Zobrazeno 1 - 10
of 218
pro vyhledávání: '"M. Alkondon"'
Publikováno v:
Alzheimer Disease & Associated Disorders. 15:S19-S25
Impaired cholinergic function in the central nervous system is an early feature of Alzheimer disease (AD). Currently, cholinergic deficit is usually corrected by increasing the amount of acetylcholine in the synapse by inhibiting acetylcholinesterase
Autor:
M Alkondon, Alfred Maelicke, Edna F. R. Pereira, Christoph Ullmer, Edson X. Albuquerque, Marek Samochocki
Publikováno v:
Cholinergic Mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14289785d16a6a06835066bf982bfe0d
https://doi.org/10.3109/9780203493878-45
https://doi.org/10.3109/9780203493878-45
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783642630279
Although the psychopharmacological effects of nicotine have been known since the last century, it was not until the end of the 1980s that neuronal nicotinic acetylcholine receptors (nAChRs) were found to be functional in the central nervous system (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78ef12e3982fed20df39355f9a6f55a3
https://doi.org/10.1007/978-3-642-57079-7_13
https://doi.org/10.1007/978-3-642-57079-7_13
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 284(3)
In our study, evidence is provided that strychnine, a competitive antagonist at glycine-gated Cl- channels, is also a potent competitive antagonist at native alpha-7-containing, alpha-bungarotoxin-sensitive nicotinic acetylcholine receptor (nAChRs).
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 283(3)
In the present study we investigated electrophysiologically the nicotinic responses of pyramidal neurons and interneurons visualized by infrared-assisted videomicroscopy and fluorescence in the CA1 field of hippocampal slices obtained from 8- to 24-d
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 279(3)
To assess the density and distribution of functional nicotinic acetylcholine receptors (nAChRs) and gamma-aminobutyric acid (GABA) receptors on hippocampal neurons, we have combined infrared videomicroscopy with a nanorobotic micromanipulator system
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 278(3)
The presence of functional nicotinic acetylcholine receptors (nAChRs) on cultured neurons of the rat olfactory bulb was evaluated using the whole-cell patch-clamp technique. Application of acetylcholine (ACh) to 78% of the tested olfactory bulb neuro
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 278(3)
In the present study, the patch-clamp technique was applied to rat hippocampal neurons or myoballs in culture to study the actions of alpha-conotoxin-ImI on the native alpha-bungarotoxin-sensitive, presumably alpha 7-bearing, neuronal nicotinic recep
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(1)
Applying the whole-cell mode of the patch-clamp technique to cultured hippocampal neurons, we demonstrated that extracellular Ca++ modulates the activation and inactivation of type IA nicotinic currents, ie., the currents subserved by alpha-bungaroto
Autor:
E X, Albuquerque, E F, Pereira, R, Bonfante-Cabarcas, M, Marchioro, H, Matsubayashi, M, Alkondon, A, Maelicke
Publikováno v:
Progress in brain research. 109