Zobrazeno 1 - 10
of 110
pro vyhledávání: '"M. A. Van Der Pol"'
Autor:
Lynn van Olst, Alwin Kamermans, Sem Halters, Susanne M. A. van der Pol, Ernesto Rodriguez, Inge M. W. Verberk, Sanne G. S. Verberk, Danielle W. R. Wessels, Carla Rodriguez-Mogeda, Jan Verhoeff, Dorine Wouters, Jan Van den Bossche, Juan J. Garcia-Vallejo, Afina W. Lemstra, Maarten E. Witte, Wiesje M. van der Flier, Charlotte E. Teunissen, Helga E. de Vries
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-21 (2024)
Abstract Background Alzheimer’s disease (AD) is the most frequent cause of dementia. Recent evidence suggests the involvement of peripheral immune cells in the disease, but the underlying mechanisms remain unclear. Methods We comprehensively mapped
Externí odkaz:
https://doaj.org/article/bbeaac8f21914591a0b29202e34aed6d
Inflammation-induced TRPV4 channels exacerbate blood–brain barrier dysfunction in multiple sclerosis
Autor:
Cathrin E. Hansen, Alwin Kamermans, Kevin Mol, Kristina Berve, Carla Rodriguez-Mogeda, Wing Ka Fung, Bert van het Hof, Ruud D. Fontijn, Susanne M. A. van der Pol, Laura Michalick, Wolfgang M. Kuebler, Boyd Kenkhuis, Willeke van Roon-Mom, Wolfgang Liedtke, Britta Engelhardt, Gijs Kooij, Maarten E. Witte, Helga E. de Vries
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-20 (2024)
Abstract Background Blood–brain barrier (BBB) dysfunction and immune cell migration into the central nervous system (CNS) are pathogenic drivers of multiple sclerosis (MS). Ways to reinstate BBB function and subsequently limit neuroinflammation pre
Externí odkaz:
https://doaj.org/article/20142c75d08c47bfb64eb7ea8bb2e9c3
Autor:
Carla Rodriguez-Mogeda, Zoë Y. G. J. van Lierop, Susanne M. A. van der Pol, Loet Coenen, Laura Hogenboom, Alwin Kamermans, Ernesto Rodriguez, Jack van Horssen, Zoé L. E. van Kempen, Bernard M. J. Uitdehaag, Charlotte E. Teunissen, Maarten E. Witte, Joep Killestein, Helga E. de Vries
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-17 (2023)
Abstract Background Recent studies suggest that extended interval dosing of ocrelizumab, an anti-B cell therapy, does not affect its clinical effectiveness in most patients with multiple sclerosis (MS). However, it remains to be established whether c
Externí odkaz:
https://doaj.org/article/3f86be80f38742afbf3232690c390a1c
Autor:
Juan M. Ilarregui, Gijs Kooij, Ernesto Rodríguez, Susanne M. A. van der Pol, Nathalie Koning, Hakan Kalay, Joost C. van der Horst, Sandra J. van Vliet, Juan J. García-Vallejo, Helga E. de Vries, Yvette van Kooyk
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)
Abstract Background Multiple sclerosis (MS) involves a misdirected immune attack against myelin in the brain and spinal cord, leading to profound neuroinflammation and neurodegeneration. While the mechanisms of disease pathogenesis have been widely s
Externí odkaz:
https://doaj.org/article/22f87aeffcb24a268513be628fe3e17d
Autor:
Wissam Beaino, Bieneke Janssen, Gijs Kooij, Susanne M. A. van der Pol, B. van Het Hof, Jack van Horssen, Albert D. Windhorst, Helga E. de Vries
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-16 (2017)
Abstract Background Microglia are major players in the pathogenesis of multiple sclerosis (MS) and may play a dual role in disease progression. The activation status of microglia in vivo is highly dynamic and occurs as a continuum, with the pro-infla
Externí odkaz:
https://doaj.org/article/486a905d11334969992e19ca79e96e34
Autor:
Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Pascal J. H. Kusters, Susanne M. A. van der Pol, Barbara Zarzycka, Priscilla D. A. M. Heijnen, Linda Beckers, Myrthe den Toom, Marion J. J. Gijbels, Louis Boon, Christian Weber, Helga E. de Vries, Gerry A. F. Nicolaes, Christine D. Dijkstra, Gijs Kooij, Esther Lutgens
