Evaluation of poly (lactic-co-glycolic acid) nanoparticles to improve the therapeutic efficacy of paclitaxel in breast cancer

Autor: Laura Cabeza, Mazen M. El-Hammadi, Raul Ortiz, Maria D. Cayero-Otero, Julia Jiménez-López, Gloria Perazzoli, Lucia Martin-Banderas, Jose M. Baeyens, Consolación Melguizo, Jose Prados

Publikováno v: BioImpacts, Vol 12, Iss 6, Pp 515-531 (2022)

Introduction: Paclitaxel (PTX) is a cornerstone in the treatment of breast cancer, the most common type of cancer in women. However, this drug has serious limitations, including lack of tissue-specificity, poor water solubility, and the development o

Externí odkaz: https://doaj.org/article/c093ddc4368f4964aa6cd6f64422ba52

Sigma-1 receptor curtails endogenous opioid analgesia during sensitization of TRPV1 nociceptors

Autor: M. Carmen Ruiz‐Cantero, Elsa Cortés‐Montero, Aakanksha Jain, Ángeles Montilla‐García, Inmaculada Bravo‐Caparrós, Jaehoon Shim, Pilar Sánchez‐Blázquez, Clifford J. Woolf, José M. Baeyens, Enrique J. Cobos

Publikováno v: British journal of pharmacology.

Background and Purpose: Peripheral sensitization contributes to pathological pain. While prostaglandin E2 (PGE2) and nerve growth factor (NGF) sensitize peptidergic C-nociceptors (TRPV1+), glial cell line-derived neurotrophic factor (GDNF) sensitizes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f53ee384ce7ad41944d841064342321b
https://pubmed.ncbi.nlm.nih.gov/36478100

Sigma-1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury

Autor: Inmaculada Bravo-Caparrós, José Miguel Vela, Josef M. Penninger, Enrique J. Cobos, Shane J. F. Cronin, Gloria Perazzoli, M. Carmen Ruiz-Cantero, José M. Baeyens, Mohamed Hamed, Francisco R. Nieto

Publikováno v: Digibug. Repositorio Institucional de la Universidad de Granada
instname
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)

Neuron-immune interaction in the dorsal root ganglia (DRG) plays a pivotal role in the neuropathic pain development after nerve injury. Sigma-1 receptor (Sig-1R) is expressed by DRG neurons but its role in neuropathic pain is not fully understood. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea194f14fa03329274c7a3cd3d871a18
http://hdl.handle.net/10481/67088

Visceral and somatic pain modalities reveal NaV1.7-independent visceral nociceptive pathways

Autor: Antonio Gaitán Torres, David C. Bulmer, Gordon McMurray, Francisco R. Nieto, Thomas Pitcher, James R.F. Hockley, Rafael González-Cano, Vincent Cibert-Goton, Wendy J. Winchester, Charles H. Knowles, Cian McGuire, Anna Wilbrey, José M. Baeyens, Sheridan McMurray, John N. Wood, Cruz Miguel Cendán, Miguel A. Tejada-Giraldez

Publikováno v: The Journal of Physiology. 595:2661-2679

Voltage-gated sodium channel NaV 1.7 is required for acute and inflammatory pain in mice and humans but its significance for visceral pain is unknown. Here we examine the role of NaV 1.7 in visceral pain processing and the development of referred hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90231123037a441fe3ada955783ad985
https://doi.org/10.1113/jp272837

Urinary bladder sigma-1 receptors: A new target for cystitis treatment

Autor: Eduardo Fernández-Segura, F.J. Cañizares, Antonia Artacho-Cordón, Cruz Miguel Cendán, Manuel Merlos, José M. Baeyens, Rafael González-Cano, Miguel Á. Tejada, Lucía Romero, Francisco R. Nieto

Publikováno v: Digibug. Repositorio Institucional de la Universidad de Granada
instname
Pharmacological Research

Supplementary material related to this article can be found, in the online version, at doi:https://doi.org/10.1016/j.phrs.2020.104724.
No adequate treatment is available for painful urinary bladder disorders such as interstitial cystitis/bladder

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0832e5b4b4d0b91d115c43f378a0b487
https://pubmed.ncbi.nlm.nih.gov/32105755