Výsledky vyhledávání - "M. A. Shulepko"

Akademický článek

Selective targeting of α7 nicotinic acetylcholine receptor by synthetic peptide mimicking loop I of human SLURP-1 provides efficient and prolonged therapy of epidermoid carcinoma in vivo

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

α7-Type nicotinic acetylcholine receptor (α7-nAChR) promotes the growth and metastasis of solid tumors. Secreted Ly6/uPAR-Related Protein 1 (SLURP-1) is a specific negative modulator of α7-nAChR produced by epithelial cells. Here, we investigated

Externí odkaz: https://doaj.org/article/68ca419785d04cd79f6b4a41671b974e

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Recombinant production and structure-function study of ts1 toxin from the Brazilian scorpion Tityus serrulatus

Autor: Z. O. Shenkarev, M. A. Shulepko, S. Peigneur, M. Yu. Myshkin, A. A. Berkut, A. A. Vassilevski, J. Tytgat, E. N. Lyukmanova, M. P. Kirpichnikov

Publikováno v: Доклады Академии наук. 484:112-116

This work introduces an effective bacterial system for the production of β-toxin Ts1, the main component of the Brazilian scorpion Tityus serrulatus venom. Recombinant toxin and its 15N-labeled analogue are obtained by direct expression of the synth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::524c09f3873b13fda3c4ad29c102e5b5
https://doi.org/10.31857/s0869-56524841112-116

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Human secreted proteins SLURP-1 and SLURP-2 control the growth of epithelial cancer cells via interactions with nicotinic acetylcholine receptors

Autor: E N, Lyukmanova, M L, Bychkov, G V, Sharonov, A V, Efremenko, M A, Shulepko, D S, Kulbatskii, Z O, Shenkarev, A V, Feofanov, D A, Dolgikh, M P, Kirpichnikov

Publikováno v: British journal of pharmacology. 175(11)

BACKGROUND AND PURPOSE: Nicotinic acetylcholine receptors (nAChRs) are a promising target for development of new anticancer therapies. Here we have investigated the effects of the endogenous human proteins SLURP‐1 and SLURP‐2, antagonists of nACh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cba0bf9d4b6f1ed91a18a08f1d8837a0
https://pubmed.ncbi.nlm.nih.gov/29505672

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Akademický článek

Venom-derived peptides for breaking through the glass ceiling of drug development.

Autor: Freuville, Lou¹ (AUTHOR), Matthys, Chloé² (AUTHOR), Quinton, Loïc¹ (AUTHOR) loic.quinton@uliege.be, Gillet, Jean-Pierre² (AUTHOR) loic.quinton@uliege.be

Publikováno v: Frontiers in Chemistry. 2024, p1-37. 37p.

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[Bacterial expression of water-soluble domain of Lynx1, endogenic neuromodulator of human nicotinic acetylcholine receptors]

Autor: M A, Shulepko, E N, Liukmanova, I E, Kasheverov, D A, Dolgikh, V I, Tsetlin, M P, Kirpichnikov

Publikováno v: Bioorganicheskaia khimiia. 37(5)

Lynx1 expresses in the central nervous system and plays important role in a regulation of nicotinic acetylcholine receptors. Successful milligram-quantitive expression of ws-Lynx1 was achieved only in the case of its production in the form of cytopla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0730016b71f2a189c58b0412313d2666
https://pubmed.ncbi.nlm.nih.gov/22332355

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[The in vitro production of three-finger neurotoxins from snake venoms with a high abundance of disulfide bonds. Problems and their solutions]

Autor: E N, Liukmanova, M A, Shulepko, Z O, Shenkarev, D A, Dolgikh, M P, Kirpichnikov

Publikováno v: Bioorganicheskaia khimiia. 36(2)

alpha-Neurotoxins from snake venom are highly efficient inhibitors of nicotinic acetylcholine receptors (nAChR). These small proteins that have a beta-structural organization attract much interest as a tool for studies of nACh R and as prototypes for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::24f874e5be4ff336abb213a2357819af
https://pubmed.ncbi.nlm.nih.gov/20531472

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