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Akademický článek

Modulation of Autophagy Influences the Function and Survival of Human Pancreatic Beta Cells Under Endoplasmic Reticulum Stress Conditions and in Type 2 Diabetes

Autor: M. Bugliani, S. Mossuto, F. Grano, M. Suleiman, L. Marselli, U. Boggi, P. De Simone, D. L. Eizirik, M. Cnop, P. Marchetti, V. De Tata

Publikováno v: Frontiers in Endocrinology, Vol 10 (2019)

Autophagy is the major mechanism involved in degradation and recycling of intracellular components, and its alterations have been proposed to cause beta cell dysfunction. In this study, we explored the effects of autophagy modulation in human islets

Externí odkaz: https://doaj.org/article/15970f60089d46f6982656baa4b41af9

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2136-P: Effects of Cytokine Exposure on the Proteome of Human Islets as Evaluated by Shotgun and 2DE Analysis

Autor: Lutgart Overbergh, Maria Rosa Mazzoni, Maurizio Ronci, Antonio Lucacchini, Chantal Mathieu, Mara Suleiman, Federica Ciregia, Decio L. Eizirik, Ugo Boggi, Laura Giusti, Carmela De Luca, L Marselli, M Bugliani, Paolo De Simone, Francesca Grano, Piero Marchetti

Publikováno v: Diabetes. 68

Pro-inflammatory cytokines (CYT) lead to several changes in human islet (HI) protein expression, but few data are available on CYT-induced alterations at the whole proteome level, including post-translational modifications (PTM). We used label-free s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31ae6dc615d46293a37a5907b3a6ceae
https://doi.org/10.2337/db19-2136-p

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Combinations of QTc-prolonging drugs: towards disentangling pharmacokinetic and pharmacodynamic effects in their potentially additive nature

Autor: A. D. Meid, I. Bighelli, S. Mächler, G. Mikus, G. Carrà, M. Castellazzi, C. Lucii, G. Martinotti, M. Nosè, G. Ostuzzi, T. Acciavatti, A. Adamo, A. Aguglia, C. Albanese, S. Baccaglini, F. Bardicchia, R. Barone, Y. Barone, F. Bartoli, C. Bergamini, F. Bertolini, S. Bolognesi, A. Bordone, P. Bortolaso, M. Bugliani, C. Calandra, S. Calò, G. Cardamone, M. Caroleo, E. Carra, D. Carretta, L. Chiocchi, E. Cinosi, M. Clerici, M. Corbo, E. Corsi, R. Costanzo, G. Costoloni, F. D’Arienzo, S. Debolini, A. De Capua, W. A. Di Napoli, M. Dinelli, E. Facchi, F. Fargnoli, F. Fiori, A. Franchi, F. Gardellin, C. Gastaldon, E. Gazzoletti, L. Ghio, M. Giacomin, M. Gregis, N. Iovieno, D. Koukouna, A. Lax, C. Lintas, A. Luca, M. Luca, M. Lussetti, M. Madrucci, N. Magnani, L. Magni, E. Manca, C. Martorelli, R. Mattafirri, C. Paladini, D. Papola, M. Percudani, G. Perini, P. Petrosemolo, M. Pezzullo, S. Piantanida, F. Pinna, K. Prato, D. Prestia, D. Quattrone, C. Reggianini, F. Restaino, M. Ribolsi, G. Rinosi, C. Rizzo, R. Rizzo, M. Roggi, G. Rossi, S. Rossi, S. Ruberto, M. Santi, R. Santoro, G. Sepede, M. S. Signorelli, F. Soscia, P. Staffa, M. Stilo, S. Strizzolo, F. Suraniti, N. Tavian, L. Tortelli, F. Tosoni, M. Valdagno, V. Zanobini, C. Barbui, W. E. Haefeli

Publikováno v: Therapeutic Advances in Psychopharmacology

Background:Whether arrhythmia risks will increase if drugs with electrocardiographic (ECG) QT-prolonging properties are combined is generally supposed but not well studied. Based on available evidence, the Arizona Center for Education and Research on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600a2a95c47666d814e664eb0b720e31
http://hdl.handle.net/10281/168798

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Autophagy in human type 2 diabetes pancreatic beta cells

Autor: Matilde Masini, Ugo Boggi, M. Bugliani, Lorella Marselli, S Del Guerra, R. Lupi, Piero Marchetti, Franco Filipponi, Pellegrino Masiello

Publikováno v: Diabetologia. 52:1083-1086

Beta cell loss contributes to type 2 diabetes, with increased apoptosis representing an underlying mechanism. Autophagy, i.e. the physiological degradation of damaged organelles and proteins, may, if altered, be associated with a distinct form of cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9813b3cec1e0ad50f01d59f98e256cee
https://doi.org/10.1007/s00125-009-1347-2

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