Výsledky vyhledávání - "M. B. Perlman"

Thrombin-induced alterations in lung fluid balance in awake sheep

Autor: A. B. Malik, M. B. Perlman, G. D. Niehaus, S. K. Lo

Publikováno v: Journal of Applied Physiology. 58:1421-1427

We examined the effect of fibrinolysis depression on thrombin-induced pulmonary microembolism in awake sheep prepared with chronic lung lymph fistulas. Fibrinolysis was depressed by an intravenous infusion (100 mg) of tranexamic acid [trans-4-(Aminom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c36d563ef994cf5b58d392b0c27b2ed
https://doi.org/10.1152/jappl.1985.58.5.1421

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Ibuprofen prevents thrombin-induced lung vascular injury: mechanism of effect

Autor: M. B. Perlman, Arnold Johnson, Asrar B. Malik

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 252:H605-H614

We compared pulmonary vascular responses with thrombin-induced pulmonary microembolism in awake sheep pretreated with ibuprofen or meclofenamate. Control sheep with lung lymph fistulas (n = 6) were challenged with 80 U/kg of alpha-thrombin, the nativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84cd6d046b72668e9877dce74b4db11e
https://doi.org/10.1152/ajpheart.1987.252.3.h605

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Superoxide dismutase prevents the thrombin-induced increase in lung vascular permeability: role of superoxide in mediating the alterations in lung fluid balance

Autor: Frank A. Blumenstock, Asrar B. Malik, M. B. Perlman, Arnold Johnson

Publikováno v: Circulation Research. 59:405-415

We investigated the effects of superoxide dismutase (SOD) and SOD linked to Ficoll (mol. wt = 400,000) on the changes in pulmonary transvascular fluid and protein exchange following pulmonary microembolism induced with alpha-thrombin. Studies were ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23dd69fb5ddffb4c8eaa8180582d88dd
https://doi.org/10.1161/01.res.59.4.405

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Inflammatory Events after Fibrin Microembolization: Alterations in Alveolar Macrophage and Neutrophil Function

Autor: Joe G.N. Garcia, M. B. Perlman, William Jubiz, Thomas J. Ferro, Arnold Johnson, Asrar B. Malik

Publikováno v: American Review of Respiratory Disease. 137:630-635

We performed bronchoalveolar lavage (BAL) 0.5 to 24 h after thrombin-induced pulmonary microembolization in spontaneously breathing sheep to examine the inflammatory events that occur after pulmonary intravascular coagulation. Neutrophil alveolitis w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8b7247b1211b09085a23959c7ff95b
https://doi.org/10.1164/ajrccm/137.3.630

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Lipoxygenase products induce neutrophil activation and increase endothelial permeability after thrombin-induced pulmonary microembolism

Autor: Asrar B. Malik, M. B. Perlman, William Jubiz, Arnold Johnson

Publikováno v: Circulation Research. 64:62-73

We examined the mechanism of the neutrophil (PMN)-dependent increase in pulmonary vascular permeability to protein after thrombin-induced pulmonary microembolism. Humoral factors that activate PMNs after thrombin-induced pulmonary microembolism were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0a00ef967f9593b3549f8566cc4cc2
https://doi.org/10.1161/01.res.64.1.62

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Effect of prostacyclin on pulmonary vascular response to thrombin in awake sheep

Autor: Asrar B. Malik, S. K. Lo, M. B. Perlman

Publikováno v: Journal of Applied Physiology. 60:546-553

We determined the effects of infusion of prostacyclin (PGI2) and 6-alpha-carba-PGI2 (6-cPGI2), a stable PGI2 analogue, on pulmonary transvascular fluid and protein fluxes after intravascular coagulation induced by thrombin. Studies were made in contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c8c0ded37cada7c6c8ac9563c52cba
https://doi.org/10.1152/jappl.1986.60.2.546

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Pulmonary microvascular effects of arachidonic acid metabolites and their role in lung vascular injury

Autor: A B, Malik, M B, Perlman, J A, Cooper, T, Noonan, R, Bizios

Publikováno v: Federation proceedings. 44(1 Pt 1)

Arachidonic acid metabolites produced by cyclooxygenase and lipoxygenase pathways affect pulmonary transvascular fluid and protein fluxes after pulmonary microvascular injury. Some of these products may contribute to the increase microvascular endoth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3410d9d88b43b76ef8e6a8485b3638fb
https://pubmed.ncbi.nlm.nih.gov/2981732

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Lower respiratory tract abnormalities in rheumatoid interstitial lung disease. Potential role of neutrophils in lung injury

Autor: Joe G.N. Garcia, M. B. Perlman, B. A. Keogh, H. L. James, S. Zinkgraf

Publikováno v: The American review of respiratory disease. 136(4)

Although the etiology of rheumatoid interstitial lung disease (RILD) remains unknown, bronchoalveolar lavage (BAL) has been useful in studying potentially pathogenic mechanisms in this disorder. Previous investigations in patients with rheumatoid art

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4b690d944dc242e0c9028bcd70ede3
https://pubmed.ncbi.nlm.nih.gov/2821854

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1814 MEDIATORS AFFECTING NEUTROPHIL (PMN) FUNCTION ARE RELEASED AFTER PULMONARY INTRAVASCULAR COAGULATION

Autor: Asrar B. Malik, Arnold Johnson, M. B. Perlman

Publikováno v: Pediatric Research. 19:413A-413A

Awake sheep (n=4) with lung lymph fistulas were infused with thrombin (T)(80U/kg). Lung lymph was collected before and at 5 to 60 min. after T. PMN were isolated from donor sheep. Lymph chemotaxis was measured by chemotaxis under agarose. Superoxide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1da91ded3dc1cff45bca073164456d1d
https://doi.org/10.1203/00006450-198504000-01832

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