Zobrazeno 1 - 10
of 38
pro vyhledávání: '"M. Begusova"'
Publikováno v:
International Journal of Radiation Biology. 76:731-740
This study is aimed at comparing the radiosensitivity of a 21-mer DNA fragment in duplex and triplex form (Py x Pu duplex and Py x Pu:Py triplex) and to give insights into the fine structural features due to the different strandedness.The triplex sam
Publikováno v:
International Journal of Radiation Biology. 75:913-917
Purpose: To extend to a quadruplex the stochastic model of radiolytic attack previously applied to a quasi-random duplex DNA. Materials and methods: The quadruplex structure is obtained from the PDB databank (first structure from 201D entry). The pro
Autor:
Denise Sy, V. Michalik, M. Begusova, L. Tartier, Michel Charlier, C. Savoye, Melanie Spotheim-Maurizot
Publikováno v:
Journal de Chimie Physique et de Physico-Chimie Biologique. 95:674-681
Pour etudier l'influence de la structure de l'ADN sur la probabilite d'induire des coupures simple brin par les radiations ionisantes, l'attaque par les radicaux OH est simulee par la methode de Monte Carlo. Nous avons calcule les probabilites relati
Publikováno v:
International journal of radiation biology. 79(6)
To propose an improved version of RADACK, a stochastic simulation of radiolytic attack on DNA, that takes into account the reactivity of each amino acid of a specifically bound protein with hydroxyl radicals. To apply it to the natural lactose operat
Autor:
Séverine Eon, Françoise Culard, Melanie Spotheim-Maurizot, Michel Charlier, Denise Sy, M. Begusova
Publikováno v:
International journal of radiation biology. 77(6)
To calculate the probability of radiation-induced frank strand breakage (FSB) at each nucleotide in the Escherichia coli lac repressor-lac operator system using a simulation procedure. To compare calculated and experimental results. To asses the cont
Publikováno v:
International journal of radiation biology. 75(7)
To extend to a quadruplex the stochastic model of radiolytic attack previously applied to a quasi-random duplex DNA.The quadruplex structure is obtained from the PDB databank (first structure from 201D entry). The probabilities of OH* radical attack
Publikováno v:
International journal of radiation biology. 76(8)
To calculate the expected pattern of frank strand breaks (FSB) induced in the DNA of a nucleosome core particle (NCP) by the attack of radiolytic OH* radicals and to compare this with the experimental pattern of FSB induced by the in vitro irradiatio
Publikováno v:
International journal of radiation biology. 76(1)
To assess the influence of the intercalating drug ethidium bromide (EtBr) on the yields of single strand breaks (ssb) induced by fast neutrons in supercoiled pBR322 plasmid and in a linear DNA restriction fragment.The yield of ssb in the plasmid was
Publikováno v:
International journal of radiation biology. 72(2)
Using a 80 base pair DNA fragment, the sequence-dependence was compared for: (i) the probability of fast neutrons induced strand breakage, (ii) the accessibility of the H4'- and H5'-atoms to OH. attack, (iii) the width of the minor groove, and (iv) t
Publikováno v:
International Journal of Radiation Biology. 76:1575-1575