Zobrazeno 1 - 6
of 6
pro vyhledávání: '"M. Abid Masood"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3682-3687
The generation of novel CRTH2 ligands in heavily congested chemical space, by de novo design of libraries is disclosed. Novel (1719) compounds across seven libraries were synthesised. More than 100 of these compounds showed binding potency
Autor:
Elizabeth Farrant, Torren M. Peakman, Manuel Perez, Mark E. Bunnage, M. Abid Masood, Inaki Morao, Marc Bazin, Sally-Ann Fancy
Publikováno v:
ChemInform. 43
Mifepristone (I) and antalarmin (V) are used as substrates for the diversification of drug molecules using plate-based chemical screens.
Autor:
Francesca Perrucio, M. Abid Masood, Graham Smith, Charles E. Mowbray, M. J. Gardner, Helen Kenyon-Edwards, Charlotte Alice Louise Lane, Rhys M. Jones, Andrew Simon Bell, Wai L. Liu, Andrew C. Mansfield, Matthew D. Selby, Nick Clarke, Christopher D. Brown, Rachel Osborne
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(21)
We describe the identification of a potent, selective lead series that shows antagonism against the human histamine H4 receptor from thirteen actives identified in an HTS as part of a hit to lead program. By focusing on ligand efficiency and concurre
Autor:
Manuel Perez, Mark E. Bunnage, Elizabeth Farrant, Sally-Ann Fancy, Inaki Morao, Torren M. Peakman, Marc Bazin, M. Abid Masood
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(1)
A series of C-H functionalisation plate-based chemical screens and other C-H activation protocols were developed for the chemical diversification of drug molecules. In this Letter, metalloporphyrin and other catalytic oxidation systems are described
Akademický článek
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Autor:
Abid Masood M; Pfizer Worldwide Medicinal Chemistry, Sandwich Laboratories, Sandwich, UK. mabidmasood@gmail.com, Gardner M, Dack K, Winpenny D, Lunn G
Publikováno v:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Jun 01; Vol. 22 (11), pp. 3682-7. Date of Electronic Publication: 2012 Apr 20.