Zobrazeno 1 - 10
of 1 296
pro vyhledávání: '"M. A. Ikram"'
Autor:
Ariadne Bosman, W. Nadia H. Koek, Natalia Campos-Obando, Bram C. J. van der Eerden, M. A. Ikram, André G. Uitterlinden, Johannes P. T. M. van Leeuwen, M. C. Zillikens
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Sex differences in serum phosphate and calcium have been reported but the exact nature and underlying regulatory mechanisms remain unclear. We aimed to compare calcium and phosphate concentrations between sexes, and explore potential covaria
Externí odkaz:
https://doaj.org/article/73cdc742487d446cad10ed487b8298e8
Autor:
L. J. Dommershuijsen, A. Van der Heide, E. M. Van den Berg, J. A. Labrecque, M. K. Ikram, M. A. Ikram, B. R. Bloem, R. C. Helmich, S. K. L. Darweesh
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-9 (2021)
Abstract The COVID-19 pandemic has introduced a myriad of challenges to the social life and care of people with Parkinson’s disease (PD), which could potentially worsen mental health problems. We used baseline data of the PRIME-NL study (N = 844) t
Externí odkaz:
https://doaj.org/article/63d9fd9e102843a7879d6cc13c5a1bd2
Autor:
W. Huizinga, D. H. J. Poot, E. J. Vinke, F. Wenzel, E. E. Bron, N. Toussaint, C. Ledig, H. Vrooman, M. A. Ikram, W. J. Niessen, M. W. Vernooij, S. Klein
Publikováno v:
Frontiers in Big Data, Vol 4 (2021)
For the segmentation of magnetic resonance brain images into anatomical regions, numerous fully automated methods have been proposed and compared to reference segmentations obtained manually. However, systematic differences might exist between the re
Externí odkaz:
https://doaj.org/article/9c97130c845c4c538b89fdc9bec714a0
Autor:
Yash Patel, Jean Shin, Eeva Sliz, Ariana Tang, Aniket Mishra, Rui Xia, Edith Hofer, Hema Sekhar Reddy Rajula, Ruiqi Wang, Frauke Beyer, Katrin Horn, Max Riedl, Jing Yu, Henry Völzke, Robin Bülow, Uwe Völker, Stefan Frenzel, Katharina Wittfeld, Sandra Van der Auwera, Thomas H. Mosley, Vincent Bouteloup, Jean-Charles Lambert, Geneviève Chêne, Carole Dufouil, Christophe Tzourio, Jean-François Mangin, Rebecca F. Gottesman, Myriam Fornage, Reinhold Schmidt, Qiong Yang, Veronica Witte, Markus Scholz, Markus Loeffler, Gennady V. Roshchupkin, M. Arfan Ikram, Hans J. Grabe, Sudha Seshadri, Stephanie Debette, Tomas Paus, Zdenka Pausova
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract White matter hyperintensities index structural abnormalities in the cerebral white matter, including axonal damage. The latter may promote atrophy of the cerebral cortex, a key feature of dementia. Here, we report a study of 51,065 individua
Externí odkaz:
https://doaj.org/article/bf9509bdebd5484ea27088d73ad6ccb8
Autor:
Rima Mustafa, Michelle M. J. Mens, Arno van Hilten, Jian Huang, Gennady Roshchupkin, Tianxiao Huan, Linda Broer, Joyce B. J. van Meurs, Paul Elliott, Daniel Levy, M. Arfan Ikram, Marina Evangelou, Abbas Dehghan, Mohsen Ghanbari
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-26 (2024)
Abstract Background MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. Perturbations in plasma miRNA levels are known to impact disease risk and have potential as disease biomarkers. Exploring the genet
Externí odkaz:
https://doaj.org/article/625b253401c940869bcf67b3973bd481
Autor:
Shahzad Ahmad, Mohammad Aslam Imtiaz, Aniket Mishra, Ruiqi Wang, Marisol Herrera-Rivero, Joshua C. Bis, Myriam Fornage, Gennady Roshchupkin, Edith Hofer, Mark Logue, W. T. Longstreth, Rui Xia, Vincent Bouteloup, Thomas Mosley, Lenore J. Launer, Michael Khalil, Jens Kuhle, Robert A. Rissman, Genevieve Chene, Carole Dufouil, Luc Djoussé, Michael J. Lyons, Kenneth J. Mukamal, William S. Kremen, Carol E. Franz, Reinhold Schmidt, Stephanie Debette, Monique M. B. Breteler, Klaus Berger, Qiong Yang, Sudha Seshadri, N. Ahmad Aziz, Mohsen Ghanbari, M. Arfan Ikram
