Zobrazeno 1 - 10
of 13
pro vyhledávání: '"M. Behfar Ardehali"'
Autor:
Fu-Kai Hsieh, Sean P. Moran, Alan C. Mullen, Amin Mahpour, Isaac A. Klein, Kaveh Daneshvar, Chan Zhou, Sweta K Gupta, Wenyang Li, Brett M. Cook, Richard A. Young, Arcadia J. Kratkiewicz, Sabrina O L Cancelliere, M. Behfar Ardehali, Joshua V. Pondick, Robert E. Kingston
Publikováno v:
Nat Cell Biol
Cooperation between DNA, RNA and protein regulates gene expression and controls differentiation through interactions that connect regions of nucleic acids and protein domains and through the assembly of biomolecular condensates. Here, we report that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea0659ff6441def1ba93bf3a3a6692d
https://europepmc.org/articles/PMC8008247/
https://europepmc.org/articles/PMC8008247/
Autor:
Richard A. Young, Amin Mahpour, Sean P. Moran, Alan C. Mullen, Brett M. Cook, Kaveh Daneshvar, Joshua V. Pondick, Wenyang Li, Chan Zhou, Robert E. Kingston, Isaac A. Klein, M. Behfar Ardehali, Arcadia J. Kratkiewicz
Gene programs that control differentiation are regulated through the interplay between DNA, RNA, and protein. Cooperation among these fundamental cellular components can occur through highly structured interactions connecting domains formed by specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9a9823968b51dd748e5e153aa8589f
Autor:
Michael D. Blower, M. Behfar Ardehali, Carlos Perea-Resa, Manashree Damle, Robert E. Kingston
Publikováno v:
The Journal of Biological Chemistry
Elongin A (EloA) is an essential transcription factor that stimulates the rate of RNA polymerase II (Pol II) transcription elongation in vitro. However, its role as a transcription factor in vivo has remained underexplored. Here we show that in mouse
Publikováno v:
The Journal of Biological Chemistry
Elongin is an RNA polymerase II (RNAPII)-associated factor that has been shown to stimulate transcriptional elongation in vitro. The Elongin complex is thought to be required for transcriptional induction in response to cellular stimuli and to ubiqui
Autor:
John T. Lis, Amanda Mei, Katie L. Zobeck, Thomas Kusch, M. Behfar Ardehali, Matthieu J. Caron
Publikováno v:
The EMBO Journal. 30:2817-2828
Histone H3 lysine 4 trimethylation (H3K4me3) is a major hallmark of promoter-proximal histones at transcribed genes. Here, we report that a previously uncharacterized Drosophila H3K4 methyltransferase, dSet1, and not the other putative histone H3K4 m
Autor:
Anthony Anselmo, Sharmistha Kundu, Ruslan I. Sadreyev, M. Behfar Ardehali, Jesse C. Cochrane, Robert E. Kingston
Publikováno v:
Molecular Cell. 68:872-884.e6
Summary Polycomb repressive complex 2 (PRC2-EZH2) methylates histone H3 at lysine 27 (H3K27) and is required to maintain gene repression during development. Misregulation of PRC2 is linked to a range of neoplastic malignancies, which is believed to i
Autor:
Jie Yao, Steven J. Petesch, Watt W. Webb, John T. Lis, Karen Adelman, Nicholas J. Fuda, M. Behfar Ardehali
Publikováno v:
The EMBO Journal. 28:1067-1077
Several eukaryotic transcription factors have been shown to modulate the elongation rate of RNA polymerase II (Pol II) on naked or chromatin-reconstituted templates in vitro. However, none of the tested factors have been shown to directly affect the
Publikováno v:
Molecular Cell. 28(6):978-990
Transcription activation causes dramatic changes in a gene's compaction and macromolecular associations and, in some cases, triggers the translocation of the gene to a nuclear substructure. Here, we evaluate the location, movement, and transcriptiona
Autor:
M Behfar, Ardehali, Amanda, Mei, Katie L, Zobeck, Matthieu, Caron, John T, Lis, Thomas, Kusch
Publikováno v:
The EMBO journal. 30(14)
Histone H3 lysine 4 trimethylation (H3K4me3) is a major hallmark of promoter-proximal histones at transcribed genes. Here, we report that a previously uncharacterized Drosophila H3K4 methyltransferase, dSet1, and not the other putative histone H3K4 m
In the eukaryotic genome, the thousands of genes that encode messenger RNA are transcribed by a molecular machine called RNA polymerase II. Analysing the distribution and status of RNA polymerase II across a genome has provided crucial insights into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47459d80c4c0bbc6dda6397672d082d0
https://europepmc.org/articles/PMC2833331/
https://europepmc.org/articles/PMC2833331/