Zobrazeno 1 - 10
of 287
pro vyhledávání: '"M. A. Moseley"'
Autor:
Virginia Byers Kraus, Alexander Reed, Erik J. Soderblom, M. Arthur Moseley, Ming-Feng Hsueh, Mukundun G. Attur, Jonathan Samuels, Steven B. Abramson, Yi-Ju Li
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 6, Iss 1, Pp 100425- (2024)
Objective: To further validate a serum proteomics panel for predicting radiographic (structural) knee OA progression. Design: Serum peptides were targeted by multiple-reaction-monitoring mass spectrometry in the New York University cohort (n =
Externí odkaz:
https://doaj.org/article/004b8865f9564922b46dfd78e1c4383f
Autor:
Charles D. Giamberardino, Wiley A. Schell, Jennifer L. Tenor, Dena L. Toffaletti, Julia R. Palmucci, Choiselle Marius, Jane-Valeriane K. Boua, Quinlyn Soltow, Robert Mansbach, M. Arthur Moseley, J. Will Thompson, Laura G. Dubois, William Hope, John R. Perfect, Karen Joy Shaw
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Cryptococcal Meningitis (CM) is uniformly fatal if not treated, and treatment options are limited. We previously reported on the activity of APX2096, the prodrug of the novel Gwt1 inhibitor APX2039, in a mouse model of CM. Here, we investiga
Externí odkaz:
https://doaj.org/article/12c94fc2bb48423287573f9192ce65ce
Autor:
Siamak MahmoudianDehkordi, Ahmed T. Ahmed, Sudeepa Bhattacharyya, Xianlin Han, Rebecca A. Baillie, Matthias Arnold, Michelle K. Skime, Lisa St. John-Williams, M. Arthur Moseley, J. Will Thompson, Gregory Louie, Patricio Riva-Posse, W. Edward Craighead, William McDonald, Ranga Krishnan, A. John Rush, Mark A. Frye, Boadie W. Dunlop, Richard M. Weinshilboum, Rima Kaddurah-Daouk, The Mood Disorders Precision Medicine Consortium (MDPMC)
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for major depressive disorder (MDD), yet their mechanisms of action are not fully understood and their therapeutic benefit varies among individuals. We used a targe
Externí odkaz:
https://doaj.org/article/9ab1fb8fadf043bab4c692f343ee6618
Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart
Autor:
Jacquelyn M. Walejko, Bridgette A. Christopher, Scott B. Crown, Guo-Fang Zhang, Adrian Pickar-Oliver, Takeshi Yoneshiro, Matthew W. Foster, Stephani Page, Stephan van Vliet, Olga Ilkayeva, Michael J. Muehlbauer, Matthew W. Carson, Joseph T. Brozinick, Craig D. Hammond, Ruth E. Gimeno, M. Arthur Moseley, Shingo Kajimura, Charles A. Gersbach, Christopher B. Newgard, Phillip J. White, Robert W. McGarrah
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Systemic modulation of branched-chain keto acid (BCKA) metabolism alters cardiac health. Here, the authors define the major fates of BCKA in the heart and demonstrate that acute exposure to BCKA levels found in obesity activates cardiac protein synth
Externí odkaz:
https://doaj.org/article/13e6e6480fe7436f81d6416509424af3
Autor:
Matthias Arnold, Kwangsik Nho, Alexandra Kueider-Paisley, Tyler Massaro, Kevin Huynh, Barbara Brauner, Siamak MahmoudianDehkordi, Gregory Louie, M. Arthur Moseley, J. Will Thompson, Lisa St John-Williams, Jessica D. Tenenbaum, Colette Blach, Rui Chang, Roberta D. Brinton, Rebecca Baillie, Xianlin Han, John Q. Trojanowski, Leslie M. Shaw, Ralph Martins, Michael W. Weiner, Eugenia Trushina, Jon B. Toledo, Peter J. Meikle, David A. Bennett, Jan Krumsiek, P. Murali Doraiswamy, Andrew J. Saykin, Rima Kaddurah-Daouk, Gabi Kastenmüller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Sex and the APOE ε4 genotype are important risk factors for late-onset Alzheimer’s disease. In the current study, the authors investigate how sex and APOE ε4 genotype modify the association between Alzheimer’s disease biomarkers and metabolites
Externí odkaz:
https://doaj.org/article/4622f4afa16f4c509372906b7b40a13c
Autor:
E. Keats Shwab, Praveen R. Juvvadi, Greg Waitt, Shareef Shaheen, John Allen, Erik J. Soderblom, Benjamin G. Bobay, Yohannes G. Asfaw, M. Arthur Moseley, William J. Steinbach
