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Akademický článek

Pharmacokinetic Evaluation of New Drugs Using a Multi-Labelling Approach and PET Imaging: Application to a Drug Candidate with Potential Application in Neuromuscular Disorders

Autor: Rossana Passannante, Vanessa Gómez-Vallejo, Maialen Sagartzazu-Aizpurua, Laura Vignau Arsuaga, Pablo Marco-Moreno, Garazi Aldanondo, Ainara Vallejo-Illarramendi, Pablo Aguiar, Unai Cossío, Abraham Martín, Jonas Bergare, Lee Kingston, Charles S. Elmore, Miguel Angel Morcillo, Pablo Ferrón, Jesus M. Aizpurua, Jordi Llop

Publikováno v: Biomedicines, Vol 11, Iss 2, p 253 (2023)

Background and objective: The determination of pharmacokinetic properties of new chemical entities is a key step in the process of drug development. Positron emission tomography (PET) is an ideal technique to obtain both biodistribution and pharmacok

Externí odkaz: https://doaj.org/article/ed7d132499034dc9b7f57f0c9ecdfc0f

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From Bench to Cell: A Roadmap for Assessing the Bioorthogonal 'Click' Reactivity of Magnetic Nanoparticles for Cell Surface Engineering

Autor: Javier Idiago-López, Eduardo Moreno-Antolín, Maite Eceiza, Jesús M. Aizpurua, Valeria Grazú, Jesús M. de la Fuente, Raluca M. Fratila

Publikováno v: Bioconjugate Chemistry. 33:1620-1633

In this work, we report the use of bioorthogonal chemistry, specifically the strain-promoted click azide–alkyne cycloaddition (SPAAC) for the covalent attachment of magnetic nanoparticles (MNPs) on living cell membranes. Four types of MNPs were pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f963562ae5bcb12c4e9eaf2d73bc52
https://doi.org/10.1021/acs.bioconjchem.2c00230

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Akademický článek

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Discovery of a novel family of FKBP12 'reshapers' and their use as calcium modulators in skeletal muscle under nitro-oxidative stress

Autor: Garazi Aldanondo, Maite Eceiza, José I. Miranda, Ainara Vallejo-Illarramendi, Maialen Sagartzazu-Aizpurua, Pablo Marco-Moreno, Aitziber Irastorza, Pablo Ferrón, Jesus M. Aizpurua, Adolfo López de Munain, Haizpea Lasa-Fernández, Endika Torres, Naroa Dadie

Publikováno v: European Journal of Medicinal Chemistry. 213:113160

The hypothesis of rescuing FKBP12/RyR1 interaction and intracellular calcium homeostasis through molecular “reshaping” of FKBP12 was investigated. To this end, novel 4-arylthioalkyl-1-carboxyalkyl-1,2,3-triazoles were designed and synthesized, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66a6ca5e17c6c75233ec206da4a3755
https://doi.org/10.1016/j.ejmech.2021.113160

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Antitumor magnetic hyperthermia induced by RGD-functionalized Fe3O4 nanoparticles, in an experimental model of colorectal liver metastases

Autor: Jesus M. Aizpurua, Maite Insausti, Borja Herrero de la Parte, Ignacio García-Alonso, Jose Javier Echevarría-Uraga, Maialen Sagartzazu, Alberto Saiz-López, Mireia Irazola, Oihane Arriortua, José Ángel García, Luis Lezama, Nestor Etxebarria, Eneko Garaio, Fernando Plazaola

Publikováno v: Beilstein Journal of Nanotechnology
Beilstein Journal of Nanotechnology, Vol 7, Iss 1, Pp 1532-1542 (2016)

This work reports important advances in the study of magnetic nanoparticles (MNPs) related to their application in different research fields such as magnetic hyperthermia. Nanotherapy based on targeted nanoparticles could become an attractive alterna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b3f2d91089bccf593e57ed3016b2f3
http://europepmc.org/articles/PMC5238624

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Cationic 1,2,3-Triazolium Alkynes: Components To Enhance 1,4-Regioselective Azide–Alkyne Cycloaddition Reactions

Autor: Jesus M. Aizpurua, José I. Miranda, Maialen Sagartzazu-Aizpurua, Yuri Reyes, Zaira Monasterio

Publikováno v: Organic Letters. 18:788-791

4-Alkynyl-1,2,3-triazolium cations undergo thermal [3 + 2] cycloaddition reactions with azides roughly 50- to 100-fold faster than comparable noncharged alkynes. Further, the reaction is highly 1,4-regioselective (dr up to 99:1) owing to the selectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0336e91a9e67f76901247236ff0d3100
https://doi.org/10.1021/acs.orglett.6b00055

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RGD-Functionalized Fe3O4 nanoparticles for magnetic hyperthermia

Autor: María del Puerto Morales, Luis Lezama, Maite Eceiza, Maialen Sagartzazu-Aizpurua, Maite Insausti, Izaskun Gil de Muro, Raluca M. Fratila, Rocío Costa, Eneko Garaio, Jesús M. de la Fuente, Oihane K. Arriortua, Jesus M. Aizpurua

Publikováno v: Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Digital.CSIC. Repositorio Institucional del CSIC

To improve the selectivity of magnetic nanoparticles for tumor treatment by hyperthermia, Fe3O4 nanoparticles have been functionalized with a peptide of the type arginine-glycine-aspartate (RGD) following a "click" chemistry approach. The RGD peptide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a828fd2140e7afe5eafdde67412301f
http://hdl.handle.net/10261/181288

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Covalent immobilisation of magnetic nanoparticles on surfaces via strain-promoted azide–alkyne click chemistry

Autor: Marcos Navascuez, José I. Miranda, Jesus M. Aizpurua, Javier Idiago-López, Jesús M. de la Fuente, Raluca M. Fratila, Maite Eceiza

Publikováno v: New J. Chem.
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Digital.CSIC. Repositorio Institucional del CSIC

Herein we report the synthesis of “clickable” magnetic nanoparticles (MNPs) stable in suspension in physiological media for bioorthogonal click chemistry applications. These MNPs incorporate into their coating a cyclooctynyl derivative for strain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd815fbe39aeac1a6891276db820f6b9
http://hdl.handle.net/10261/181851

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