Zobrazeno 1 - 10
of 96
pro vyhledávání: '"M. A. Pearl"'
Autor:
Federica Schiavoni, Pedro Zuazua-Villar, Theodoros I. Roumeliotis, Graeme Benstead-Hume, Mercedes Pardo, Frances M. G. Pearl, Jyoti S. Choudhary, Jessica A. Downs
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Aneuploidy results in decreased cellular fitness in many species and model systems. However, aneuploidy is commonly found in cancer cells and often correlates with aggressive growth, suggesting that the impact of aneuploidy on cellular fitness is con
Externí odkaz:
https://doaj.org/article/6eaf790b03964eb082453da384012a47
Autor:
Graeme Benstead-Hume, Xiangrong Chen, Suzanna R Hopkins, Karen A Lane, Jessica A Downs, Frances M G Pearl
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 4, p e1006888 (2019)
In response to a need for improved treatments, a number of promising novel targeted cancer therapies are being developed that exploit human synthetic lethal interactions. This is facilitating personalised medicine strategies in cancers where specific
Externí odkaz:
https://doaj.org/article/7ff53ac2ee9f4c0ba91fa3e7ae6c0c3c
Autor:
M. Alexander Pearl
Publikováno v:
Law & Society Review.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b606ea6e4294dc0fef3eb7d78ce872c
https://doi.org/10.1111/lasr.12657
https://doi.org/10.1111/lasr.12657
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 22, p 5762 (2019)
Using pan-cancer data from The Cancer Genome Atlas (TCGA), we investigated how patterns in copy number alterations in cancer cells vary both by tissue type and as a function of genetic alteration. We find that patterns in both chromosomal ploidy and
Externí odkaz:
https://doaj.org/article/7c888ddbc85a42c48f4f6a74c61ae83f
Autor:
Hanadi M. Baeissa, Frances M. G. Pearl
Publikováno v:
Journal of Computational Biology. 27:786-795
Inframe insertion and deletion mutations (indels) are commonly observed in cancer samples accounting for over 1% of all reported mutations. Few somatic inframe indels have been clinically documented as pathogenic and at present there are few tools to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d93c53240924fe3265d1d9ccd7aa1270
https://doi.org/10.1089/cmb.2018.0192
https://doi.org/10.1089/cmb.2018.0192
Autor:
Graeme Benstead-Hume, Sarah K Wooller, Joanna Renaut, Samantha Dias, Lisa Woodbine, Antony M Carr, Frances M G Pearl
Publikováno v:
Bioinformatics Advances. 2
Motivation Protein–protein interaction (PPI) networks have been shown to successfully predict essential proteins. However, such networks are derived generically from experiments on many thousands of different cells. Consequently, conventional PPI n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::374c4d227e52fdfe7b7f274596513eb9
https://doi.org/10.1093/bioadv/vbac084
https://doi.org/10.1093/bioadv/vbac084
Autor:
Michelle Yeo, Kent Ayoungman, Catherine M. L. Pearl, Wathu Wida, Tanya Stogre, Liam Haggarty, Angela Waldie
Publikováno v:
New Directions for Teaching and Learning. 2019:27-41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a3a4c804cc923504b269cd0c385cd0b
https://doi.org/10.1002/tl.20328
https://doi.org/10.1002/tl.20328
Autor:
Sarah K. Wooller, Murat Eravci, Aikaterini Anagnostopoulou, Michael Crossley, Benno Kuropka, György Kemenes, Ildikó Kemenes, Frances M. G. Pearl, Paul R. Benjamin
Applications of key technologies in biomedical research, such as qRT-PCR or LC-MS based proteomics, are generating large biological (-omics) data sets which are useful for the identification and quantification of biomarkers involved in molecular mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46026899d0753574d1bc489b1c85409a
https://doi.org/10.1101/2021.05.03.442491
https://doi.org/10.1101/2021.05.03.442491
Autor:
Gareth Williams, Sarah R. Walker, Simon E. Ward, Charlotte E L Fisher, Yusuf I Ali, Laurence H. Pearl, Xiangrong Chen, Jessica Hudson, S. Mark Roe, Jessica R Booth, Antony W. Oliver, Mohan B. Rajasekaran, Frances M. G. Pearl, Raquel Arribas-Bosacoma
Publikováno v:
eLife, Vol 10 (2021)
Chen, X, Ali, Y I, Fisher, C E L, Arribas-Bosacoma, R, Rajasekaran, M B, Williams, G, Walker, S, Booth, J R, Hudson, J J R, Mark Roe, S, Pearl, L H, Ward, S E, Pearl, F M G & Oliver, A W 2021, ' Uncovering an allosteric mode of action for a selective inhibitor of human bloom syndrome protein ', eLIFE, vol. 10, e65339 . https://doi.org/10.7554/eLife.65339
eLife
Chen, X, Ali, Y I, Fisher, C E L, Arribas-Bosacoma, R, Rajasekaran, M B, Williams, G, Walker, S, Booth, J R, Hudson, J J R, Mark Roe, S, Pearl, L H, Ward, S E, Pearl, F M G & Oliver, A W 2021, ' Uncovering an allosteric mode of action for a selective inhibitor of human bloom syndrome protein ', eLIFE, vol. 10, e65339 . https://doi.org/10.7554/eLife.65339
eLife
BLM (Bloom syndrome protein) is a RECQ-family helicase involved in the dissolution of complex DNA structures and repair intermediates. Synthetic lethality analysis implicates BLM as a promising target in a range of cancers with defects in the DNA dam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b9f5d9bb2c8248b64c99b0f679fee2
https://elifesciences.org/articles/65339
https://elifesciences.org/articles/65339
Autor:
Mohan B. Rajasekaran, Antony W. Oliver, Jessica Hudson, Sarah R. Walker, S. Mark Roe, Xiangrong Chen, Charlotte E L Fisher, Laurence H. Pearl, Jessica R Booth, Yusuf I Ali, Gareth Williams, Frances M. G. Pearl, Simon E. Ward, Raquel Arribas-Bosacoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::170c4da54edfa8cce3e3b29e871abd10
https://doi.org/10.7554/elife.65339.sa2
https://doi.org/10.7554/elife.65339.sa2