Environmental carcinogenesis: when Nrf2 and the anti-oxidant response would drive the clonal evolution in colorectal cancer

Autor: Laurence Huc, F. Pierre, F. Gueraud, R. Surya, S. Dalleau, M Baradat

Publikováno v: Toxicology Letters
Congress of the European-Societies-of-Toxicology (EUROTOX)-Toxicology Out of the Box
Congress of the European-Societies-of-Toxicology (EUROTOX)-Toxicology Out of the Box, Sep 2018, Brussels, Belgium. pp.S33, ⟨10.1016/j.toxlet.2018.06.1140⟩

International audience; During environmental carcinogenesis, the anti-oxidant response exerts a primordial role in the protection of normal cells against chemicals, toxins or secondary diet by-products. In the case of colorectal cancer CRC, according

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515fe076efa01e732c7a00679f9d4c67
https://hal.inrae.fr/hal-02618709

A central role for heme iron in colon carcinogenesis associated with red meat intake

Autor: Nathalie Naud, Fatima Z Chenni, Gunter G. C. Kuhnle, Isabelle Raymond-Letron, M Baradat, Raphaëlle L. Santarelli, Denis E. Corpet, Isabelle Jouanin, Françoise Guéraud, Sylviane Taché, Fabrice Pierre, Reggie Surya, Marc Audebert, Nadia M. Bastide, Ditte A. Hobbs

Publikováno v: Cancer Research
Cancer Research, 2015, 75 (5), pp.870-9. ⟨10.1158/0008-5472.CAN-14-2554⟩
Cancer Research, American Association for Cancer Research, 2015, 75 (5), pp.870-9. ⟨10.1158/0008-5472.CAN-14-2554⟩

Epidemiology shows that red and processed meat intake is associated with an increased risk of colorectal cancer. Heme iron, heterocyclic amines, and endogenous N-nitroso compounds (NOC) are proposed to explain this effect, but their relative contribu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5213755ffea957c8a8dc1079725f7aa5
https://hal.inrae.fr/hal-02637354

Cell death and diseases related to oxidative stress: 4-hydroxynonenal (HNE) in the balance

Autor: M Baradat, Laurence Huc, Françoise Guéraud, S Dalleau

Publikováno v: Cell Death and Differentiation
Cell Death and Differentiation, Nature Publishing Group, 2013, 20 (12), pp.1615-1630. ⟨10.1038/cdd.2013.138⟩

International audience; During the last three decades, 4-hydroxy-2-nonenal (HNE), a major alpha, beta-unsaturated aldehyde product of n-6 fatty acid oxidation, has been shown to be involved in a great number of pathologies such as metabolic diseases,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d655a97e91f30b2402542cafbf2da1
https://hal.inrae.fr/hal-02650840

4-Hydroxy-2(E)-nonenal metabolism differs in apc(+/+) cells and in apc(Min/+) cells: it may explain colon cancer promotion by heme iron

Autor: Mathilde Gieules, Fabrice Pierre, Sabine Dalleau, M Baradat, Laurence Huc, Sylviane Taché, Isabelle Jouanin, Cécile Canlet, J. Dupuy, Laurent Debrauwer, Françoise Guéraud

Publikováno v: Chemical Research in Toxicology
Chemical Research in Toxicology, American Chemical Society, 2011, 24 (11), pp.1984-1993. ⟨10.1021/tx2003036⟩

International audience; Animal and epidemiological studies suggest that dietary heme iron would promote colorectal cancer. Oxidative properties of heme could lead to the formation of cytotoxic and genotoxic secondary lipid oxidation products, such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e54318c489d57a3c3157f9936702abd
https://hal.inrae.fr/hal-02644375

Effects of diquat and fomasen applied alone and in combination with a nonylphenol polyethoxylate adjuvant on Lemna minor in aquatic indoor microcosms

Autor: Caroline Gorzerino, Georges Delous, Alphonse Quémeneur, Anne Hillenweck, Didier Azam, M Baradat, Thierry Caquet, Martine Ollitrault, Laurent Lagadic

Publikováno v: Ecotoxicology and Environmental Safety
Ecotoxicology and Environmental Safety, Elsevier, 2009, 72 (3), pp.802-810. ⟨10.1016/j.ecoenv.2008.08.001⟩

The influence of tank-mix adjuvants on pesticide toxicity remains largely unknown. Agral 90, a nonylphenol polyethoxylated tank-mix adjuvant, has been used with diquat (bipyridylium herbicide) and fomesafen (diphenyl-ether herbicide) in aquatic indoo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffdd041210d90f15eb8d52aed729129a
https://hal.archives-ouvertes.fr/hal-01453751