Zobrazeno 1 - 10
of 571
pro vyhledávání: '"M. A. Hashimi"'
Autor:
Ainan Geng, Laura Ganser, Rohit Roy, Honglue Shi, Supriya Pratihar, David A. Case, Hashim M. Al-Hashimi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Sparse and short-lived excited RNA conformational states are essential players in cell physiology, disease, and therapeutic development, yet determining their 3D structures remains challenging. Combining mutagenesis, NMR spectroscopy, and co
Externí odkaz:
https://doaj.org/article/19d0e5c055614e97812f937259ec0244
Autor:
Lakshmi Bhai, Justin K. Thomas, Daniel W. Conroy, Yu Xu, Hashim M. Al-Hashimi, Christopher P. Jaroniec
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Numerous biological processes and mechanisms depend on details of base pairing and hydrogen bonding in DNA. Hydrogen bonds are challenging to quantify by X-ray crystallography and cryo-EM due to difficulty of visualizing hydrogen atom locations but c
Externí odkaz:
https://doaj.org/article/3be8326e3076417e96f7d844849990c1
Publikováno v:
Magnetic Resonance, Vol 2, Pp 715-731 (2021)
In duplex DNA, Watson–Crick A–T and G–C base pairs (bp's) exist in dynamic equilibrium with an alternative Hoogsteen conformation, which is low in abundance and short-lived. Measuring how the Hoogsteen dynamics varies across different DNA seque
Externí odkaz:
https://doaj.org/article/6b09d66ee4ab47f7b95be1ab28c435a1
Autor:
Bei Liu, Honglue Shi, Atul Rangadurai, Felix Nussbaumer, Chia-Chieh Chu, Kevin Andreas Erharter, David A. Case, Christoph Kreutz, Hashim M. Al-Hashimi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
m6A RNA post-transcriptional modification changes RNA hybridization kinetics. Here the authors show that the methylamino group can adopt syn-conformation pairing with uridine with a mismatch-like conformation in RNA duplex. They also develop a quanti
Externí odkaz:
https://doaj.org/article/82625506d090481bad2beca7aff5481e
Autor:
Honglue Shi, Atul Rangadurai, Hala Abou Assi, Rohit Roy, David A. Case, Daniel Herschlag, Joseph D. Yesselman, Hashim M. Al-Hashimi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Determining dynamic ensembles of biomolecules is still challenging. Here the authors present an approach for rapid RNA ensemble determination that combines RNA structure prediction tools and NMR residual dipolar coupling data and use it to determine
Externí odkaz:
https://doaj.org/article/6aa8fe55c63a47b68b968427d832dae8
Autor:
Abdulrahman M. Al-hashimi
Publikováno v:
Biosciences Biotechnology Research Asia. 20:13-28
Rice (Oryza sativa L.) is the most important staple crop. Rice is a source of essential vitamins such as vitamin C and B6, carbohydrates and other nutrients such as selenium and phosphorous. About 90% of world’s rice are cultivated in Asia and Afri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::934165737c0a4028c1db757825b03b20
https://doi.org/10.13005/bbra/3064
https://doi.org/10.13005/bbra/3064
Autor:
Laura R. Ganser, Chia-Chieh Chu, Hal P. Bogerd, Megan L. Kelly, Bryan R. Cullen, Hashim M. Al-Hashimi
Publikováno v:
Cell Reports, Vol 30, Iss 8, Pp 2472-2480.e4 (2020)
Summary: Low-abundance short-lived non-native conformations referred to as excited states (ESs) are increasingly observed in vitro and implicated in the folding and biological activities of regulatory RNAs. We developed an approach for assessing the
Externí odkaz:
https://doaj.org/article/3656ad3759aa4bcfa8bd4cb78e3694e8
Autor:
Bei Liu, Dawn K. Merriman, Seung H. Choi, Maria A. Schumacher, Raphael Plangger, Christoph Kreutz, Stacy M. Horner, Kate D. Meyer, Hashim M. Al-Hashimi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
N 6-Methyladenosine (m6A) is a post-transcriptional RNA modification that modulates RNA structure through a destabilization of m6A base pairing. Here the authors use NMR and UV melting experiments and show that m6A can also stabilize m6A–U base pai
Externí odkaz:
https://doaj.org/article/372622a59f9c424c8a4a6aac13ebbfc3
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
DNA is found in a dynamic equilibrium between standard Watson-Crick (WC) base pairs and non-standard Hoogsteen (HG) base pairs. Here the authors describe the influence of echinomycin and actinomycin D ligands binding on the HG-WC base pair dynamics i
Externí odkaz:
https://doaj.org/article/b13b41ea233f4bdb8b17d86942bc33d6
Autor:
Brant Gracia, Hashim M. Al-Hashimi, Namita Bisaria, Rhiju Das, Daniel Herschlag, Rick Russell
Publikováno v:
Cell Reports, Vol 22, Iss 12, Pp 3240-3250 (2018)
Summary: Large-scale, cooperative rearrangements underlie the functions of RNA in RNA-protein machines and gene regulation. To understand how such rearrangements are orchestrated, we used high-throughput chemical footprinting to dissect a seemingly c
Externí odkaz:
https://doaj.org/article/18138734a5714f62b4f12fef9807c357