Výsledky vyhledávání - "M. B. Finch-Arietta"

Characterization of a tight-binding MMP-3 inhibitor using improved fluorescence spectroscopy techniques

Autor: Robert L. Walsky, M. B. Finch-Arietta, A. C. Hanglow, W. Johnson, L. Lusch, N. Fotouhi

Publikováno v: Agents and actions.

Accurate kinetic characterization of stromelysin (MMP-3) inhibitors is critical in the design of potent inhibitors of this enzyme. We have successfully modified a previously described assay [1] which used an internally quenched peptide substrate (Dnp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85808efdd55fe7a836cdd35a76e3101d
https://pubmed.ncbi.nlm.nih.gov/8273564

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Peptides based on the conserved predomain sequence of matrix metalloproteinases inhibit human stromelysin and collagenase

Autor: N. Fotouhi, Robert L. Walsky, A. Lugo, A. C. Hanglow, M. B. Finch-Arietta, L. Lusch, M. Visnick

Publikováno v: Agents and actions.

Prostromelysin, a member of the family of matrix metalloproteinases, is secreted as a zymogen which is activated after cleavage of the His81-Phe82 bond. The 82 amino acid propeptide that is removed during activation contains 12 amino acids, MRKPRC75G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393c5a84654aef3175cd8a6b2204ef9e
https://pubmed.ncbi.nlm.nih.gov/8273554

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