Zobrazeno 1 - 10
of 128
pro vyhledávání: '"M. B. Rittenberg"'
Publikováno v:
The Journal of Immunology. 159:1293-1302
The extent to which somatic mutation impairs the Ig complementarity-determining region (CDR) and framework region (FRW) structure/function is not clear. Previously, we found that the VH CDR2 of the murine T15 Ab is highly sensitive to mutation; 56% (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bce5a1957d1ac8ce3a9515e98bc72a59
https://doi.org/10.4049/jimmunol.159.3.1293
https://doi.org/10.4049/jimmunol.159.3.1293
Publikováno v:
The Journal of Immunology. 157:4341-4346
We recently described mutants of the murine anti-phosphocholine Ab T15, with changes in heavy chain complementarity determining region 2 (HCDR2) that caused loss of secretion. Surprisingly, the T15 HCDR2 mutations did not alter secretion when placed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::272e8d33333354e24e2a998ea8559600
https://doi.org/10.4049/jimmunol.157.10.4341
https://doi.org/10.4049/jimmunol.157.10.4341
Publikováno v:
The Journal of Immunology. 148:339-346
Anti-phosphocholine (PC)-keyhole limpet hemacyanin hybridomas representative of a memory response that express the lambda 1 L chain isotype have a high reactivity to PC-protein. A common feature of these hybridomas possessing high affinity for PC-pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5b2ce9f23d68446292c62071db54fcc
https://doi.org/10.4049/jimmunol.148.2.339
https://doi.org/10.4049/jimmunol.148.2.339
Publikováno v:
The Journal of Immunology. 147:2359-2367
We describe three sets of natural (preimmune) polyreactive antibodies and Ag-induced antibodies that share the same VH-VL combinations. The amino acid homology in the VH and VL segments averaged 92%. These sets were found among 49 neonatal and adult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3330522972a1a88d8b4c565c2a636153
https://doi.org/10.4049/jimmunol.147.7.2359
https://doi.org/10.4049/jimmunol.147.7.2359
Publikováno v:
Annals of the New York Academy of Sciences. 780
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4562e886ee5d0e92a8dc7dadb895b70e
https://pubmed.ncbi.nlm.nih.gov/8602738
https://pubmed.ncbi.nlm.nih.gov/8602738
Autor:
A C, Buenafe, M B, Rittenberg
Publikováno v:
Immunology. 73(4)
We have analysed the serum antibody response of BALB/c mice to the organophosphorus toxin soman coupled to the protein carrier keyhole limpet haemocyanin (So-KLH) and compared the specificity of the serum antibodies to that of hybridomas described pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3fbe12571b223ae3e208ed45cbbc833e
https://pubmed.ncbi.nlm.nih.gov/1916892
https://pubmed.ncbi.nlm.nih.gov/1916892
Publikováno v:
The Journal of Immunology. 132:1323-1328
We investigated the heterogeneity of anti-phosphocholine (PC) antibodies present in human serum taken from individuals before and after immunization with a multivalent pneumococcal vaccine. The fine specificity of IgM, IgG, and IgA anti-PC antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcff718ce77272cb770dce88254d3e17
https://doi.org/10.4049/jimmunol.132.3.1323
https://doi.org/10.4049/jimmunol.132.3.1323
Publikováno v:
The Journal of Immunology. 129:1559-1562
Group I and group II variable regions expressed in the PC-KLH memory response may originate from distinct germ-line genes or group II may arise by somatic mutation of group I (TEPC 15) germ-line genes. A current version of the somatic mutation hypoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ac81d022f392b0b86c4de59ed82b14d
https://doi.org/10.4049/jimmunol.129.4.1559
https://doi.org/10.4049/jimmunol.129.4.1559
Autor:
T V Tittle, M B Rittenberg
Publikováno v:
The Journal of Immunology. 124:202-206
Spleen cells from mice primed with the thymus dependent (TD) antigen trinitrophenyl keyhole limpet hemocyanin several months earlier can be stimulated in vitro to produce an IgG anti-hapten response to TD as well as thymus independent (TI) forms of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5becd934795d6066872fbee219ef687a
https://doi.org/10.4049/jimmunol.124.1.202
https://doi.org/10.4049/jimmunol.124.1.202
Publikováno v:
The Journal of Immunology. 128:702-706
We examined the fine specificity of the memory response to phosphorylcholine (PC) using an enzyme-linked immunosorbent assay (ELISA) that measures the relative abilities of PC analogs to inhibit the binding of antibody to antigen. Along with the usua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54de0b9901db19978cc71748a3ff495b
https://doi.org/10.4049/jimmunol.128.2.702
https://doi.org/10.4049/jimmunol.128.2.702