Zobrazeno 1 - 10
of 59
pro vyhledávání: '"M. Asif Amin"'
Autor:
Swarna Bale, Priyanka Verma, Bharath Yalavarthi, Scott Arthur Scarneo, Philip Hughes, M. Asif Amin, Pei-Suen Tsou, Dinesh Khanna, Timothy A.J. Haystead, Swati Bhattacharyya, John Varga
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Multiorgan fibrosis in systemic sclerosis (SSc) accounts for substantial mortality and lacks effective therapies. Lying at the crossroad of TGF-β and TLR signaling, TGF-β–activated kinase 1 (TAK1) might have a pathogenic role in SSc. We therefore
Externí odkaz:
https://doaj.org/article/b5bda06bbf254b1d930547a5f45e0f51
Autor:
Pei-Suen Tsou, Chenyang Lu, Mikel Gurrea-Rubio, Sei Muraoka, Phillip L. Campbell, Qi Wu, Ellen N. Model, Matthew E. Lind, Sirapa Vichaikul, Megan N. Mattichak, William D. Brodie, Jonatan L. Hervoso, Sarah Ory, Camila I. Amarista, Rida Pervez, Lucas Junginger, Mustafa Ali, Gal Hodish, Morgan M. O’Mara, Jeffrey H. Ruth, Aaron M. Robida, Andrew J. Alt, Chengxin Zhang, Andrew G. Urquhart, Jeffrey N. Lawton, Kevin C. Chung, Tristan Maerz, Thomas L. Saunders, Vincent E. Groppi, David A. Fox, M. Asif Amin
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 11 (2022)
CD13, an ectoenzyme on myeloid and stromal cells, also circulates as a shed, soluble protein (sCD13) with powerful chemoattractant, angiogenic, and arthritogenic properties, which require engagement of a G protein–coupled receptor (GPCR). Here we i
Externí odkaz:
https://doaj.org/article/e5e9835fa1944ab4a428208a7bd7d3dd
Autor:
Sirapa Vichaikul, Mikel Gurrea-Rubio, M. Asif Amin, Phillip L. Campbell, Qi Wu, Megan N. Mattichak, William D. Brodie, Pamela J. Palisoc, Mustafa Ali, Sei Muraoka, Jeffrey H. Ruth, Ellen N. Model, Dallas M. Rohraff, Jonatan L. Hervoso, Yang Mao-Draayer, David A. Fox, Dinesh Khanna, Amr H. Sawalha, Pei-Suen Tsou
Publikováno v:
JCI Insight, Vol 7, Iss 9 (2022)
Binding of the bromodomain and extraterminal domain proteins (BETs) to acetylated histone residues is critical for gene transcription. We sought to determine the antifibrotic efficacy and potential mechanisms of BET inhibition in systemic sclerosis (
Externí odkaz:
https://doaj.org/article/144c5e7d2e6a41519ccf4095bccbb0c0
Autor:
Jeffrey H. Ruth, Mikel Gurrea-Rubio, Kalana S. Athukorala, Stephanie M. Rasmussen, Daniel P. Weber, Peggy M. Randon, Rosemary J. Gedert, Matthew E. Lind, M. Asif Amin, Phillip L. Campbell, Pei-Suen Tsou, Yang Mao-Draayer, Qi Wu, Thomas M. Lanigan, Venkateshwar G. Keshamouni, Nora G. Singer, Feng Lin, David A. Fox
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Limitations of checkpoint inhibitor cancer immunotherapy include induction of autoimmune syndromes and resistance of many cancers. Since CD318, a novel CD6 ligand, is associated with the aggressiveness and metastatic potential of human cancers, we te
Externí odkaz:
https://doaj.org/article/f287e4446e9b405d899bf9971cadfab5
Autor:
Martin J. O’Brien, Qiang Shu, W.Alexander Stinson, Pei-Suen Tsou, Jeffrey H. Ruth, Takeo Isozaki, Phillip L. Campbell, Ray A. Ohara, Alisa E. Koch, David A. Fox, M. Asif Amin
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-8 (2018)
Abstract Background Galectin-9 (Gal-9) is a mammalian lectin secreted by endothelial cells that is highly expressed in rheumatoid arthritis synovial tissues and synovial fluid. Roles have been proposed for galectins in the regulation of inflammation
Externí odkaz:
https://doaj.org/article/4f63b3bffec345f58497e6ec184a9263
Mammalian Glycosylation Patterns Protect Citrullinated Chemokine MCP-1/CCL2 from Partial Degradation
Autor:
