Converting PROMIS®-29 v2.0 profile data to SF-36 physical and mental component summary scores in patients with cardiovascular disorders

Autor: Gregor Liegl, Felix H. Fischer, Carl N. Martin, Maria Rönnefarth, Annelie Blumrich, Michael Ahmadi, Leif-Hendrik Boldt, Kai-Uwe Eckardt, Matthias Endres, Frank Edelmann, Holger Gerhardt, Ulrike Grittner, Arash Haghikia, Norbert Hübner, Ulf Landmesser, David Leistner, Knut Mai, Jil Kollmus-Heege, Dominik N. Müller, Christian H. Nolte, Sophie K. Piper, Kai M. Schmidt-Ott, Tobias Pischon, Simrit Rattan, Ira Rohrpasser-Napierkowski, Katharina Schönrath, Jeanette Schulz-Menger, Oliver Schweizerhof, Joachim Spranger, Joachim E. Weber, Martin Witzenrath, Sein Schmidt, Matthias Rose

Publikováno v: Health and Quality of Life Outcomes, Vol 22, Iss 1, Pp 1-12 (2024)

Abstract Background Health-related quality of life (HRQL) has become an important outcome parameter in cardiology. The MOS 36-ltem Short-Form Health Survey (SF-36) and the PROMIS-29 are two widely used generic measures providing composite HRQL scores

Externí odkaz: https://doaj.org/article/e16e431aec684125985e3087cdefce6b

Discovery of a non-canonical GRHL1 binding site using deep convolutional and recurrent neural networks

Autor: Sebastian Proft, Janna Leiz, Udo Heinemann, Dominik Seelow, Kai M. Schmidt-Ott, Maria Rutkiewicz

Publikováno v: BMC Genomics, Vol 24, Iss 1, Pp 1-11 (2023)

Abstract Background Transcription factors regulate gene expression by binding to transcription factor binding sites (TFBSs). Most models for predicting TFBSs are based on position weight matrices (PWMs), which require a specific motif to be present i

Externí odkaz: https://doaj.org/article/28fe24eb9a574b1bb3d2d16dfad99c28

Protocol of the Berlin Long-term Observation of Vascular Events (BeLOVE): a prospective cohort study with deep phenotyping and long-term follow up of cardiovascular high-risk patients

Autor: Ulrike Grittner, Ulf Landmesser, Matthias Endres, David M Leistner, Burkert Pieske, Kai-Uwe Eckardt, Joachim Spranger, Jeanette Schulz-Menger, Sophie K Piper, Martin Witzenrath, Geraldine Rauch, Sein Schmidt, Vasan S Ramachandran, Christian H Nolte, Tobias Pischon, Dominik N Müller, Frank Edelmann, Leif-Hendrik Boldt, Norbert Hubner, Kai M Schmidt-Ott, Bob Siegerink, Joachim E Weber, Michael Ahmadi, Holger Gerhardt, Kathrin Haubold, Jil Kollmus-Heege, Knut Mai, Simrit Rattan, Katharina Schönrath, Oliver Schweizerhof

Publikováno v: BMJ Open, Vol 13, Iss 10 (2023)

Introduction The Berlin Long-term Observation of Vascular Events is a prospective cohort study that aims to improve prediction and disease-overarching mechanistic understanding of cardiovascular (CV) disease progression by comprehensively investigati

Externí odkaz: https://doaj.org/article/6928f849c2c5480ebd61b441aa81f6d7

Discordance between estimated and measured changes in plasma volume among patients with acute heart failure

Autor: Jutta S. Swolinsky, Enkhtuvshin Tuvshinbat, David M. Leistner, Frank Edelmann, Fabian Knebel, Niklas P. Nerger, Caroline Lemke, Robert Roehle, Michael Haase, Maria Rosa Costanzo, Geraldine Rauch, Veselin Mitrovic, Edis Gasanin, Daniel Meier, Peter A. McCullough, Kai‐Uwe Eckardt, Bruce A. Molitoris, Kai M. Schmidt‐Ott

Publikováno v: ESC Heart Failure, Vol 9, Iss 1, Pp 66-76 (2022)

Abstract Aims In acute heart failure (AHF), changes of venous haemoglobin (Hb) concentrations, haematocrit (Hct), and estimated plasma volume (ePV) have been proposed as surrogates of decongestion. These estimates are based on the theoretical assumpt

Externí odkaz: https://doaj.org/article/237b51ef4fb24579809c7c33a7f3659f

Shorter versus longer corticosteroid duration and recurrent immune checkpoint inhibitor-associated AKI

Autor: Joe-Elie Salem, Enriqueta Felip, Shuchi Anand, Karolina Benesova, Marlies Ostermann, Ala Abudayyeh, Omar Mamlouk, Umut Selamet, Grace Cherry, Sunandana Chandra, Sandra M Herrmann, Maria Jose Soler, Abhijat Kitchlu, Jamie S Lin, Kerry L Reynolds, Elizabeth M Gaughan, Eva Muñoz-Couselo, Jamie S Hirsch, Pablo Garcia, Meghan E Sise, Thibaud Koessler, Mark Eijgelsheim, Shruti Gupta, Frank B Cortazar, Jason M Prosek, Ilya Glezerman, Shveta S Motwani, Naoka Murakami, Rimda Wanchoo, David I Ortiz-Melo, Arash Rashidi, Ben Sprangers, Vikram Aggarwal, A Bilal Malik, Sebastian Loew, Christopher A Carlos, Pazit Beckerman, Zain Mithani, Chintan V Shah, Amanda D Renaghan, Sophie De Seigneux, Luca Campedel, Daniel Sanghoon Shin, Sunil Rangarajan, Priya Deshpande, Gaia Coppock, Marium Husain, Clara Garcia-Carro, Sheila Bermejo, Nuttha Lumlertgul, Nina Seylanova, Busra Isik, Aydin Kaghazchi, Yuriy Khanin, Sheru K Kansal, Kai M Schmidt-Ott, Raymond K Hsu, Maria C Tio, Harkarandeep Singh, Kenar D Jhaveri, David E Leaf, Corinne Isnard Bagnis, Suraj S Mothi, Weiting Chang, Vipulbhai Sakhiya, Daniel Stalbow, Sylvia Wu, Armando Cennamo, Anne Rigg, Nisha Shaunak, Zoe A Kibbelaar, Harish S Seethapathy, Meghan Lee, Ian A Strohbhen, Ilya G Glezerman, Dwight H Owen, Sharon Mini, Andrey Kisel, Nicole Albert, Katherine Carter, Vicki Donley, Tricia Young, Heather Cigoi, Els Wauters Ben Sprangers, Javier A Pagan, Jonathan J Hogan, Valda Page, Samuel AP Short, Maria Josep Carreras, Sethu M. Madhavan

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)

Background Corticosteroids are the mainstay of treatment for immune checkpoint inhibitor-associated acute kidney injury (ICPi-AKI), but the optimal duration of therapy has not been established. Prolonged use of corticosteroids can cause numerous adve

Externí odkaz: https://doaj.org/article/a6f6e1b57fb14e89bf208b6a482d2a1a