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Neurofilament light chain (NfL) levels in circulation have been established as a sensitive biomarker of neuro-axonal damage across a range of neurodegenerative disorders. Elucidation of the genetic architecture of blood NfL levels could prov
Externí odkaz:
https://doaj.org/article/14e2c47872a446f281d0e204198d3b52
Autor:
Ilse vom Hofe, Bruno H. Stricker, Meike W. Vernooij, M. Kamran Ikram, M. Arfan Ikram, Frank J. Wolters
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract Background Benzodiazepine use is common, particularly in older adults. Benzodiazepines have well-established acute adverse effects on cognition, but long-term effects on neurodegeneration and dementia risk remain uncertain. Methods We includ
Externí odkaz:
https://doaj.org/article/3e425f59612e433990f8ac8341df49a8
Autor:
Yu Shuai, Xiaofang Zhang, Birgit D. A. Lavrijssen, M. Arfan Ikram, Rikje Ruiter, Bruno Stricker, Mohsen Ghanbari
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-4 (2024)
Abstract MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional regulation of gene expression. Mounting evidence underscores the dysregulation of miRNAs to be associated with cancer development and progression by acting as tumo
Externí odkaz:
https://doaj.org/article/13e54d973a7343fda79c92c68e3c364d
Autor:
Arno van Hilten, Jeroen van Rooij, BIOS consortium, M. Arfan Ikram, Wiro J. Niessen, Joyce. B. J. van Meurs, Gennady V. Roshchupkin
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract Integrating multi-omics data into predictive models has the potential to enhance accuracy, which is essential for precision medicine. In this study, we developed interpretable predictive models for multi-omics data by employing neural networ
Externí odkaz:
https://doaj.org/article/296197b7ce774b4fbd8e3012971c3fd4
Autor:
William J. Young, Peter J. van der Most, Traci M. Bartz, Maxime M. Bos, Ginevra Biino, ThuyVy Duong, Luisa Foco, Jesus T. Lominchar, Martina Müller‐Nurasyid, Giuseppe Giovanni Nardone, Alessandro Pecori, Julia Ramirez, Linda Repetto, Katharina Schramm, Xia Shen, Stefan van Duijvenboden, Diana van Heemst, Stefan Weiss, Jie Yao, Jan‐Walter Benjamins, Alvaro Alonso, Beatrice Spedicati, Mary L. Biggs, Jennifer A. Brody, Marcus Dörr, Christian Fuchsberger, Martin Gögele, Xiuqing Guo, M. Arfan Ikram, J. Wouter Jukema, Stefan Kääb, Jørgen K. Kanters, Henry J. Lin, Allan Linneberg, Matthias Nauck, Ilja M. Nolte, Giulia Pianigiani, Aurora Santin, Elsayed Z. Soliman, Paola Tesolin, Simona Vaccargiu, Melanie Waldenberger, Pim van der Harst, Niek Verweij, Dan E. Arking, Maria Pina Concas, Alessandro De Grandi, Giorgia Girotto, Niels Grarup, Maryam Kavousi, Dennis O. Mook‐Kanamori, Pau Navarro, Michele Orini, Sandosh Padmanabhan, Cristian Pattaro, Annette Peters, Mario Pirastu, Peter P. Pramstaller, Susan R. Heckbert, Mortiz Sinner, Harold Snieder, Uwe Völker, James F. Wilson, W. James Gauderman, Pier D. Lambiase, Nona Sotoodehnia, Andrew Tinker, Helen R. Warren, Raymond Noordam, Patricia B. Munroe
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 17 (2024)
Background Ventricular repolarization time (ECG QT and JT intervals) is associated with malignant arrhythmia. Genome‐wide association studies have identified 230 independent loci for QT and JT; however, 50% of their heritability remains unexplained
Externí odkaz:
https://doaj.org/article/d9db835045cc4f1b993097b3854693a3