Zobrazeno 1 - 10
of 288
pro vyhledávání: '"M. A. Surani"'
Autor:
João Pedro Alves-Lopes, Frederick C.K. Wong, Walfred W.C. Tang, Wolfram H. Gruhn, Navin B. Ramakrishna, Geraldine M. Jowett, Kirsi Jahnukainen, M. Azim Surani
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111907- (2023)
Summary: Human primordial germ cells (hPGCs), the precursors of sperm and eggs, are specified during weeks 2−3 after fertilization. Few studies on ex vivo and in vitro cultured human embryos reported plausible hPGCs on embryonic day (E) 12−13 and
Externí odkaz:
https://doaj.org/article/2727f3d06d114c409f080de4eeeff162
Autor:
Toshihiro Kobayashi, Teppei Goto, Mami Oikawa, Makoto Sanbo, Fumika Yoshida, Reiko Terada, Naoko Niizeki, Naoyo Kajitani, Kanako Kazuki, Yasuhiro Kazuki, Shinichi Hochi, Hiromitsu Nakauchi, M. Azim Surani, Masumi Hirabayashi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The uptake of donor pluripotent stem cells (PSCs) in hosts of different species and subsequent germline transmission is very inefficient. Here, the authors show, using Prdm14 gene depleted rat host blastocysts to remove functional sperm, that germlin
Externí odkaz:
https://doaj.org/article/9eb88f2e20b34fab81b008931d8f11b3
Autor:
Anastasiya Sybirna, Walfred W. C. Tang, Merrick Pierson Smela, Sabine Dietmann, Wolfram H. Gruhn, Ran Brosh, M. Azim Surani
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
PRDM14 is a critical transcription factor for mouse primordial germ cell specification, but its role in human remains unclear. Here, PRDM14 protein depletion using auxin-inducible degron uncovers a critical role for human germ cell specification, but
Externí odkaz:
https://doaj.org/article/89513bd8995b4d72af1095f2f4ba77c1
Autor:
Baojiang Wu, Lin Li, Bojiang Li, Junpeng Gao, Yanglin Chen, Mengyi Wei, Zhiqing Yang, Baojing Zhang, Shudong Li, Kexin Li, Changshan Wang, M. Azim Surani, Xihe Li, Fuchou Tang, Siqin Bao
Publikováno v:
Stem Cell Reports, Vol 14, Iss 2, Pp 241-255 (2020)
Summary: Inhibitors of Mek1/2 and Gsk3β, known as 2i, and, together with leukemia inhibitory factor, enhance the derivation of embryonic stem cells (ESCs) and promote ground-state pluripotency (2i/L-ESCs). However, recent reports show that prolonged
Externí odkaz:
https://doaj.org/article/d798f89b5d5c482893bda3d0b35d75ea
Autor:
Priscila Ramos-Ibeas, Fei Sang, Qifan Zhu, Walfred W. C. Tang, Sarah Withey, Doris Klisch, Liam Wood, Matt Loose, M. Azim Surani, Ramiro Alberio
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Lineage segregation from conception to gastrulation has been mapped at the single cell level in mouse, human and monkey. Here, the authors provide a comprehensive analysis of porcine preimplantation development using single cell RNA-seq; mapping meta
Externí odkaz:
https://doaj.org/article/aa29d00c859347f6bccca210653ecca1
Autor:
Qifan Zhu, Fei Sang, Sarah Withey, Walfred Tang, Sabine Dietmann, Doris Klisch, Priscila Ramos-Ibeas, Haixin Zhang, Cristina E. Requena, Petra Hajkova, Matt Loose, M. Azim Surani, Ramiro Alberio
Publikováno v:
Cell Reports, Vol 34, Iss 6, Pp 108735- (2021)
Summary: Investigations of the human germline and programming are challenging because of limited access to embryonic material. However, the pig as a model may provide insights into transcriptional network and epigenetic reprogramming applicable to bo
Externí odkaz:
https://doaj.org/article/eb691efd76104f4a97615cd06174a463
Autor:
Jamie A. Hackett, Yun Huang, Ufuk Günesdogan, Kristjan A. Gretarsson, Toshihiro Kobayashi, M. Azim Surani
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Primordial Germ Cell-Like Cells (PGCLCs) are an in vitro model for primordial germ cell development. Here, the authors couple a novel compound reporter with CRISPR screening to identify key genes for exit from pluripotency and acquisition of PGCLC fa
Externí odkaz:
https://doaj.org/article/5c34654d52b24b38beedd6ab9c107982
Autor:
Man Zhang, Harry G. Leitch, Walfred W.C. Tang, Nicola Festuccia, Elisa Hall-Ponsele, Jennifer Nichols, M. Azim Surani, Austin Smith, Ian Chambers
Publikováno v:
Cell Reports, Vol 22, Iss 2, Pp 332-339 (2018)
Summary: The transcription factors (TFs) Nanog and Esrrb play important roles in embryonic stem cells (ESCs) and during primordial germ-cell (PGC) development. Esrrb is a positively regulated direct target of NANOG in ESCs that can substitute qualita
Externí odkaz:
https://doaj.org/article/4af805fa2a50420993ccde52a768d491
Autor:
Masako Tada, Takamasa Ito, Musashi Kubiura-Ichimaru, Fumihito Miura, Shinpei Yamaguchi, Shoji Tajima, M. Azim Surani, Takashi Ito
DNA methyltransferases and TET enzymes dynamically regulate the DNA methylation-demethylation cycles during mouse embryonic development. DNMT1 maintains cell-specific DNA methylation after DNA replication. However, little is known about the physiolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e12cadf3deb5cb2fe9aa2ec0ee8e3d8c
https://doi.org/10.21203/rs.3.rs-2788282/v1
https://doi.org/10.21203/rs.3.rs-2788282/v1
Publikováno v:
Stem Cell Reports, Vol 8, Iss 6, Pp 1645-1658 (2017)
Embryonic stem cells (ESCs) are characterized by the pluripotent capacity to generate all embryonic lineages. Here, we show that ESCs can occupy a spectrum of distinct transcriptional and epigenetic states in response to varied extrinsic conditions.
Externí odkaz:
https://doaj.org/article/c4fa1883084d4d8b8f86cc7e15ce071f