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-14 (2017)
Abstract Background The influx of leukocytes into the central nervous system (CNS) is a key hallmark of the chronic neuro-inflammatory disease multiple sclerosis (MS). Strategies that aim to inhibit leukocyte migration across the blood-brain barrier
Externí odkaz:
https://doaj.org/article/3098d45e563e46008b1ee78f986c3e30
Autor:
Elien Wouters, Nienke M. de Wit, Jasmine Vanmol, Susanne M. A. van der Pol, Bert van het Hof, Daniela Sommer, Melanie Loix, Dirk Geerts, Jan Ake Gustafsson, Knut R. Steffensen, Tim Vanmierlo, Jeroen F. J. Bogie, Jerome J. A. Hendriks, Helga E. de Vries
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Dysfunction of the blood-brain barrier (BBB) contributes significantly to the pathogenesis of several neuroinflammatory diseases, including multiple sclerosis (MS). Potential players that regulate BBB function are the liver X receptors (LXRs), which
Externí odkaz:
https://doaj.org/article/56fc8933ec1142a69ee5c39bf8b09233
Autor:
Sabela Rodríguez-Lorenzo, Susanne M. A. van der Pol, Helga E. de Vries, Sandra Amor, Maarten E. Witte, Jack van Horssen, Julia Konings, Gijs Kooij, Alwin Kamermans
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-13 (2020)
Acta Neuropathologica Communications
Rodríguez-Lorenzo, S, Konings, J, Van Der Pol, S, Kamermans, A, Amor, S, Van Horssen, J, Witte, M, Kooij, G & De Vries, H E 2020, ' Inflammation of the choroid plexus in progressive multiple sclerosis : Accumulation of granulocytes and T cells ', Acta neuropathologica communications, vol. 8, no. 1, 9 . https://doi.org/10.1186/s40478-020-0885-1
Acta neuropathologica communications, 8(1):9. BioMed Central
Acta Neuropathologica Communications
Rodríguez-Lorenzo, S, Konings, J, Van Der Pol, S, Kamermans, A, Amor, S, Van Horssen, J, Witte, M, Kooij, G & De Vries, H E 2020, ' Inflammation of the choroid plexus in progressive multiple sclerosis : Accumulation of granulocytes and T cells ', Acta neuropathologica communications, vol. 8, no. 1, 9 . https://doi.org/10.1186/s40478-020-0885-1
Acta neuropathologica communications, 8(1):9. BioMed Central
The choroid plexus (CP) is strategically located between the peripheral blood and the cerebrospinal fluid, and is involved in the regulation of central nervous system (CNS) homeostasis. In multiple sclerosis (MS), demyelination and inflammation occur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa17b7122b5c306945ca18a22660462
https://doaj.org/article/8c7ddcfe2bec45a086daa724750ab49d
https://doaj.org/article/8c7ddcfe2bec45a086daa724750ab49d
Autor:
Gijs Kooij, Ernesto Rodríguez, Alwin Kamermans, Lynn van Olst, Carla Rodriguez-Mogeda, Susanne M. A. van der Pol, Sabela Rodríguez-Lorenzo, Helga E. de Vries
Multiple sclerosis (MS) is a chronic demyelinating disease characterised by immune cell infiltration resulting in lesions that preferentially affect periventricular areas of the brain. Despite research efforts to define the role of various immune cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d114b0f0f8878467adb0a408dc948fd0
https://doi.org/10.1101/2021.09.17.460741
https://doi.org/10.1101/2021.09.17.460741
Autor:
Sabela, Rodríguez-Lorenzo, Lynn, van Olst, Carla, Rodriguez-Mogeda, Alwin, Kamermans, Susanne M A, van der Pol, Ernesto, Rodríguez, Gijs, Kooij, Helga E, de Vries
Publikováno v:
eLife. 11
Multiple sclerosis (MS) is a chronic demyelinating disease characterised by immune cell infiltration resulting in lesions that preferentially affect periventricular areas of the brain. Despite research efforts to define the role of various immune cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::97afb72d1e459ff765c2b080a7cb8208
https://pubmed.ncbi.nlm.nih.gov/35536009
https://pubmed.ncbi.nlm.nih.gov/35536009