in diabetes. We assessed whether a new thrombolytic strategy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc4fe1e9f9656a2bd06866aff26bf23
https://doi.org/10.1007/s12975-018-0652-9

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Matrix metalloproteinase-10 deficiency delays atherosclerosis progression and plaque calcification

Autor: William C. Parks, Ana Purroy, Vicente Andrés, Carmen Roncal, Olivier Meilhac, José A. Páramo, M. Belzunce, Jose A. Rodriguez, Josune Orbe, Ricardo Villa-Bellosta, Guillermo Zalba

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)

BACKGROUND AND AIMS: Matrix metalloproteinases (MMPs) have been implicated in atherosclerosis and vascular calcification. Among them, we reported that MMP10 is present in human atheroma, associated with atherosclerosis. However, it remains unclear wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0c52929fb1601a666d1417015a30ca
https://hdl.handle.net/20.500.12105/9666

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Design, Synthesis, and Biological Evaluation of Novel Matrix Metalloproteinase Inhibitors As Potent Antihemorrhagic Agents: From Hit Identification to an Optimized Lead

Autor: Haizhong Tan, M. Belzunce, Josune Orbe, Juan A. Sánchez-Arias, Wei Wu, Ana Ugarte, Musheng Xu, Jose A. Rodriguez, Agustina Salicio, Hongyu Ma, José A. Páramo, Obdulia Rabal, Julen Oyarzabal

Publikováno v: Journal of Medicinal Chemistry. 58:2465-2488

Growing evidence suggests that matrix metalloproteinases (MMP) are involved in thrombus dissolution; then, considering that new therapeutic strategies are required for controlling hemorrhage, we hypothesized that MMP inhibition may reduce bleeding by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92beafb59762595de1ce8494431b507f
https://doi.org/10.1021/jm501940y

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Adipose Stromal Vascular Fraction Improves Cardiac Function in Chronic Myocardial Infarction Through Differentiation and Paracrine Activity

Autor: M. Belzunce, Miriam Araña, José A. Páramo, Juana Merino, José Manuel García Verdugo, Felipe Prosper, Margarita Ecay, Mario Soriano, Beatriz Pelacho, Cristina Moreno, Manuel Mazo, Salomón Hernández, Arantxa Cemborain, Mayte Casado, Gloria Abizanda, Edurne Albiasu, Juan José Gavira, Josune Orbe, Iván Peñuelas

Publikováno v: Cell Transplantation
Cell Transplantation; Vol 21
Cell Transplantation, Vol 21 (2012)

Fresh adipose-derived cells have been shown to be effective in the treatment of acute myocardial infarction (MI), but their role in the chronic setting is unknown. We sought to determine the long-term effect of the adipose derived-stromal vascular fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d1c2284234a1115056e1e15d1544f5

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Metaloproteasa-10 (estromelisina-2): un nuevo marcador de aterosclerosis subclínica

Autor: Carmen Roncal, José A. Páramo, M. Belzunce, Oscar Beloqui, Jose A. Rodriguez, Josune Orbe

Publikováno v: Clínica e Investigación en Arteriosclerosis. 19:122-128

Objetivo Las metaloproteasas (MMP) son una familia de endopeptidasas que degradan la matriz extracelular y desempenan un papel clave en la aterogenesis. La MMP-10 (estromelisina-2) se asocia con inflamacion en sujetos asintomaticos con factores de ri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0348e8e77bbc5b5c5dd3ba8b48dcecdf
https://doi.org/10.1016/s0214-9168(07)74185-2

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Lack of TAFI increases brain damage and microparticle generation after thrombolytic therapy in ischemic stroke

Autor: P. Bibiot, J.A. Rodriguez, José A. Páramo, M. Belzunce, Joost C. M. Meijers, Nicoleta Alexandru, C. Roncal, Josune Orbe, Adriana Georgescu

Publikováno v: Thrombosis research, 136(2), 445-450. Elsevier Limited

Background: Thrombin-activatable fibrinolysis inhibitor (TAFI) plays an important role in coagulation and fibrinolysis. Whereas TAFI deficiency may lead to a haemorrhagic tendency, data from TAFI knockout mice (TAFI-/-) are controversial and no diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476bd760269c6dbee468e8d4ecd83ccc
https://pure.amc.nl/en/publications/lack-of-tafi-increases-brain-damage-and-microparticle-generation-after-thrombolytic-therapy-in-ischemic-stroke(d11d5d4f-d5cf-4a45-83d8-76e5c34774d3).html

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Antioxidant vitamins increase the collagen content and reduce MMP-1 in a porcine model of atherosclerosis: implications for plaque stabilization

Autor: C. Roncal, José A. Páramo, Beatriz Nespereira, Josune Orbe, J.A. Rodriguez, Maitane Pérez-Ilzarbe, M. Belzunce, Roberto Arias

Publikováno v: Atherosclerosis. 167:45-53

Degradation of extracellular matrix, particularly interstitial collagen, promotes plaque instability and contributes to restenosis after vascular injury. We have explored the effects of vitamins C and E on the collagen content and metalloproteinase-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1cf5fedd6f6232231e0715a7c4e6893
https://doi.org/10.1016/s0021-9150(02)00392-1

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Phagocytic NADPH oxidase-dependent superoxide production stimulates matrix metalloproteinase-9: implications for human atherosclerosis

Autor: M. Belzunce, María U. Moreno, Oscar Beloqui, Josune Orbe, Guillermo Zalba, Ana Fortuño, Jose A. Rodriguez, Javier Díez, Gorka San José, José A. Páramo

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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Objective— Data suggest that matrix metalloproteinase-9 (MMP-9) has a role in atherosclerosis. The phagocytic NADPH oxidase has been also associated with atherosclerosis. This study aimed to investigate the association between phagocytic NADPH oxid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b033e1640038937bc193a82030ba178
https://hdl.handle.net/10171/18531

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The 4G/5G PAI-1 polymorphism influences the endothelial response to IL-1 and the modulatory effect of pravastatin

Autor: José A. Páramo, Josune Orbe, J.A. Rodriguez, M. Belzunce, C. Roncal

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
instname

BACKGROUND: Increased plasminogen activator inhibitor (PAI-1) levels lead to impaired fibrinolytic function associated with higher cardiovascular risk. PAI-1 expression may be regulated by different inflammatory cytokines such as interleukin-1alpha (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0726e4997070d6d2966f88204a4dec
https://pubmed.ncbi.nlm.nih.gov/16879223

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Protective effect of the G-765C COX-2 polymorphism on subclinical atherosclerosis and inflammatory markers in asymptomatic subjects with cardiovascular risk factors

Autor: M. Belzunce, Oscar Beloqui, Jose A. Rodriguez, C. Roncal, José A. Páramo, Josune Orbe

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
instname

BACKGROUND: Cyclooxygenase (COX)-2, a key regulatory enzyme in prostanoid synthesis, plays an important role in inflammatory processes. The -765G>C COX-2 polymorphism has been associated with lower promoter activity in vitro and reduced levels of C-r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9919a2ae9f668bfbd18cbf6ad44b22
https://hdl.handle.net/10171/22263

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