Zobrazeno 1 - 10 of 259 pro vyhledávání: '"M. AMICO-ROXAS"'
1
Synthesis and pharmacological evaluation of 1-methyl-5- [substituted-4(3H)-oxo-1,2,3-benzotriazin-3-yl]-1H-pyrazole-4-acetic acid derivatives
Autor: M. Amico-Roxas, Onofrio Migliara, Salvatore Plescia, Benedetta Maggio, Vincenza Maria Catena Cutuli, Domenico Schillaci, Demetrio Raffa, Giuseppe Daidone, Antonina Caruso
Publikováno v: Il Farmaco. 53:350-356
Several new 1-methyl-5-[substituted-4-oxo-1,2,3-benzotriazin-3-yl] -1H-pyrazole-4-acetic acids and their ethyl ester derivatives were prepared. The compounds were tested for analgesic and antiinflammatory activities, acute toxicity, ulcerogenic effec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85be966199c55fbd98653d833d84cd92
https://doi.org/10.1016/s0014-827x(98)00034-2
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2
Synthesis and pharmacological study of ethyl 1-methyl-5-[2-substituted-4-oxo-3(4H)-quinazolinyl]-1H-pyrazole-4-acetates
Autor: Vmc Cutuli, Benedetta Maggio, Demetrio Raffa, M. Amico-Roxas, Salvatore Plescia, A. Caruso, Giuseppe Daidone, M. L. Bajardi
Publikováno v: European Journal of Medicinal Chemistry. 29:707-711
A number of new ethyl 1-methyl-5-[4-oxo-3(4 H )-quinazolinyl]-1 H -pyrazole-4-acetates substituted at the 2 position of the quinazolinone ring were prepared. The compounds were tested for analgesic and antiinflammatory activities, as well as for thei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::caa357454bfb289425db4dcd66247b08
https://doi.org/10.1016/0223-5234(94)90033-7
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3
Pyrazolothiazolopyrimidine derivatives as a novel class of anti-inflammatory or antinociceptive agents: synthesis, structural characterization and pharmacological evaluation
Autor: Vincenza Maria Catena Cutuli, Salvatore Guccione, Giuseppe Romeo, M. Amico-Roxas, G Uccello Barretta, Filippo Russo, S Pucci, A. Caruso
Publikováno v: European Journal of Medicinal Chemistry. 28:363-376
As a part of a research program on anti-inflammatory-analgesic compounds, pyrazolothiazolopyrimidines 5a-f and 5g-i were prepared by cyclodehydration in 98% H 2 SO 4 or PPA of the corresponding 6-thioketomethylene-substituted-4-hydroxy-pyrazolo[3,4-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a464c816b811804be44f796706a0a8d5
https://doi.org/10.1016/0223-5234(93)90123-v
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7
ChemInform Abstract: Synthesis and Pharmacological Properties of Benzothiazole, 1,3,4- Oxadiazole and 1,3,4-Thiadiazole Derivatives
Autor: Maria Santagati, E. Di Pietro, Antonina Caruso, Filippo Russo, Maria N. Modica, Vincenza Maria Catena Cutuli, Andrea Santagati, M Amico-Roxas
Publikováno v: ChemInform. 26
The reaction of the 2-amino-substituted 1,3,4-oxadiazoles 9, 10 and the benzothiazoles 11, 12 with ethyl cyanoacetate is described. The obtained cyanoacetamide derivatives 13-16 gave the benzylidene derivatives 18-21 by condensation with benzaldehyde
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd2930f2784613dbc73e935834eda028
https://doi.org/10.1002/chin.199518135
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9
ChemInform Abstract: Synthesis and Pharmacological Evaluation of 1-Methyl-5- [substituted-4(3H)-oxo-1,2,3-benzotriazin-3-yl]-1H-pyrazole-4-acetic Acid Derivatives
Autor: Domenico Schillaci, M. Amico-Roxas, Benedetta Maggio, Giuseppe Daidone, Onofrio Migliara, Demetrio Raffa, Vincenza Maria Catena Cutuli, Salvatore Plescia, Antonina Caruso
Publikováno v: ChemInform. 29
Several new 1-methyl-5-[substituted-4-oxo-1,2,3-benzotriazin-3-yl]-1H-pyrazole-4-acetic acids and their ethyl ester derivatives were prepared. The compounds were tested for analgesic and antiinflammatory activities, acute toxicity, ulcerogenic effect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1dc93dce9515913801edf8b244204618
https://doi.org/10.1002/chin.199843180
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10
Grapefruit juice effects on the bioavailability of cyclosporin-A in rats
Autor: N G, Mangano, V M, Cutuli, A, Caruso, E, De Bernardis, M, Amico-Roxas
Publikováno v: European review for medical and pharmacological sciences. 5(1)
Previous studies indicate that blood levels of cyclosporin-A are increased by concomittant administration of grapefruit juice in healthy subjects and patients. It was suggested that grapefruit juice could inhibit the metabolism of cyclosporin-A by CY
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::288c3ef834868ee7c19e33c0fd31ddae
https://pubmed.ncbi.nlm.nih.gov/11860217
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