Zobrazeno 1 - 10
of 14
pro vyhledávání: '"M. A. Bokov"'
Publikováno v:
Nuclear Technology and Radiation Protection, Vol 36, Iss 2, Pp 107-115 (2021)
This work addresses the problem of propagating uncertainty from group-wise neutron cross-sections to the results of neutronics diffusion calculations. Automatic differentiation based on dual number arithmetic was applied to uncertainty propagation in
Autor:
I. G. Dement’yeva, P. G. Sveshnikov, L. P. Pozdnyakova, Dmitry A. Dolgikh, T. K. Aliev, M. N. Bokov, V. A. Toporova, V. V. Argentova, Yu. A. Votchitseva, Mikhail P. Kirpichnikov, S.D. Varfolomeyev
Publikováno v:
Acta Naturae. 10:30-36
We obtained recombinant variants of human antibody FI6 broadly specific to hemagglutinins of the influenza A virus. On the basis of a bi-promoter (CMV, hEF1-HTLV) vector, we developed genetic constructs for the expression of the heavy and light chain
Autor:
I. G. Dementieva, Kirpichnikov Mp, D. A. Dolgikh, V. A. Toporova, O. B. Shchemchukova, A. A. Panina, D. S. Balabashin, M. N. Bokov, P. G. Sveshnikov, L. P. Pozdnyakova, T. K. Aliev
Publikováno v:
Acta Naturae
Currently, there are no approved therapies for targeted prevention and treatment of Ebola hemorrhagic fever. In the present work, we describe the development of a eukaryotic expression system for the production of three full-length chimeric antibodie
Autor:
A. A. Panina, P. G. Sveshnikov, I. G. Dement’yeva, V. A. Toporova, Mikhail P. Kirpichnikov, M. N. Bokov, D. A. Dolgikh, L. P. Pozdnyakova, T. K. Aliev, O. B. Shemchukova
Publikováno v:
Russian Journal of Bioorganic Chemistry. 43:409-420
Previously, we have determined the nucleotide and amino acid sequences of the variable domains of three mouse monoclonal antibodies specific to the individual epitopes of the Ebola virus glycoprotein: GPE118 (IgG), GPE325 (IgM) and GPE534 (IgG) [1].
Autor:
I. G. Dement’eva, V. A. Toporova, V. V. Argentova, Dmitry A. Dolgikh, M. N. Bokov, Mikhail P. Kirpichnikov, P. G. Sveshnikov, L. P. Pozdnyakova, T. K. Aliev
Publikováno v:
Doklady Biochemistry and Biophysics. 478:34-36
We obtained dimeric forms of IgA1- and IgA2m1-isotypes of FI6 antibody broadly specific to hemagglutinins of different subtypes of influenza A virus. It was shown that the dimers of IgA1 isotype are characterized by a higher antigen-binding activity
Autor:
D. A. Dolgikh, I. G. Dement’yeva, V. S. Rybchenko, M. N. Bokov, Mikhail P. Kirpichnikov, V. A. Toporova, P. G. Sveshnikov, L. P. Pozdnyakova, T. K. Aliev
Publikováno v:
Moscow University Biological Sciences Bulletin. 71:87-92
We studied the possibility of using a broadly neutralizing anti-influenza A antibody as a module for the development of different protein constructs for diagnostics. For this purpose, we constructed two recombinant proteins—a Fab-fragment of the an
Autor:
I. G. Dement’yeva, P. G. Sveshnikov, A. A. Panina, O. B. Schemchukova, D. A. Dolgikh, M. N. Bokov, L. P. Pozdnyakova, T. K. Aliev, Mikhail P. Kirpichnikov, N. E. Varlamov
Publikováno v:
Moscow University Biological Sciences Bulletin. 71:24-28
Balb/С mice were immunized with recombinant Ebola virus glycoprotein. Following the selection, screening, and cloning of murine hybridomas, we obtained five genetically stable clones of monoclonal antibodies GPE118 (IgG), GPE274 (IgM), GPE325 (IgM),
Autor:
T K, Aliev, I G, Dement'yeva, V A, Toporova, V V, Argentova, L P, Pozdnyakova, M N, Bokov, Yu A, Votchitseva, D A, Dolgikh, S D, Varfolomeyev, P G, Sveshnikov, M P, Kirpichnikov
Publikováno v:
Acta Naturae
We obtained recombinant variants of human antibody FI6 broadly specific to hemagglutinins of the influenza A virus. On the basis of a bi-promoter (CMV, hEF1-HTLV) vector, we developed genetic constructs for the expression of the heavy and light chain
Autor:
E. V. Morozkina, O. N. Solopova, Т. А. Yagudin, N. E. Varlamov, P. G. Sveshnikov, M. N. Bokov, L. P. Pozdnyakova
Publikováno v:
Acta Naturae. 4:74-77
The peptide conformation in the context of a protein polypeptide chain is influenced by proximal amino acid residues. However, the mechanisms of this interference remain poorly understood. We studied the conformation of angiotensins 1, 2 and 3, which
Autor:
L. P. Pozdnyakova, T. K. Aliev, I. G. Dement’yeva, A. A. Panina, M. N. Bokov, P. G. Sveshnikov, O. B. Shemchukova, Mikhail P. Kirpichnikov, D. A. Dolgikh, N. E. Varlamov
Publikováno v:
Doklady. Biochemistry and biophysics. 467(1)
We determined the nucleotide and amino acid sequences of variable domains of three new monoclonal antibodies to the glycoprotein of Ebola virus capsid. The framework and hypervariable regions of immunoglobulin heavy and light chains were identified.