Zobrazeno 1 - 10
of 138
pro vyhledávání: '"M. Bachoo"'
Autor:
Xiaofei Gao, Zhaohuan Zhang, Tomoyuki Mashimo, Bo Shen, James Nyagilo, Hao Wang, Yihui Wang, Zhida Liu, Aditi Mulgaonkar, Xiao-Ling Hu, Sara G.M. Piccirillo, Ugur Eskiocak, Digant P. Davé, Song Qin, Yongjie Yang, Xiankai Sun, Yang-Xin Fu, Hui Zong, Wenzhi Sun, Robert M. Bachoo, Woo-ping Ge
Publikováno v:
Cell Reports, Vol 30, Iss 8, Pp 2489-2500.e5 (2020)
Summary: Emerging evidence suggests that crosstalk between glioma cells and the brain microenvironment may influence brain tumor growth. To date, known reciprocal interactions among these cells have been limited to the release of paracrine factors. C
Externí odkaz:
https://doaj.org/article/bbf1b45e59a14c7fa609bc4ef41b8bc0
Autor:
Dinesh K. Singh, Rahul K. Kollipara, Vamsidara Vemireddy, Xiao-Li Yang, Yuxiao Sun, Nanda Regmi, Stefan Klingler, Kimmo J. Hatanpaa, Jack Raisanen, Steve K. Cho, Shyam Sirasanagandla, Suraj Nannepaga, Sara Piccirillo, Tomoyuki Mashimo, Shan Wang, Caroline G. Humphries, Bruce Mickey, Elizabeth A. Maher, Hongwu Zheng, Ryung S. Kim, Ralf Kittler, Robert M. Bachoo
Publikováno v:
Cell Reports, Vol 18, Iss 4, Pp 961-976 (2017)
Efforts to identify and target glioblastoma (GBM) drivers have primarily focused on receptor tyrosine kinases (RTKs). Clinical benefits, however, have been elusive. Here, we identify an SRY-related box 2 (SOX2) transcriptional regulatory network that
Externí odkaz:
https://doaj.org/article/584c70e23319436aa0e06b23b2f7fe46
Autor:
Robert M. Bachoo, Jerry W. Shay, Woodring E. Wright, Bruce E. Mickey, Christopher J. Madden, Kimmo J. Hatanpaa, Elizabeth A. Maher, Brian M. Mcellin, Steve K. Cho, Calin O. Marian
Supplementary Data from The Telomerase Antagonist, Imetelstat, Efficiently Targets Glioblastoma Tumor-Initiating Cells Leading to Decreased Proliferation and Tumor Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae43f6e6e24372b8857fed87bf6684d
https://doi.org/10.1158/1078-0432.22446050.v1
https://doi.org/10.1158/1078-0432.22446050.v1
Autor:
Robert M. Bachoo, Jerry W. Shay, Woodring E. Wright, Bruce E. Mickey, Christopher J. Madden, Kimmo J. Hatanpaa, Elizabeth A. Maher, Brian M. Mcellin, Steve K. Cho, Calin O. Marian
Purpose: Telomerase activity is one of the hallmarks of cancer and is a highly relevant therapeutic target. The effects of a novel human telomerase antagonist, imetelstat, on primary human glioblastoma (GBM) tumor-initiating cells were investigated i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f35ea0c368c2cfe3b9f8729222e836a
https://doi.org/10.1158/1078-0432.c.6520634.v1
https://doi.org/10.1158/1078-0432.c.6520634.v1
Autor:
Amyn A. Habib, Russell O. Pieper, Robert M. Bachoo, Dawen Zhao, David A. Boothman, Debabrata Saha, Guanghua Xiao, Deepti B. Ramnarain, Jack M. Raisanen, Christopher J. Madden, Bruce E. Mickey, Yang Xie, Kimmo J. Hatanpaa, Seongmi Park
Nuclear factor-κB (NF-κB) activation may play an important role in the pathogenesis of cancer and also in resistance to treatment. Inactivation of the p53 tumor suppressor is a key component of the multistep evolution of most cancers. Links between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cf70236c2227d1c1e19ebd22a41fb47
https://doi.org/10.1158/0008-5472.c.6499883.v1
https://doi.org/10.1158/0008-5472.c.6499883.v1
Autor:
Sandeep Burma, Robert M. Bachoo, Nozomi Tomimatsu, Brandon Hahm, Bipasha Mukherjee, Cristel V. Camacho, Brian McEllin
Glioblastomas (GBM) are lethal brain tumors that are highly resistant to therapy. The only meaningful improvement in therapeutic response came from use of the SN1-type alkylating agent temozolomide in combination with ionizing radiation. However, no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f51c86b3fc4465bac07972c79120752
https://doi.org/10.1158/0008-5472.c.6500438
https://doi.org/10.1158/0008-5472.c.6500438
Autor:
Sandeep Burma, Robert M. Bachoo, Nozomi Tomimatsu, Brandon Hahm, Bipasha Mukherjee, Cristel V. Camacho, Brian McEllin
Supplementary Methods, Figures 1-8 from PTEN Loss Compromises Homologous Recombination Repair in Astrocytes: Implications for Glioblastoma Therapy with Temozolomide or Poly(ADP-Ribose) Polymerase Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8cd6f49d7faefd2463269092ec11a4
https://doi.org/10.1158/0008-5472.22383134.v1
https://doi.org/10.1158/0008-5472.22383134.v1
Autor:
Zhenghong Gao, Eric T. David, Tiffany W. Leong, Xiaoqing Li, Qi Cai, Juliet Mwirigi, Monica Giannotta, Elisabetta Dejana, John Wiggins, Sharada Krishnagiri, Robert M. Bachoo, Theodore J. Price, Zhengpeng Qin
The blood-spinal cord barrier (BSCB) tightly regulates molecular transport from the blood to the spinal cord. Herein, we present a novel approach for transient modulation of BSCB permeability and localized delivery of peptides into the spinal cord fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0df9198454d292a3e61bcc78aa55afd
https://doi.org/10.1101/2022.05.20.492752
https://doi.org/10.1101/2022.05.20.492752
Autor:
Edward P, Hackett, Bhavya R, Shah, Bingbing, Cheng, Evan, LaGue, Vamsidihara, Vemireddy, Manuel, Mendoza, Chenchen, Bing, Robert M, Bachoo, Kelvin L, Billingsley, Rajiv, Chopra, Jae Mo, Park
Publikováno v:
ACS Chem Neurosci
Transient disruption of the blood-brain barrier (BBB) with focused ultrasound (FUS) is an emerging clinical method to facilitate targeted drug delivery to the brain. The focal noninvasive disruption of the BBB can be applied to promote local delivery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33c33fb8c58c927a683bf09cfa0a231c
https://pubmed.ncbi.nlm.nih.gov/34291630
https://pubmed.ncbi.nlm.nih.gov/34291630
Autor:
Hans K Ghayee, Vikash J Bhagwandin, Victor Stastny, Arielle Click, Liang-Hao Ding, Dario Mizrachi, Ying S Zou, Raj Chari, Wan L Lam, Robert M Bachoo, Alice L Smith, Michael D Story, Stan Sidhu, Bruce G Robinson, Fiemu E Nwariaku, Adi F Gazdar, Richard J Auchus, Jerry W Shay
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65624 (2013)
Pheochromocytomas are rare tumors generally arising in the medullary region of the adrenal gland. These tumors release excessive epinephrine and norepinephrine resulting in hypertension and cardiovascular crises for which surgery is the only definiti
Externí odkaz:
https://doaj.org/article/7e8a696222644d8f8667020199bd460b