Bacterial RNA Contributes to the Down-Modulation of MHC-II Expression on Monocytes/Macrophages Diminishing CD4+ T Cell Responses

Autor: M. Ayelén Milillo, Aldana Trotta, Agustina Serafino, José Luis Marin Franco, Fábio V. Marinho, Julieta Alcain, Melanie Genoula, Luciana Balboa, Sergio Costa Oliveira, Guillermo H. Giambartolomei, Paula Barrionuevo

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Brucella abortus, the causative agent of brucellosis, displays many resources to evade T cell responses conducive to persist inside the host. Our laboratory has previously showed that infection of human monocytes with B. abortus down-modulates the IF

Externí odkaz: https://doaj.org/article/a30c7fe1d2514ce590db3947c8295e72

Prokaryotic RNA Associated to Bacterial Viability Induces Polymorphonuclear Neutrophil Activation

Autor: Nahuel Rodriguez-Rodrigues, Luis A. Castillo, Verónica I. Landoni, Daiana Martire-Greco, M. Ayelén Milillo, Paula Barrionuevo, Gabriela C. Fernández

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)

Polymorphonuclear neutrophils (PMN) are the first cellular line of antibacterial host defense. They sense pathogens through recognition of pathogen-associated molecular patterns (PAMPs) by innate pattern recognition receptors, such as Toll-like recep

Externí odkaz: https://doaj.org/article/efeed10827824701be1265566443a589

Fatty acid oxidation of alternatively activated macrophages prevents foam cell formation, but Mycobacterium tuberculosis counteracts this process via HIF-1α activation.

Autor: Melanie Genoula, José Luis Marín Franco, Mariano Maio, Belén Dolotowicz, Malena Ferreyra, M Ayelén Milillo, Rémi Mascarau, Eduardo José Moraña, Domingo Palmero, Mario Matteo, Federico Fuentes, Beatriz López, Paula Barrionuevo, Olivier Neyrolles, Céline Cougoule, Geanncarlo Lugo-Villarino, Christel Vérollet, María Del Carmen Sasiain, Luciana Balboa

Publikováno v: PLoS Pathogens, Vol 16, Iss 10, p e1008929 (2020)

The ability of Mycobacterium tuberculosis (Mtb) to persist inside host cells relies on metabolic adaptation, like the accumulation of lipid bodies (LBs) in the so-called foamy macrophages (FM), which are favorable to Mtb. The activation state of macr

Externí odkaz: https://doaj.org/article/e3996610069c4233b5d8e0abeca9b2ff

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Fatty acid oxidation of alternatively activated macrophages prevents foam cell formation, but Mycobacterium tuberculosis counteracts this process via HIF-1α activation

Autor: Malena Ferreyra, Domingo Palmero, M. Ayelén Milillo, Beatriz López, José Luis Marín Franco, María del Carmen Sasiain, Paula Barrionuevo, Eduardo José Moraña, Luciana Balboa, Melanie Genoula, Federico Fuentes, Céline Cougoule, Mariano Maio, Rémi Mascarau, Mario José Matteo, Olivier Neyrolles, Belén Dolotowicz, Geanncarlo Lugo-Villarino, Christel Vérollet

Publikováno v: PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2020, 16 (10), pp.e1008929. ⟨10.1371/journal.ppat.1008929⟩
PLoS Pathogens, Vol 16, Iss 10, p e1008929 (2020)
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The ability of Mycobacterium tuberculosis (Mtb) to persist inside host cells relies on metabolic adaptation, like the accumulation of lipid bodies (LBs) in the so-called foamy macrophages (FM), which are favorable to Mtb. The activation state of macr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d37d085d38e68cedd4a92edb175b00
https://hal.archives-ouvertes.fr/hal-03017388