Zobrazeno 1 - 10
of 104
pro vyhledávání: '"M. Beierlein"'
Autor:
D. S. Engelke, X. O. Zhang, J. J. O’Malley, J. A. Fernandez-Leon, S. Li, G. J. Kirouac, M. Beierlein, F. H. Do-Monte
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Animals constantly balance seeking food with avoiding predators. Here, the authors report that CRF positive neurons in the paraventricular thalamus projecting to the nucleus accumbens in rats are an indispensable component of a feedback circuit that
Externí odkaz:
https://doaj.org/article/da0fbb3253a641e9a1dab25e6c597513
Autor:
Laura D. Wandner, Linda Porter, Andrew Siddons, Anthony F. Domenichiello, Jennifer M. Beierlein, Jane C. Atkinson, Leah Pogorzala, Guadalupe Aquino
Publikováno v:
The Journal of Pain. 23:370-378
The Helping to End Addiction Long-termSM Initiative (NIH HEAL InitiativeSM) is an aggressive trans-NIH effort to speed solutions to stem the national opioid public health crisis, including through improved pain management. Toward this end, the NIH HE
Autor:
Jennifer M. Beierlein, Clinton B. Wright, Amir P. Tamiz, Rebecca E. Hommer, Sarah A. Woller, Smriti Iyengar, Barbara I. Karp
Publikováno v:
Neurotherapeutics
Opioid-related death and overdose have now reached epidemic proportions. In response to this public health crisis, the National Institutes of Health (NIH) launched the Helping to End Addiction Long-term InitiativeSM, or NIH HEAL InitiativeSM, an aggr
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 9, Iss C, Pp 379-386 (2017)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
The long path from initial research on oligonucleotide therapies to approval of antisense products is not unfamiliar. This lag resembles those encountered with monoclonal antibodies, gene therapies, and many biological targets and is consistent with
Autor:
Ekaterina Galkina Cleary, Jennifer M. Beierlein, Fred D. Ledley, Laura M. McNamee, Navleen Surjit Khanuja
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance This report shows that NIH funding contributed to published research associated with every one of the 210 new drugs approved by the Food and Drug Administration from 2010–2016. Collectively, this research involved >200,000 years of gra
Autor:
Joseph A. DiMasi, Fred D. Ledley, Jennifer M. Beierlein, Michael J. Walsh, Kenneth I. Kaitin, Laura M. McNamee
Publikováno v:
Clinical therapeutics. 39(7)
Purpose This study examines the complete timelines of translational science for new cardiovascular therapeutics from the initiation of basic research leading to identification of new drug targets through clinical development and US Food and Drug Admi
Akademický článek
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Autor:
Jennifer M. Beierlein, Amy C. Anderson
Publikováno v:
Current Medicinal Chemistry. 18:5083-5094
Bacillus anthracis, the causative agent responsible for anthrax infections, poses a significant biodefense threat. There is a high mortality rate associated with untreated anthrax infections; specifically, inhalation anthrax is a particularly virulen
Publikováno v:
Biochemistry. 48:4100-4108
There is a significant need for new therapeutics to treat infections caused by the biodefense agent Bacillus anthracis. In pursuit of drug discovery against this organism, we have developed novel propargyl-linked inhibitors that target the essential
Autor:
Phillip M. Pelphrey, Adrienne E. Smith, Jennifer M. Beierlein, Dennis L. Wright, Nigel D. Priestley, Amy C. Anderson, Tammy M. Joska, David B. Bolstad, Kathleen M. Frey
Publikováno v:
Journal of Medicinal Chemistry. 51:7532-7540
Bacillus anthracis, the causative agent of anthrax, poses a significant biodefense danger. Serious limitations in approved therapeutics and the generation of resistance have produced a compelling need for new therapeutic agents against this organism.