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT Protein kinase A (PKA) signaling plays a critical role in the growth and development of all eukaryotic microbes. However, few direct targets have been characterized in any organism. The fungus Aspergillus fumigatus is a leading infectious ca
Externí odkaz:
https://doaj.org/article/3ece9604418c42c0a8b4f8936774ea35
Autor:
E. Keats Shwab, Praveen R. Juvvadi, Shareef K. Shaheen, John Allen, Greg Waitt, Erik J. Soderblom, Yohannes G. Asfaw, M. Arthur Moseley, William J. Steinbach
Publikováno v:
Journal of Fungi, Vol 8, Iss 4, p 354 (2022)
Cellular recycling via autophagy-associated proteins is a key catabolic pathway critical to invasive fungal pathogen growth and virulence in the nutrient-limited host environment. Protein kinase A (PKA) is vital for the growth and virulence of numero
Externí odkaz:
https://doaj.org/article/5d1e3deab50c4838b224a9b4d520e93f
Autor:
John A. Bowden, Alan Heckert, Candice Z. Ulmer, Christina M. Jones, Jeremy P. Koelmel, Laila Abdullah, Linda Ahonen, Yazen Alnouti, Aaron M. Armando, John M. Asara, Takeshi Bamba, John R. Barr, Jonas Bergquist, Christoph H. Borchers, Joost Brandsma, Susanne B. Breitkopf, Tomas Cajka, Amaury Cazenave-Gassiot, Antonio Checa, Michelle A. Cinel, Romain A. Colas, Serge Cremers, Edward A. Dennis, James E. Evans, Alexander Fauland, Oliver Fiehn, Michael S. Gardner, Timothy J. Garrett, Katherine H. Gotlinger, Jun Han, Yingying Huang, Aveline Huipeng Neo, Tuulia Hyötyläinen, Yoshihiro Izumi, Hongfeng Jiang, Houli Jiang, Jiang Jiang, Maureen Kachman, Reiko Kiyonami, Kristaps Klavins, Christian Klose, Harald C. Köfeler, Johan Kolmert, Therese Koal, Grielof Koster, Zsuzsanna Kuklenyik, Irwin J. Kurland, Michael Leadley, Karen Lin, Krishna Rao Maddipati, Danielle McDougall, Peter J. Meikle, Natalie A. Mellett, Cian Monnin, M. Arthur Moseley, Renu Nandakumar, Matej Oresic, Rainey Patterson, David Peake, Jason S. Pierce, Martin Post, Anthony D. Postle, Rebecca Pugh, Yunping Qiu, Oswald Quehenberger, Parsram Ramrup, Jon Rees, Barbara Rembiesa, Denis Reynaud, Mary R. Roth, Susanne Sales, Kai Schuhmann, Michal Laniado Schwartzman, Charles N. Serhan, Andrej Shevchenko, Stephen E. Somerville, Lisa St. John-Williams, Michal A. Surma, Hiroaki Takeda, Rhishikesh Thakare, J. Will Thompson, Federico Torta, Alexander Triebl, Martin Trötzmüller, S. J. Kumari Ubhayasekera, Dajana Vuckovic, Jacquelyn M. Weir, Ruth Welti, Markus R. Wenk, Craig E. Wheelock, Libin Yao, Min Yuan, Xueqing Heather Zhao, Senlin Zhou
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 12, Pp 2275-2288 (2017)
As the lipidomics field continues to advance, self-evaluation within the community is critical. Here, we performed an interlaboratory comparison exercise for lipidomics using Standard Reference Material (SRM) 1950–Metabolites in Frozen Human Plasma
Externí odkaz:
https://doaj.org/article/e757670a32e84af9bc9bad52c975b5dc
Autor:
Thomas W. Burke, Ricardo Henao, Erik Soderblom, Ephraim L. Tsalik, J. Will Thompson, Micah T. McClain, Marshall Nichols, Bradly P. Nicholson, Timothy Veldman, Joseph E. Lucas, M. Arthur Moseley, Ronald B. Turner, Robert Lambkin-Williams, Alfred O. Hero, III, Christopher W. Woods, Geoffrey S. Ginsburg
Publikováno v:
EBioMedicine, Vol 17, Iss C, Pp 172-181 (2017)
Infection of respiratory mucosa with viral pathogens triggers complex immunologic events in the affected host. We sought to characterize this response through proteomic analysis of nasopharyngeal lavage in human subjects experimentally challenged wit
Externí odkaz:
https://doaj.org/article/4680ef2cc41047b0b38e84b878e5e24d
Publikováno v:
Frontiers in Marine Science, Vol 6 (2019)
Growth, molting, and hardening cuticle are intertwined processes for arthropods and share common protein systems to execute these functions. For barnacles, these processes are also tied to adhesion, which is vital to their survival and under great se
Externí odkaz:
https://doaj.org/article/edc374d92b06486e8d11c6a038abcce4