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Carbamazepine Co-crystallization with Pyridine Carboxamides: Rationalization by Complementary Phase Diagrams and Crystal Energy Landscapes

Autor: Joop H. ter Horst, Sarah L. Price, M. A. Deij, Jaroslaw Mazurek, Matthew Habgood

Publikováno v: Crystal Growth & Design. 10:903-912

Isonicotinamide (INA) co-crystallizes with carbamazepine (CBZ), as do nicotinamide (NA) and benzamide. The structure of CBZ−INA form II is solved from powder and is shown to be isostructural with CBZ−NA. However picolinamide (PA), despite its sim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9915a3e8eaa114fc096670127167e68a
https://doi.org/10.1021/cg901230b

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Discovering New Co-Crystals

Autor: Peter W. Cains, M. A. Deij, J.H. ter Horst

Publikováno v: Crystal Growth & Design. 9:1531-1537

A new and systematic method for co-crystal screening has been developed, based on improvements in the understanding of the thermodynamic factors that influence co-crystal formation. This method works from the premise that pure component solubilities

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67d9dba4277134850e0d727dd6b0edee
https://doi.org/10.1021/cg801200h

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Polymorph Formation Studied by 3D Nucleation Simulations. Application to a Yellow Isoxazolone Dye, Paracetamol, and l-Glutamic Acid

Autor: Joop H. ter Horst, Peter J. Jansens, Elias Vlieg, M. A. Deij, H. Meekes

Publikováno v: Journal of Physical Chemistry B: Condensed Matter, Materials, Surfaces, Interfaces and Biophysical, 111, 7, pp. 1523-1530
Journal of Physical Chemistry B: Condensed Matter, Materials, Surfaces, Interfaces and Biophysical, 111, 1523-1530

Knowledge of the nucleation and growth behavior of polymorphs is vital in a variety of industrial applications. With the aid of the growth probability method the nucleus size is obtained as a function of the driving force for crystallization by simul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62ffde516a6e5ce00735c2046bc053f
https://doi.org/10.1021/jp066509j

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Experimental and computational morphology of three polymorphs of the free base of venlafaxine: a comparison of morphology prediction methods

Autor: H. Meekes, J.T.H. van Eupen, E. Vlieg, P. Verwer, M. A. Deij, P. Bennema

Publikováno v: International Journal of Pharmaceutics, 353, 1-2, pp. 113-123
International Journal of Pharmaceutics, 353, 113-123

In this paper the experimental and the computational studies of the morphology of three polymorphs of the free base of Venlafaxine (( N , N -dimethyl)-2-(1-hydroxy cyclohex-1-yl)-2-(4-methoxyphenyl) ethylamine) are reported. The morphology of all pol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5dcd11ec5e574d76daf13c98ba4b7f
https://hdl.handle.net/2066/70304

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Polymorphism and migratory chiral resulotion of the free base of venlafaxine. A remarkable topotactical solid state transition from a racemate to a racemic conglomerate

Autor: W. W. J. Elffrink, P. Bennema, Elias Vlieg, Rolf Keltjens, E.R.H. van Eck, Arno P. M. Kentgens, R. de Gelder, M. A. Deij, Jan M. M. Smits, J. Th. H. van Eupen, H. Meekes

Publikováno v: Crystal Growth & Design, 8, 71-79
Crystal Growth & Design, 8, 1, pp. 71-79

The unique behavior of the active pharmaceutical ingredient Venlafaxine free base, used as an antidepressant, with respect to polymorphism and chiral resolution is reported. Using several complementary techniques, three crystal structures of Venlafax

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc527abcd37ffe0c10dc0aedf67003a4
http://hdl.handle.net/2066/72059

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