Zobrazeno 1 - 10
of 187
pro vyhledávání: '"M. A. Burger"'
Autor:
Jasper E. Neggers, Brenton R. Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A. Skipper, Annan Yang, Radha L. Kalekar, John M. Krill-Burger, Neekesh V. Dharia, Guillaume Kugener, Jérémie Kalfon, Chen Yuan, Nancy Dumont, Alfredo Gonzalez, Mai Abdusamad, Yvonne Y. Li, Liam F. Spurr, Westley W. Wu, Adam D. Durbin, Brian M. Wolpin, Federica Piccioni, David E. Root, Jesse S. Boehm, Andrew D. Cherniack, Aviad Tsherniak, Andrew L. Hong, William C. Hahn, Kimberly Stegmaier, Todd R. Golub, Francisca Vazquez, Andrew J. Aguirre
Publikováno v:
Cell Reports, Vol 36, Iss 2, Pp 109367- (2021)
Externí odkaz:
https://doaj.org/article/ac506d36e0fc45f58afd5108c6469b14
Autor:
Zuzana Tothova, Anne-Laure Valton, Rebecca A. Gorelov, Mounica Vallurupalli, John M. Krill-Burger, Amie Holmes, Catherine C. Landers, J. Erika Haydu, Edyta Malolepsza, Christina Hartigan, Melanie Donahue, Katerina D. Popova, Sebastian Koochaki, Sergey V. Venev, Jeanne Rivera, Edwin Chen, Kasper Lage, Monica Schenone, Alan D. D’Andrea, Steven A. Carr, Elizabeth A. Morgan, Job Dekker, Benjamin L. Ebert
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
The cohesin complex plays an essential role in chromosome maintenance and transcriptional regulation. Recurrent somatic mutations in the cohesin complex are frequent genetic drivers in cancer, including myelodysplastic syndromes (MDS) and acute myelo
Externí odkaz:
https://doaj.org/article/04d99d4ec50c41c1a8bc57f790a16758
Autor:
Jasper E. Neggers, Brenton R. Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A. Skipper, Annan Yang, Radha L. Kalekar, John M. Krill-Burger, Neekesh V. Dharia, Guillaume Kugener, Jérémie Kalfon, Chen Yuan, Nancy Dumont, Alfredo Gonzalez, Mai Abdusamad, Yvonne Y. Li, Liam F. Spurr, Westley W. Wu, Adam D. Durbin, Brian M. Wolpin, Federica Piccioni, David E. Root, Jesse S. Boehm, Andrew D. Cherniack, Aviad Tsherniak, Andrew L. Hong, William C. Hahn, Kimberly Stegmaier, Todd R. Golub, Francisca Vazquez, Andrew J. Aguirre
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108493- (2020)
Summary: Few therapies target the loss of tumor suppressor genes in cancer. We examine CRISPR-SpCas9 and RNA-interference loss-of-function screens to identify new therapeutic targets associated with genomic loss of tumor suppressor genes. The endosom
Externí odkaz:
https://doaj.org/article/8d45f5f857914e55852e4f26974a4071
Autor:
James M. McFarland, Zandra V. Ho, Guillaume Kugener, Joshua M. Dempster, Phillip G. Montgomery, Jordan G. Bryan, John M. Krill-Burger, Thomas M. Green, Francisca Vazquez, Jesse S. Boehm, Todd R. Golub, William C. Hahn, David E. Root, Aviad Tsherniak
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Integrated analyses of multiple large-scale screenings can be complicated by batch effects and technical artefacts. McFarland et al. introduce DEMETER2, a hierarchical model coupled with model-based normalization, which allows the assessment of diffe
Externí odkaz:
https://doaj.org/article/d0eb361d0bb14b90ba18bfe3b6bb1fd5
Autor:
Elaine M. Oberlick, Matthew G. Rees, Brinton Seashore-Ludlow, Francisca Vazquez, Geoffrey M. Nelson, Neekesh V. Dharia, Barbara A. Weir, Aviad Tsherniak, Mahmoud Ghandi, John M. Krill-Burger, Robin M. Meyers, Xiaofeng Wang, Phil Montgomery, David E. Root, Jake M. Bieber, Sandi Radko, Jaime H. Cheah, C. Suk-Yee Hon, Alykhan F. Shamji, Paul A. Clemons, Peter J. Park, Michael A. Dyer, Todd R. Golub, Kimberly Stegmaier, William C. Hahn, Elizabeth A. Stewart, Stuart L. Schreiber, Charles W.M. Roberts
Publikováno v:
Cell Reports, Vol 28, Iss 9, Pp 2331-2344.e8 (2019)
Summary: Cancer is often seen as a disease of mutations and chromosomal abnormalities. However, some cancers, including pediatric rhabdoid tumors (RTs), lack recurrent alterations targetable by current drugs and need alternative, informed therapeutic
