Zobrazeno 1 - 10
of 1 556
pro vyhledávání: '"M. Ashley"'
Autor:
Pratik Rajesh Chheda, Grant T. Cooling, Sondra F. Dean, Jonah Propp, Kathryn F. Hobbs, M. Ashley Spies
Publikováno v:
Communications Chemistry, Vol 4, Iss 1, Pp 1-13 (2021)
Protein-ligand binding can induce the formation of cryptic allosteric pockets not found in the unbound protein, but predicting this computationally can be challenging. Here a combined computational and experimental workflow identifies ligands for H.
Externí odkaz:
https://doaj.org/article/edbf1a0fa6f2470bb1785b0b7f6c0b60
Autor:
M. Ashley Hudson, Steve W. Lockless
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Despite the ever-growing antibiotic resistance crisis, the rate at which new antimicrobials are being discovered and approved for human use has rapidly declined over the past 75 years. A barrier for advancing newly identified antibiotics bey
Externí odkaz:
https://doaj.org/article/0e63d75649634a04827930977d15d641
Autor:
Hanzhi Zhang, Yaping Pan, Liya Hu, M. Ashley Hudson, Katrina S. Hofstetter, Zhichun Xu, Mingqiang Rong, Zhao Wang, B. V. Venkataram Prasad, Steve W. Lockless, Wah Chiu, Ming Zhou
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
TrkH is a bacterial ion channel that is regulated by nucleotides and its associated protein TrkA. Here the authors present ADP and ATP bound TrkH-TrkA structures, which reveal the mechanism for the transmission of nucleotide-induced conformational ch
Externí odkaz:
https://doaj.org/article/8f5a444b3e2548a29ca6d697a5a934a9
Autor:
Pauline Latzer, Henning Zelba, Florian Battke, Annekathrin Reinhardt, Borong Shao, Oliver Bartsch, Armin Rabsteyn, Johannes Harter, Martin Schulze, Thomas Okech, Alexander Golf, Christina Kyzirakos-Feger, Simone Kayser, Natalia Pieper, Magdalena Feldhahn, Julian Wünsche, Christian Seitz, Dirk Hadaschik, Claus Garbe, Till-Karsten Hauser, Christian la Fougère, Dirk Biskup, Dawn Brooke, David Parker, Uwe M. Martens, Gerald Illerhaus, Deborah T. Blumenthal, Ryan Merrell, Luisa Sánchez Lorenzo, Máté Hidvégi, Paula de Robles, Sied Kebir, William W. Li, Vincent W. Li, Matthew Williams, Alexandra M. Miller, Santosh Kesari, Michael Castro, Annick Desjardins, David M. Ashley, Henry S. Friedman, Patrick Y. Wen, Elisabeth C. Neil, Fabio M. Iwamoto, Bence Sipos, Karsten Geletneky, Lars Zender, Martin Glas, David A. Reardon, Saskia Biskup
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Current treatment outcome of patients with glioblastoma (GBM) remains poor. Following standard therapy, recurrence is universal with limited survival. Tumors from 173 GBM patients are analysed for somatic mutations to generate a personalized
Externí odkaz:
https://doaj.org/article/98a07e6f1b4647369483ebef527a8f94
Publikováno v:
ACS Central Science, Vol 1, Iss 7, Pp 364-373 (2015)
Externí odkaz:
https://doaj.org/article/ddb67d1e76064d2b804d17666c953032
Autor:
Zhang, Yuzhou, Martin, Bertha, Spies, M. Ashley, Roberts, Sarah M., Nott, Joel, Goodfellow, Renee X., Nelson, Angela F.M., Blain, Samantha J., Redondo, Elena, Nester, Carla M., Smith, Richard J.H.
Publikováno v:
In Kidney International February 2024 105(2):328-337
Autor:
Michael A Sun, Haipei Yao, Qing Yang, Christopher J Pirozzi, Vidyalakshmi Chandramohan, David M Ashley, Yiping He
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0299820 (2024)
Targeting endolysosomes is a strategy extensively pursued for treating cancers, including glioblastomas (GBMs), on the basis that the intact function of these subcellular organelles is key to tumor cell autophagy and survival. Through gene expression
Externí odkaz:
https://doaj.org/article/744d6e5623f04a11bead05c2b93942ac
Akademický článek
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Publikováno v:
In DNA Repair December 2022 120
Akademický článek
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