Zobrazeno 1 - 7
of 7
pro vyhledávání: '"M. A. Sharmini Rajanayagam"'
Autor:
Marjorie Dunlop, M. A. Sharmini Rajanayagam, Michael A. Hill, Timothy V. Murphy, Ian A. Darby, Nour B. Bishara
Publikováno v:
Journal of Cellular Physiology. 193:80-92
Studies have shown diabetes to be associated with alterations in composition of extracellular matrix and that such proteins modulate signal transduction. The present studies examined if non-enzymatic glycation of fibronectin or a mixed matrix prepara
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 375(4)
β-Adrenoceptor-mediated vasorelaxation decreases with age in various vascular beds. The present study investigated the roles of cyclooxygenase (COX) on β-adrenoceptor vasorelaxation by isoprenaline in 8- and 54-week-old rat aortas. The vasorelaxati
Autor:
Michael A. Hill, Simon J. Potocnik, Ian A. Darby, Michael J. Davis, M. A. Sharmini Rajanayagam, Timothy V. Murphy, Nour B. Bishara, Kay Richards
Publikováno v:
Clinical and experimental pharmacologyphysiology. 30(9)
1. An exact understanding of signal transduction pathways within intact and functional arteriolar smooth muscle is made difficult by limited access to the intracellular environment due to the cell membrane. The aim of the present studies was to deter
Autor:
Hong Xin Wang, M. A. Sharmini Rajanayagam, Michael A. Hill, Michael J. Davis, Simon J. Potocnik
Publikováno v:
The American journal of physiology. 277(1)
Local control of neural blood flow is considered to reside in innervation of epineurial and endoneurial arterioles rather than in intrinsic autoregulatory mechanisms. With the use of an isolated vessel preparation and an in vivo approach, the present
Autor:
Toren Finkel, Ronald G. Crystal, M. A. Sharmini Rajanayagam, Stephen E. Epstein, Edward A. Hirschowitz, Raul J. Guzman, Robert L. Harrell, A. Masharn Doanes
Publikováno v:
Circulation. 96(2)
Background Restenosis remains a significant problem after balloon angioplasty. Previous studies have demonstrated that recombinant adenoviruses are efficient vectors for gene transfer to the arterial wall and can be used to inhibit the proliferative
Publikováno v:
European journal of pharmacology. 177(1-2)
The role of alpha 1-, alpha 2- and beta-adrenoceptors in vasoconstrictor responses to sympathetic nerve stimulation was investigated in perfused proximal segments of rat tail artery by using selective blocking drugs. Prazosin (1 nM) markedly reduced
Publikováno v:
British journal of pharmacology. 83(4)
In isolated, perfused proximal segments of Sprague-Dawley rat tail artery, idazoxan (100 nmol l-1) displaced the concentration-response curve to noradrenaline (NA) to the right. The log shift of the NA concentration-response curve was greater at lowe