Zobrazeno 1 - 10
of 51
pro vyhledávání: '"M. Belardinelli"'
Autor:
Shiva Kumar Angala, Ana Carreras-Gonzalez, Emilie Huc-Claustre, Itxaso Anso, Devinder Kaur, Victoria Jones, Zuzana Palčeková, Juan M. Belardinelli, Célia de Sousa-d’Auria, Libin Shi, Nawel Slama, Christine Houssin, Annaïk Quémard, Michael McNeil, Marcelo E. Guerin, Mary Jackson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract We report on the existence of two phosphatidic acid biosynthetic pathways in mycobacteria, a classical one wherein the acylation of the sn-1 position of glycerol-3-phosphate (G3P) precedes that of sn-2 and another wherein acylations proceed
Externí odkaz:
https://doaj.org/article/e654bf1aa0a4424ea44490ddc8479d50
Autor:
Juan M. Belardinelli, Divya Arora, Charlotte Avanzi, William H. Wheat, Josephine M. Bryant, John S. Spencer, Tom L. Blundell, Julian Parkhill, R. Andres Floto, Mary Jackson
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Functional genomics analysis of Mycobacterium abscessus clinical isolates from chronically infected patients to identify genes under strong evolutionary pressure during lung adaptation identified phoR as one of the most frequently mutated. p
Externí odkaz:
https://doaj.org/article/2bf422acc9ed4da6817771c9620be1e0
Autor:
Juan M. Belardinelli, Wei Li, Charlotte Avanzi, Shiva K. Angala, Elena Lian, Crystal J. Wiersma, Zuzana Palčeková, Kevin H. Martin, Bhanupriya Angala, Vinicius C. N. de Moura, Callan Kerns, Victoria Jones, Mercedes Gonzalez-Juarrero, Rebecca M. Davidson, Jerry A. Nick, Bradley R. Borlee, Mary Jackson
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Characterizing Mycobacterium abscessus complex (MABSC) biofilms under host-relevant conditions is essential to the design of informed therapeutic strategies targeted to this persistent, drug-tolerant, population of extracellular bacilli. Using synthe
Externí odkaz:
https://doaj.org/article/0d74ddfc88ec4837b85ab2f3e657620d
Autor:
Vinicius C. N. de Moura, Deepshikha Verma, Isobel Everall, Karen P. Brown, Juan M. Belardinelli, Crystal Shanley, Megan Stapleton, Julian Parkhill, R. Andres Floto, Diane J. Ordway, Mary Jackson
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Chronic pulmonary infections caused by non-tuberculous mycobacteria of the Mycobacterium abscessus complex (MABSC) are emerging as a global health problem and pose a threat to susceptible individuals with structural lung disease such as cystic fibros
Externí odkaz:
https://doaj.org/article/4c82328718ca4ed19fb60efd80305910
Autor:
Sitthivut Charoensutthivarakul, Sherine E. Thomas, Amy Curran, Karen P. Brown, Juan M. Belardinelli, Andrew J. Whitehouse, Marta Acebrón-García-de-Eulate, Jaspar Sangan, Subramanian G. Gramani, Mary Jackson, Vitor Mendes, R. Andres Floto, Tom L. Blundell, Anthony G. Coyne, Chris Abell
Publikováno v:
ACS Infectious Diseases. 8:296-309
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6a26c6af4b6de128bd9f1582c73b377
https://doi.org/10.1021/acsinfecdis.1c00432
https://doi.org/10.1021/acsinfecdis.1c00432
Autor:
Albert B Jeon, Andrés Obregón-Henao, David F Ackart, Brendan K Podell, Juan M Belardinelli, Mary Jackson, Tuan V Nguyen, Meghan S Blackledge, Roberta J Melander, Christian Melander, Benjamin K Johnson, Robert B Abramovitch, Randall J Basaraba
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180925 (2017)
There is an urgent need to develop new drug treatment strategies to control the global spread of drug-sensitive and multidrug-resistant Mycobacterium tuberculosis (M. tuberculosis). The ß-lactam class of antibiotics is among the safest and most wide
Externí odkaz:
https://doaj.org/article/13b71f62b38642b8ae75712bb88ac78d
Autor:
Cecilia B. Di Capua, Juan M. Belardinelli, Hugo A. Carignano, María V. Buchieri, Cristian A. Suarez, Héctor R. Morbidoni
Publikováno v:
Microbiology spectrum. 10(4)
Mycolic acids, a hallmark of the genus Mycobacterium, are unique branched long-chain fatty acids produced by a complex biosynthetic pathway. Due to their essentiality and involvement in various aspects of mycobacterial pathogenesis, the synthesis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a40be5eed914da2f11759cce20cd852
https://pubmed.ncbi.nlm.nih.gov/35862962
https://pubmed.ncbi.nlm.nih.gov/35862962
Autor:
Haig Alexander Eskandarian, Yu-Xiang Chen, Chiara Toniolo, Juan M. Belardinelli, Zuzana Palcekova, Paul Ashby, Georg E. Fantner, Mary Jackson, John D. McKinney, Babak Javid
Invading microbes face a myriad of cidal mechanisms of phagocytes that inflict physical damage to microbial structures. How intracellular bacterial pathogens adapt to these stresses is not fully understood. Here, we report a new virulence mechanism b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6744a500c7da5416af21897f81ea1bdd
https://doi.org/10.1101/2022.04.06.487411
https://doi.org/10.1101/2022.04.06.487411
Autor:
Juan M, Belardinelli, Wei, Li, Kevin H, Martin, Michael J, Zeiler, Elena, Lian, Charlotte, Avanzi, Crystal J, Wiersma, Tuan Vu, Nguyen, Bhanupriya, Angala, Vinicius C N, de Moura, Victoria, Jones, Bradley R, Borlee, Christian, Melander, Mary, Jackson
Publikováno v:
International journal of molecular sciences. 23(6)
Biofilm growth is thought to be a significant obstacle to the successful treatment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d7b6263b7c34de8d0cdd88f4107a635
https://pubmed.ncbi.nlm.nih.gov/35328372
https://pubmed.ncbi.nlm.nih.gov/35328372
Autor:
Juan M. Belardinelli, Wei Li, Kevin H. Martin, Michael J. Zeiler, Elena Lian, Charlotte Avanzi, Crystal J. Wiersma, Tuan Vu Nguyen, Bhanupriya Angala, Vinicius C. N. de Moura, Victoria Jones, Bradley R. Borlee, Christian Melander, Mary Jackson
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 6; Pages: 2950
International Journal of Molecular Sciences; Volume 23; Issue 6; Pages: 2950
Biofilm growth is thought to be a significant obstacle to the successful treatment ofMycobacterium abscessusinfections. A search for agents capable of inhibitingM. abscessusbiofilms led to our interest in 2-aminoimidazoles and related scaffolds, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54df8ba09db06af7e46a10d8a49ba645