Výsledky vyhledávání - "M. B. Hodgins"

Changing patterns of gap junctional intercellular communication and connexin distribution in mouse epidermis and hair follicles during embryonic development

Autor: R, Choudhry, J D, Pitts, M B, Hodgins

Publikováno v: Developmental dynamics : an official publication of the American Association of Anatomists. 210(4)

In the mouse embryo between embryonic days 12 (E12) and 16, regular arrays of epidermal placodes on the mystacial pad develop into whisker follicles. This system was chosen for analysis of gap junctional intercellular communication during differentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ba3c1834883bbf465fd22f507c798f4
https://pubmed.ncbi.nlm.nih.gov/9415427

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Correlation of clinical, endocrine and molecular abnormalities with in vivo responses to high-dose testosterone in patients with partial androgen insensitivity syndrome

Autor: Douglas G Tincello, Philippa T. K. Saunders, Frederick C. W. Wu, M. B. Hodgins, N. B. Simpson, C. R. W. Edwards, T. B. Hargreaves

Publikováno v: Clinical endocrinology. 46(4)

OBJECTIVE: To investigate the responses of two patients previously diagnosed as Reifenstein's syndrome to graded high-dose testosterone in terms of hormone levels, nitrogen balance and sebum secretion and to attempt to correlate these parameters with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1e812b5a93333aba8be990ba020c34
https://pubmed.ncbi.nlm.nih.gov/9196614

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A practical approach to the detection of androgen receptor gene mutations and pedigree analysis in families with x-linked androgen insensitivity

Autor: Jan Trapman, Theo Hoogenboezem, Jan C. Oosterwijk, Albert O. Brinkmann, M.C.T. Verleun-Mooijman, H.F.B.M. Sleddens, D. J. J. Halley, H J Degenhart, C. Ris-Stalpers, M B Hodgins, Stenvert L. S. Drop

Publikováno v: Pediatric research, 36(2), 227-234. Lippincott Williams and Wilkins

Androgen insensitivity syndrome (AIS) is an X-linked disorder in which defects in the androgen receptor gene have prevented the normal development of both internal and external male structures in 46,XY individuals. This survey reports the analysis of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ebe0379990bb114a49775d43a511e6
https://pure.amc.nl/en/publications/a-practical-approach-to-the-detection-of-androgen-receptor-gene-mutations-and-pedigree-analysis-in-families-with-xlinked-androgen-insensitivity(6ec493bb-8d80-40bb-97f9-9ccb7985d941).html

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Immunohistochemical localization of estrogen receptors in the vulva and vagina

Autor: A B, MacLean, L A, Nicol, M B, Hodgins

Publikováno v: The Journal of reproductive medicine. 35(11)

A rat monoclonal antibody against human estrogen receptor (ER) was used to localize nuclear ER in frozen tissue sections with the peroxidase-antiperoxidase technique. Premenopausal and postmenopausal vaginal, vulvar and nongenital skin was examined.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::70894d093a0fba094a0e85ba245c3dac
https://pubmed.ncbi.nlm.nih.gov/2277362

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Aberrant splicing of androgen receptor mRNA results in synthesis of a nonfunctional receptor protein in a patient with androgen insensitivity

Autor: C. Ris-Stalpers, M. B. Hodgins, Albert O. Brinkmann, H. C. J. Van Rooij, H. U. Schweikert, N.D. Zegers, George G. J. M. Kuiper, H J Degenhart, P.W. Faber, Jan Trapman

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 87(20), 7866-7870. National Academy of Sciences

Androgen insensitivity is a disorder in which the correct androgen response in an androgen target cell is impaired. The clinical symptoms of this X chromosome-linked syndrome are presumed to be caused by mutations in the androgen receptor gene. We re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0298924be5870b2761b889b394b302
https://pure.amc.nl/en/publications/aberrant-splicing-of-androgen-receptor-mrna-results-in-synthesis-of-a-nonfunctional-receptor-protein-in-a-patient-with-androgen-insensitivity(3eab41f8-7b00-4884-bfb6-6422b2c9895b).html

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AN UNUSUAL PATTERN OF TESTOSTERONE METABOLISM IN TISSUE ASSOCIATED WITH A KERATIN-FILLED CUTANEOUS CYST

Autor: M. B. Hodgins, J. B. Hay

Publikováno v: Journal of Endocrinology. 67:267-273

SUMMARY Testosterone metabolism was studied in tissues associated with a keratin-filled cutaneous cyst. Instead of the 5α-reduced metabolites usually associated with skin steroid metabolism, considerable amounts of 5β-reduced steroids were found. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06992b57f932e432fe8b83f095cf0d04
https://doi.org/10.1677/joe.0.0670267

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DISTRIBUTION OF ANDROGEN METABOLIZING ENZYMES IN ISOLATED TISSUES OF HUMAN FOREHEAD AND AXILLARY SKIN

Autor: J. B. Hay, M. B. Hodgins

Publikováno v: Journal of Endocrinology. 79:29-39

The distribution of androgen metabolism in human skin was studied using tissues isolated either by direct dissection of axillary skin or by dissection of collagenase-digested forehead and axillary skin. All tissues (epidermis, sweat glands, sebaceous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a966b04b80932f24262d663ade64665
https://doi.org/10.1677/joe.0.0790029

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INCOMPLETE MASCULINIZATION DUE TO A DEFICIENCY OF 17β-HYDROXYSTEROID DEHYDROGENASE: COMPARISON OF PREPUBERTAL AND PERIPUBERTAL SIBLINGS

Autor: M. B. Hodgins, J. S. Scott, S. C. Wilson

Publikováno v: Clinical Endocrinology. 26:459-469

Incomplete masculinization due to a deficiency of 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) was investigated in siblings aged 4 years (Case 1) and 12 years (Case 2). Diagnosis was based on increased ratios of androstenedione (A) to testoster

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1bde24b4bc4620622316b7def2e8773
https://doi.org/10.1111/j.1365-2265.1987.tb00803.x

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Carrier detection in the testicular feminisation syndrome: deficient 5 alpha-dihydrotestosterone binding in cultured skin fibroblasts from the mothers of patients with complete androgen insensitivity

Autor: M B Hodgins, E M C Duke, D Ring

Publikováno v: Journal of Medical Genetics. 21:178-181

Specific binding of 5 alpha-dihydrotestosterone (androgen receptor activity) could not be detected in cultured genital skin fibroblasts (GSF) from two patients with complete androgen insensitivity (CAI). In GSF from the mother of one patient, androge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158e0dd54dec66debb9b53e01ef6efe4
https://doi.org/10.1136/jmg.21.3.178

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METABOLISM OF ANDROGENS IN VITRO BY HUMAN FOETAL SKIN

Autor: M. B. Hodgins, F. Sharp, J. B. Hay

Publikováno v: Journal of Endocrinology. 70:491-499

SUMMARY Fresh scalp, genital, chest and axillary skin from human foetuses of 12–41 weeks' maturity was incubated in Krebs' improved Ringer I medium with [7α-3H]dehydroepiandrosterone, [7α-3H]testosterone and [7α-3H]androstenedione. The metabolit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d0b9d2c7ea0ad2b60520bae6bce394
https://doi.org/10.1677/joe.0.0700491

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