Výsledky vyhledávání - "M. A. Dodokhova"

Comparative analysis of morphological and biochemical changes after a single intragastric administration of hybrid organotin compounds

Autor: M. A. Dodokhova, O. V. Voronova, I. M. Kotieva, A. V. Safronenko, S. V. Shlyk, N. V. Drobotya, M. A. Akimenko, D. B. Shpakovsky, E. R. Milaeva

Publikováno v: The Siberian Journal of Clinical and Experimental Medicine. 38:167-174

Introduction. Organotin compounds are promising candidates for antitumor drugs. Identification of pathogenetic features of the general toxic effect of hybrid organotin compounds during the period of the greatest severity of the intoxication clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245b5bd6fb5d3ed50dd195aa2cc2d92f
https://doi.org/10.29001/2073-8552-2023-38-1-167-174

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Analysis of changes in the serotonin inactivation coefficient in brain structures with simultaneous modeling of chronic neurogenic pain and malignant neoplasia

Autor: I. M. Kotieva, E. M. Frantsiyants, S. V. Shlyk, N. V. Drobotya, M. V. Gulyan, M. A. Dodokhova

Publikováno v: The Siberian Journal of Clinical and Experimental Medicine. 38:133-139

Introduction. Chronic pain syndrome in the development of malignant neoplasms has a complex polyethological character. The study of the pathogenetic mechanisms of pain during the growth of the transplanted tumor in the experiment can open up broad pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e37338628964cb88d9dec0a9c721a48
https://doi.org/10.29001/2073-8552-2023-38-1-133-139

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Microtubules as a target of antitumor drugs

Autor: M. A. Dodokhova, I. M. Kotieva, A. V. Safronenko, S. V. Shlyk, N. V. Drobotya, D. B. Shpakovsky

Publikováno v: South Russian Journal of Therapeutic Practice. 3:25-31

The search for new antitumor and antimetastatic therapy targets is a priority task for interdisciplinary research in medical chemistry, experimental pharmacology and pathological physiology. One of the promising scopes of research in this direction i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e336a8961f13c8330259c56ad4a011a
https://doi.org/10.21886/2712-8156-2022-3-3-25-31

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ASSESSMENT OF CARDIOTOXIC SIDE EFFECTS IN THE ADMINISTRATION OF ORGANOTIN COMPOUNDS AT THE PRECLINICAL STAGE OF THE STUDY

Autor: M. A. Dodokhova, A. V. Safronenko, I. M. Kotieva, M. S. Alkhuseyn-Kulyaginova, E. R. Milaeva, D. B. Shpakovsky, Yu. M. Makarenko, A. Yu. Terekhov, E. O. Sergeeva

Publikováno v: Crimea Journal of Experimental and Clinical Medicine. 11:11-18

The most important task of preclinical research of promising candidates for antitumor drugs is to assess the safety of their use. The study of the cardiotoxicity of organotin compounds (OOS) dimethyltin bis (3,5-di-tert-butyl-4-hydroxy- phenylthiolat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bedeac4cab47707a83b0ef63147e5c82
https://doi.org/10.37279/2224-6444-2021-11-2-11-18

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Study of acute oral toxicity of organotin compounds containing a 2,6-di-tert-butylphenol fragment

Autor: V. G. Trepel, A. V. Safronenko, Elena R. Milaeva, M. A. Dodokhova, Ekaterina Fedorovna Komarova, I. M. Kotieva, D. B. Shpakovskiy, M. S. Alkhuseyn-Kulyaginova

Publikováno v: Ural Medical Journal. 20:73-77

The aim of the study was to evaluate the safety of the use of organotin compounds containing a fragment of 2,6-di-tert-butylphenol as pharmaceutical substances when administered intragastrically to Wistar outbred rats (females). Material and methods.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6abfbf5678f2152d42541d099a1c0082
https://doi.org/10.52420/2071-5943-2021-20-3-73-77

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Hybrid organotin compounds — modulators of apoptotic processes in the liver when administered once and repeatedly to Wistar rats

Autor: D. B. Shpakovskiy, Elena R. Milaeva, V. G. Trepel, M. A. Dodokhova, M. S. Alkhuseyn–Kulyaginova, А. V. Safronenko, I. M. Kotieva

Publikováno v: Ural Medical Journal. 20:18-23

Introduction. The aim of the study was to evaluate the effect of hybrid organotin compounds bis(3,5–di– tert–butyl–4–hydroxyphenylthiolate) dimethylol (Me3) and ((3,5–di–tert–butyl–4–hydroxyphenylthiolate) triphenylolol (Me5) on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::347e0097d5893fd5e885e4f8235766da
https://doi.org/10.52420/2071-5943-2021-20-4-18-23

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Mechanisms of the Cytotoxic Action of Organotin Compounds

Autor: Elena R. Milaeva, I. M. Kotieva, M. A. Dodokhova, D.B. Shpakovsky, T.A. Antonenko, E. V. Gantsgorn, Ekaterina Fedorovna Komarova, M. S. Alkhuseyn-Kulyaginova, A. V. Safronenko

Publikováno v: Journal Biomed. 17:88-99

This review analyzed the literature data on the in vitro preclinical study of the cytotoxic properties of organotin compounds, as well as the main mechanisms of their action. The latter consist in interacting with SH groups of proteins, initiating ox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f4f3b4764fd7070d420f3e6d3ef2035
https://doi.org/10.33647/2074-5982-17-2-88-99

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