Germinal‐center kinase‐like kinase co‐crystal structure reveals a swapped activation loop and C‐terminal extension

Autor: Marcotte, Douglas, Rushe, Mia, M. Arduini, Robert, Lukacs, Christine, Atkins, Kateri, Sun, Xin, Little, Kevin, Cullivan, Michael, Paramasivam, Murugan, Patterson, Thomas A., Hesson, Thomas, D. McKee, Timothy, May‐Dracka, Tricia L., Xin, Zhili, Bertolotti‐Ciarlet, Andrea, Bhisetti, Govinda R., Lyssikatos, Joseph P., Silvian, Laura F.

Germinal-center kinase-like kinase (GLK, Map4k3), a GCK-I family kinase, plays multiple roles in regulating apoptosis, amino acid sensing, and immune signaling. We describe here the crystal structure of an activation loop mutant of GLK kinase domain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a11736e263c5e85cda9b1df70861ec17
https://europepmc.org/articles/PMC5275742/

Germinal-center kinase-like kinase co-crystal structure reveals a swapped activation loop and C-terminal extension.

Autor: Marcotte D; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142., Rushe M; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142., M Arduini R; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142., Lukacs C; Beryllium Discovery Corp., 3 Preston Court, Bedford, MA, 01730., Atkins K; Beryllium Discovery Corp., 3 Preston Court, Bedford, MA, 01730., Sun X; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142., Little K; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142., Cullivan M; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142., Paramasivam M; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142., Patterson TA; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142., Hesson T; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142., D McKee T; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142., May-Dracka TL; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142., Xin Z; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142., Bertolotti-Ciarlet A; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142., Bhisetti GR; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142., Lyssikatos JP; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142., Silvian LF; Department of Drug Discovery, Biogen Inc., 115 Binney Street, Cambridge, MA, 02142.

Publikováno v: Protein science : a publication of the Protein Society [Protein Sci] 2017 Feb; Vol. 26 (2), pp. 152-162. Date of Electronic Publication: 2016 Oct 21.