Externí odkaz:
https://doaj.org/article/92a087e67b0f487ba84b47b60011a6bf
Autor:
D. R. Rossato, H. Z. Rosa, J. L. O. Rosa, L. H. Milanesi, V. G. Metz, L. F. D’Àvila, M. E. Burger
Publikováno v:
Molecular Neurobiology. 59:5564-5573
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d42b52f3a722f20301a712cb8591fe5
https://doi.org/10.1007/s12035-022-02927-y
https://doi.org/10.1007/s12035-022-02927-y
Autor:
Daniel P. Bondeson, Brenton R. Paolella, Adhana Asfaw, Michael V. Rothberg, Thomas A. Skipper, Carly Langan, Gabriel Mesa, Alfredo Gonzalez, Lauren E. Surface, Kentaro Ito, Mariya Kazachkova, William N. Colgan, Allison Warren, Joshua M. Dempster, John M. Krill-Burger, Maria Ericsson, Andrew A. Tang, Iris Fung, Emily S. Chambers, Mai Abdusamad, Nancy Dumont, John G. Doench, Federica Piccioni, David E. Root, Jesse Boehm, William C. Hahn, Michael Mannstadt, James M. McFarland, Francisca Vazquez, Todd R. Golub
Publikováno v:
Nature Cancer. 3:681-695
Despite advances in precision medicine, the clinical prospects for patients with ovarian and uterine cancers have not substantially improved. Here, we analyzed genome-scale CRISPR-Cas9 loss-of-function screens across 851 human cancer cell lines and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b13e208ef750cd5c03e21c08b68dab3
https://doi.org/10.1038/s43018-022-00360-7
https://doi.org/10.1038/s43018-022-00360-7
Autor:
Lisa D Cervia, Tsukasa Shibue, Benjamin Gaeta, Ashir A Borah, Lisa Leung, Naomi Li, Nancy Dumont, Alfredo Gonzalez, Nolan Bick, Mariya Kazachkova, Joshua M Dempster, John M Krill-Burger, Federica Piccioni, Namrata D Udeshi, Meagan E Olive, Steven A Carr, David E Root, James M McFarland, Francisca Vazquez, William C Hahn
Publikováno v:
Cancer Research. 82:P3-09
Targeting of mutated oncogenes has led to the identification of new targeted therapies. However, druggable oncogenes do not occur in most cancers. Systematic identification of signaling pathways required for the fitness of cancer cells will facilitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::836287162264eb635377806800a676c7
https://doi.org/10.1158/1538-7445.sabcs21-p3-09-01
https://doi.org/10.1158/1538-7445.sabcs21-p3-09-01
Autor:
Charles W.M. Roberts, William C. Hahn, Loren D. Walensky, Kimberly Stegmaier, Peter J. Park, Prafulla C. Gokhale, Aviad Tsherniak, John M. Krill-Burger, April Cook, Katherine H. Walsh, Justin H. Hwang, Hong L. Tiv, Matthew G. Rees, Elaine M. Oberlick, Guillaume Kugener, Gregory H. Bird, Franziska Wachter, Ann M. Morgan, Minh-Tam Pham, Francisca Vazquez, Su Wang, Neekesh V. Dharia, Andrew L. Hong, Xiaofeng Wang, Andrew O. Giacomelli, Melinda R. Song, Taylor E. Arnoff, Thomas P. Howard
Malignant rhabdoid tumors (MRT) are highly aggressive pediatric cancers that respond poorly to current therapies. In this study, we screened several MRT cell lines with large-scale RNAi, CRISPR-Cas9, and small-molecule libraries to identify potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5e63a84640452290fb3a73f322a7c2
https://doi.org/10.1158/0008-5472.c.6511541.v1
https://doi.org/10.1158/0008-5472.c.6511541.v1
Autor:
Charles W.M. Roberts, William C. Hahn, Loren D. Walensky, Kimberly Stegmaier, Peter J. Park, Prafulla C. Gokhale, Aviad Tsherniak, John M. Krill-Burger, April Cook, Katherine H. Walsh, Justin H. Hwang, Hong L. Tiv, Matthew G. Rees, Elaine M. Oberlick, Guillaume Kugener, Gregory H. Bird, Franziska Wachter, Ann M. Morgan, Minh-Tam Pham, Francisca Vazquez, Su Wang, Neekesh V. Dharia, Andrew L. Hong, Xiaofeng Wang, Andrew O. Giacomelli, Melinda R. Song, Taylor E. Arnoff, Thomas P. Howard
Expanded methodological detail on large-scale data analysis (RNAi, CRISPR-Cas9, p53 status annotations, RNA-seq, and primary tumor expression).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f609b17191e1f0d97eeabf7e23b6ca7
https://doi.org/10.1158/0008-5472.22423640
https://doi.org/10.1158/0008-5472.22423640