Amyloid and Neurodegeneration: Alzheimer's Disease and Retinal Degeneration

Autor: Anitha Suram, Kumar Sambamurti, Chitra Venugopal, M. A. Pappolla, N. H. Greig, K. A. Sharpe, Y. Zhou, D. K. Lahiri, Bärbel Rohrer, Annamalai Prakasam, Javier Pacheco-Quinto

Publikováno v: Handbook of Neurochemistry and Molecular Neurobiology ISBN: 9780387303437
Handbook of Neurochemistry and Molecular Neurobiology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dadb06ba47b1f80ec4edbdb2cb5b134e
https://doi.org/10.1007/978-0-387-30375-8_7

Induction of NADPH cytochrome P450 reductase by the Alzheimer beta-protein. Amyloid as a 'foreign body'

Autor: M A, Pappolla, R A, Omar, Y J, Chyan, J, Ghiso, K, Hsiao, P, Bozner, G, Perry, M A, Smith, F, Cruz-Sanchez

Publikováno v: Journal of neurochemistry. 78(1)

A large body of data suggests that the Alzheimer's amyloid peptide (Abeta) causes degeneration and death of neurons by mechanisms that involve reactive oxygen species. The pathways involved in Abeta-mediated oxidative injury are only partially unders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5981d86914809d5f35cae27bafa0bef5
https://pubmed.ncbi.nlm.nih.gov/11432979

Image analysis microspectroscopy shows that neurons participate in the genesis of a subset of early primitive (diffuse) senile plaques

Autor: M A, Pappolla, R A, Omar, H V, Vinters

Publikováno v: The American journal of pathology. 139(3)

Amyloid is a component of the senile plaques that characterize one of the major neuropathologic changes in patients with Alzheimer's disease (AD). The sequence of events leading to the accumulation of amyloid precursors in senile plaques is unknown.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8bd8b4333d9f84cfc264ea42d47d479c
https://pubmed.ncbi.nlm.nih.gov/1716046

DIRECT SCAVENGING OF CARBONATE RADICALS BY MELATONIN IDENTIFICATION OF A NEW NEUROPROTECTIVE MECHANISM AGAINST A$BT-MEDIATED TOXICITY

Autor: M. A. Pappolla, B. Poeggler, Y. J. Chyan

Publikováno v: Journal of Neuropathology and Experimental Neurology. 58:511

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9935ce2c9f6e72f4949e48e98b4bf875
https://doi.org/10.1097/00005072-199905000-00021

The 'normal' brain. 'Abnormal' ubiquitinilated deposits highlight an age-related protein change

Autor: M A, Pappolla, R, Omar, B, Saran

Publikováno v: The American journal of pathology. 135(4)

Known morphologic changes that characterize "normal" brain senescence are insufficient to explain the widespread, age-related decline of psychomotor functions. We report that the heavily ubiquitinilated deposits can be consistently detected by immuno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::67bc82647366a9d1cfa7a6fe4e5b97d9
https://pubmed.ncbi.nlm.nih.gov/2552809