Olexandr Korchynskyi, Ken Yoshida, Nataliia Korchynska, Justyna Czarnik-Kwaśniak, Paul P. Tak, Ger J. M. Pruijn, Takeo Isozaki, Jeffrey H. Ruth, Phillip L. Campbell, M. Asif Amin, Alisa E. Koch
Publikováno v:
International Journal of Molecular Sciences, 24, 1-12
International Journal of Molecular Sciences, 24, 3, pp. 1-12
International Journal of Molecular Sciences; Volume 24; Issue 3; Pages: 1862
International Journal of Molecular Sciences, 24, 3, pp. 1-12
International Journal of Molecular Sciences; Volume 24; Issue 3; Pages: 1862
Peer reviewed: True
Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a potent chemotactic agent for monocytes, primarily produced by macrophages and endothelial cells. Significantly elevated levels of MCP-1/CCL2 were found in synovial fluids o
Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a potent chemotactic agent for monocytes, primarily produced by macrophages and endothelial cells. Significantly elevated levels of MCP-1/CCL2 were found in synovial fluids o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2149a315ca1c9dd87629887791881d45
http://hdl.handle.net/2066/290354
http://hdl.handle.net/2066/290354
Autor:
Azam Ahmed, Michael V. Volin, M. Asif Amin, Karol Palasiewicz, Chandana Tetali, Ryan K Zomorrodi, Hatem A Elshabrawy, Nadera J. Sweiss, Katrien Van Raemdonck, Sadiq Umar, Bianca Romay, Shiva Shahrara
Publikováno v:
Arthritis & Rheumatology. 73:2003-2014
OBJECTIVE In rheumatoid arthritis (RA), elevated serum interleukin-34 (IL-34) levels are linked with increased disease severity. IL-34 binds to 2 receptors, macrophage colony-stimulating factor receptor (M-CSFR) and syndecan 1, which are coexpressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::354151b18a6281d729c872bcb2b2fbcb
https://doi.org/10.1002/art.41792
https://doi.org/10.1002/art.41792
Autor:
Karol Palasiewicz, Imran Ahmad, Nadera J. Sweiss, Chandana Tetali, Michael V. Volin, Katrien Van Raemdonck, M. Asif Amin, Bianca Romay, Shiva Shahrara, Ryan K Zomorrodi, Sadiq Umar
Publikováno v:
Eur J Immunol
This study elucidates the mechanism of CCL25 and CCR9 in rheumatoid arthritis (RA). RA synovial fluid (SF) expresses elevated levels of CCL25 compared to OA SF and plasma from RA and normal. CCL25 was released into RA SF by fibroblasts (FLS) and macr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5f8828c5c058f79a4a109195522ffd
https://doi.org/10.1002/eji.202048681
https://doi.org/10.1002/eji.202048681
Autor:
Rachel L Morgan, Nilofar Behbahani-Nejad, Judith Endres, M Asif Amin, Nick J Lepore, Yuxuan Du, Andrew Urquhart, Kevin C Chung, David A Fox
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162008 (2016)
Aminopeptidase N/CD13 is highly expressed by fibroblast like synoviocytes (FLS) and may play a role in rheumatoid arthritis (RA). CD13 was previously detected in human synovial fluid where it was significantly increased in RA compared to osteoarthrit
Externí odkaz:
https://doaj.org/article/37eb550c9b1c479280afc2873c1fa45a
Autor:
M. Asif Amin, Feng Lin, Nora G. Singer, David A. Fox, Phillip L. Campbell, Stephanie M. Rasmussen, Daniel P. Weber, Kalana S. Athukorala, Yan Li, Jeffrey H. Ruth
Publikováno v:
Arthritis Rheumatol
OBJECTIVE CD6 is an important regulator of T cell function that interacts with the ligands CD166 and CD318. To further clarify the significance of CD6 in rheumatoid arthritis (RA), we examined the effects of targeting CD6 in the mouse model of collag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3d32d744ad34510bfde245cf281098
https://doi.org/10.1002/art.41288
https://doi.org/10.1002/art.41288