Disease‐specific accumulation of mutant ubiquitin as a marker for proteasomal dysfunction in the brain

Autor: Wouter Kamphorst, Fred W. van Leeuwen, Marian C. Verhage, Femke M.S. de Vrij, Rob A.I. de Vos, Elly M. Hol, David F. Fischer, M. A. F. Sonnemans, Barbara Hobo, Ernst N.H. Jansen Steur, Mohamed Zouambia, Jacqueline A. Sluijs, Renske van Dijk, Evelien A. Proper

Publikováno v: The FASEB Journal. 17:2014-2024

Molecular misreading of the ubiquitin-B (UBB) gene results in a dinucleotide deletion in UBB mRNA. The resulting mutant protein, UBB+1, accumulates in the neuropathological hallmarks of Alzheimer disease. In vitro, UBB+1 inhibits proteasomal proteoly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1887374fc95528db9864b315075ea7
https://doi.org/10.1096/fj.03-0205com

Molecular misreading in non‐neuronal cells

Autor: Fred W. van Leeuwen, Rob W. H. Hermanussen, M. A. F. Sonnemans, D.A.P. Evans, Kum-Fai Chooi, Ewoud Moraal, David Murphy, David F. Fischer, Elly M. Hol, J. Peter H. Burbach

Publikováno v: The FASEB Journal. 14:1595-1602

+1 Frame-shifted proteins such as amyloid precursor protein+1 and ubiquitin-B+1 have been identified in the neuropathological hallmarks of Alzheimer’s disease. These frameshifts are caused by dinucleotide deletions in GAGAG motifs of messenger RNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::226322a3015f04563cbdf5188ca0978b
https://doi.org/10.1096/fj.99-0825com

Specific expression of secretogranin II in magnocellular vasopressin neurons of the rat supraoptic and paraventricular nucleus in response to osmotic stimulation

Autor: M. A. F. Sonnemans, C.H Dotman, F.W. van Leeuwen, C.W Ang, Reiner Fischer-Colbrie, Hans Winkler

Publikováno v: Brain research, 765(1), 13-20. Elsevier

As secretogranin II is considered to be a marker for the regulated secretory pathway, its distribution in the hypothalamo-neurohypophyseal system of salt-loaded Wistar rats was studied in detail by immunocytochemistry. Although after an osmotic chall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9895961d992580e1ce6c6abff31ae32
https://doi.org/10.1016/s0006-8993(97)00462-9

Quantitative estimation of estrogen and androgen receptor-immunoreactive cells in the forebrain of neonatally estrogen-deprived male rats

Autor: C.W. Pool, F.W. van Leeuwen, M. A. F. Sonnemans, Julie Bakker, A. K. Slob

Publikováno v: Neuroscience, 77(3), 911-919. Elsevier Ltd.

Using quantitative immunocytochemical procedures, the total number of estrogen and androgen receptors was estimated in a large number of hypothalamic and limbic nuclei of male rats, in which brain estrogen formation was inhibited neonatally by treatm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfcbd8880ca8d98ca67aec420e99e6bc
https://doi.org/10.1016/s0306-4522(96)00423-x

Rat oxytocin receptor in brain, pituitary, mammary gland, and uterus: partial sequence and immunocytochemical localization

Autor: J. P. H. Burbach, J. G. Verbalis, F.W. van Leeuwen, R. A. N. Adan, M. A. F. Sonnemans, Madeleine R. Brouns, G. Hoffman

Publikováno v: Endocrinology, 136(9), 4022-4028. The Endocrine Society
Adan, R A, Van Leeuwen, F W, Sonnemans, M A, Brouns, M, Hoffman, G, Verbalis, J G & Burbach, J P 1995, ' Rat oxytocin receptor in brain, pituitary, mammary gland, and uterus : partial sequence and immunocytochemical localization ', Endocrinology, vol. 136, no. 9, pp. 4022-4028 . https://doi.org/10.1210/endo.136.9.7649111

Partial complementary DNAs of an oxytocin (OT) receptor were cloned from rat brain and uterus. The complementary DNAs encoded for the same amino acid sequence, which showed a high degree of homology with the human and porcine uterine OT receptors, ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::168dc470b332a5d8f0368427f919c9e9
https://doi.org/10.1210/endo.136.9.7649111