Individual Factors Including Age, BMI, and Heritable Factors Underlie Temperature Variation in Sickness and in Health

Autor: Jonathan Wolf, Janet M. Lord, Michela Antonelli, Benjamin J. Murray, Marc F. Osterdahl, Rose S. Penfold, M. B. Zazzara, Ruth C. E. Bowyer, Ellen J. Thompson, Maxim B. Freidin, Mary Ni Lochlainn, Carly Welch, Carole H. Sudre, Yu Xian Rachel Tan, Sebastien Ourselin, Marc Modat, Tonny Veenith, Claire J. Steves

Publikováno v: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
The journals of gerontology. Series A, Biological sciences and medical sciences, 77(9), 1890-1897. Oxford University Press
GSTT Covid Collaborative 2022, ' Individual Factors Including Age, BMI, and Heritable Factors Underlie Temperature Variation in Sickness and in Health : An Observational, Multi-cohort Study ', The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 77, no. 9, pp. 1890-1897 . https://doi.org/10.1093/gerona/glab295

Background Aging affects immunity, potentially altering fever response to infection. We assess effects of biological variables on basal temperature, and during COVID-19 infection, proposing an updated temperature threshold for older adults ≥65 year

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c311440fcef941e378521189440c23
http://www.scopus.com/inward/record.url?scp=85137138652&partnerID=8YFLogxK

99 Heritability of Temperature and the Effects of Ageing on Temperature Regulation: An Observational Multi-Cohort Study

Autor: M. B. Zazzara, Claire J. Steves, Tonny Veenith, Janet M. Lord, Rose S. Penfold, Marc F. Osterdahl

Publikováno v: Age and Ageing

Introduction Ageing affects homeostasis and immunosenescence, resulting in aberrant fever and immune responses to infection in older adults. This study assesses heritability of basal temperature and explores effects of ageing on basal temperature and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f4e8f52718a47e4eabbd7121410466
http://europepmc.org/articles/PMC7989624

Individual factors underlie temperature variation in sickness and in health: influence of age, BMI and genetic factors in a multi-cohort study

Autor: Ellen J. Thompson, Marc F. Osterdahl, Michela Antonelli, Tonny Veenith, Janet M. Lord, Mary Ni Lochlainn, Maxim B. Freidin, Marc Modat, Ruth C. E. Bowyer, Claire J. Steves, M. B. Zazzara, Gstt CovidCollaborative, Rose S. Penfold, Carly Welch, Carole H. Sudre, Sebastien Ourselin, Benjamin J. Murray, Jonathan Wolf, Yu Xian Rachel Tan

IntroductionAgeing affects immune function resulting in aberrant fever response to infection. We assess the effects of biological variables on basal temperature and temperature in COVID-19 infection, proposing an updated temperature threshold for old

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f3b2b4f8d14849a6a7e1f8838de5d81
https://doi.org/10.1101/2021.01.26.21250480

Probable delirium is a presenting symptom of COVID-19 in frail, older adults: a cohort study of 322 hospitalised and 535 community-based older adults

Autor: Finbarr C. Martin, Hannah Dooley, Amy L. Roberts, Ruth C. E. Bowyer, Massimo Mangino, Maxim B. Freidin, Mark S. Graham, Alessia Visconti, Mary Ni Lochlainn, Rose S. Penfold, Karla A. Lee, Benjamin J. Murray, Claire J. Steves, Kerrin S. Small, M. B. Zazzara, Marc Modat, Sebastien Ourselin, Carly Welch, Carole H. Sudre, Jonathan Wolf, Julia S. El-Sayed Moustafa

Publikováno v: Age and Ageing
Zazzara, M B, Penfold, R S, Roberts, A L, Lee, K A, Dooley, H, Sudre, C H, Welch, C, Bowyer, R C E, Visconti, A, Mangino, M, Freidin, M B, El-sayed Moustafa, J S, Small, K S, Murray, B, Modat, M, Graham, M S, Wolf, J, Ourselin, S, Martin, F C, Steves, C J & Lochlainn, M N 2021, ' Probable delirium is a presenting symptom of COVID-19 in frail, older adults : a cohort study of 322 hospitalised and 535 community-based older adults ', Age and Ageing, vol. 50, no. 1, pp. 40-48 . https://doi.org/10.1093/ageing/afaa223

Background Frailty, increased vulnerability to physiological stressors, is associated with adverse outcomes. COVID-19 exhibits a more severe disease course in older, comorbid adults. Awareness of atypical presentations is critical to facilitate early

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf22b95b39507dc0af18f9bff9eb77d6
https://pubmed.ncbi.nlm.nih.gov/32986799