Zobrazeno 1 - 10
of 11
pro vyhledávání: '"M. Agostina Santoro"'
Autor:
M. Agostina Santoro, Jill Carmody Garrison, Joseph Brancale, Scott Lajoie, Lee M. Kaplan, Sriram Machineni
Publikováno v:
Diabetes. 67
Roux-en-Y gastric bypass (RYGB) leads to long-term weight loss and diabetes remission. Animal studies have shown that RYGB changes the physiology of energy regulation to favor a lower defended fat mass. To explore these effects, we developed a mouse
Autor:
Amanda T. Mah, M. Agostina Santoro, Amy E. Bortvedt, P. Kay Lund, Sarah F. Andres, J. Adeola Keku, R. Eric Blue
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 308:G100-G111
The insulin receptor (IR) regulates nutrient uptake and utilization in multiple organs, but its role in the intestinal epithelium is not defined. This study developed a mouse model with villin-Cre (VC) recombinase-mediated intestinal epithelial cell
Autor:
Amanda T. Mah, Shengli Ding, Sarah F. Andres, Laurianne Van Landeghem, Emily C. Moorefield, R. Eric Blue, M. Agostina Santoro
Publikováno v:
Aging (Albany NY)
Intestinal epithelial stem cells (IESCs) are critical to maintain intestinal epithelial function and homeostasis. We tested the hypothesis that aging promotes IESC dysfunction using old (18-22 months) and young (2-4 month) Sox9-EGFP IESC reporter mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde5ef95403cb249f3f346b675281c73
Autor:
R. Eric Blue, M. Agostina Santoro, Laurianne Van Landeghem, Sarah F. Andres, P. Kay Lund, Amanda T. Mah
Current views suggest that apoptosis eliminates genetically damaged cells that may otherwise form tumors. Prior human studies link elevated insulin and reduced apoptosis to risk of colorectal adenomas. We hypothesized that hyperinsulinemia associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39861fed0391039792840b6a961cd5f8
https://europepmc.org/articles/PMC4593818/
https://europepmc.org/articles/PMC4593818/
Autor:
Amanda T. Mah, Laurianne Van Landeghem, Jeffrey J. Dehmer, M. Agostina Santoro, Kirk K. McNaughton, Scott T. Magness, Adrienne E. Krebs, Michael A. Helmrath, P. Kay Lund
Insulin-like growth factor 1 (IGF1) has potent trophic effects on normal or injured intestinal epithelium, but specific effects on intestinal stem cells (ISCs) are undefined. We used Sox9-enhanced green fluorescent protein (EGFP) reporter mice that p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10666546074316420ac32ff769640467
https://europepmc.org/articles/PMC4478798/
https://europepmc.org/articles/PMC4478798/
Autor:
Joseph A. Galanko, Robert S. Sandler, Sarah F. Andres, M. Agostina Santoro, P. Kay Lund, Temitope O. Keku
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 23(10)
Background: Hyperinsulinemia resulting from obesity and insulin resistance is associated with increased risk of many cancers, but the biology underlying this risk is unclear. We hypothesized that increased mRNA levels of the insulin-like growth facto
Autor:
M. Agostina Santoro, Amanda Mah, James G. Simmons, P. Kay Lund, Laurianne Van Landeghem, Sarah F. Bortvedt
Publikováno v:
The FASEB Journal. 27
Autor:
Amanda T. Mah, M. Agostina Santoro, James G. Simmons, Sarah F. Andres, Laurianne Van Landeghem, P. Kay Lund
Despite evidence for the impact of insulin on intestinal epithelial physiology and pathophysiology, the expression patterns, roles, and regulation of insulin receptor (IR) and IR isoforms in the intestinal epithelium are not well characterized. IR-A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206926962158c7036fcc638e230c6d43
Autor:
Laurianne Van Landeghem, Amanda T. Mah, Sarah F. Bortvedt, M. Agostina Santoro, P. Kay Lund, Scott T. Magness
Publikováno v:
The FASEB Journal. 26
Autor:
Amanda T. Mah, Adrienne E. Krebs, Jeffrey J. Dehmer, Scott T. Magness, M. Agostina Santoro, Kirk K. McNaughton, P. Kay Lund, Adam D. Gracz, Brooks Scull, Laurianne Van Landeghem
Recent identification of intestinal epithelial stem cell (ISC) markers and development of ISC reporter mice permit visualization and isolation of regenerating ISCs after radiation to define their functional and molecular phenotypes. Previous studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a6d0ea9ef7305d6a37982ce1d5fe0f9
https://europepmc.org/articles/PMC3362093/
https://europepmc.org/articles/PMC3362093/