Risk Mitigation and Investability of a U-PHS Project in The Netherlands

Autor: Gert Jan Kramer, Twan Arts, Janos L. Urai, Han Vrijling, Jan M. H. Huynen

Publikováno v: Energies, Vol 13, Iss 19, p 5072 (2020)

We review the status of a 1.4 GW, 8 GWh underground pumped hydro storage (U-PHS) project in the southern Netherlands, which has been under development since the 1980s. Its history shows how the prospect of a large-scale U-PHS for The Netherlands (a c

Externí odkaz: https://doaj.org/article/ace2c862f5904ab4803615a144ddc9aa

Does mitochondrial DNA evolution in metazoa drive the origin of new mitochondrial proteins?

Autor: S L, van Esveld, M A, Huynen

Publikováno v: IUBMB life. 70(12)

Most eukaryotic cells contain mitochondria with a genome that evolved from their α-proteobacterial ancestor. In the course of eukaryotic evolution, the mitochondrial genome underwent a dramatic reduction in size, caused by the loss and translocation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7b438d7aa740d13ffce980bc75e71b4f
https://pubmed.ncbi.nlm.nih.gov/30281911

The effect of nasal hCT on bone turnover in Paget's disease of bone--implications for the treatment of other metabolic bone diseases

Autor: Paul Franchimont, M. Wouters, Jean-Yves Reginster, A. M. Jeugmans-Huynen, H. D. Mcintyre, N. Sarlet

Publikováno v: British journal of rheumatology. 31(1)

Thirty pagetic patients were treated for 6 months with a daily nasal application of 2 mg of synthetic human calcitonin (hCT). Serum alkaline phosphatases (SAP) and urinary hydroxyproline/creatinine ratio (OH/Cr), reflecting bone turnover, were signif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7688bf4b83c379199e497c969c5f3c
https://pubmed.ncbi.nlm.nih.gov/1730104

Biological and clinical assessment of a new bisphosphonate, (chloro-4 phenyl) thiomethylene bisphosphonate, in the treatment of Paget's disease of bone

Autor: Jean-Yves Reginster, Adelin Albert, D Denis, A. M. Jeugmans-Huynen, Paul Franchimont, Marie-Paule Lecart, Julien Collette, M. A. Fontaine, Rita Deroisy

Publikováno v: Bone. 9(6)

Several Biophosphonates have been used as therapeutic agents for Paget's bone disease. (Chloro-4 phenyl)thiomethylene-bisphosphonate (CIPsMBP) has recently been shown to have significant antiosteoclastic activity while an affect of CIPsMBP on mineral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c026bb0e2eafd30479b6b48a163129
https://pubmed.ncbi.nlm.nih.gov/3073800

CEP89 is required for mitochondrial metabolism and neuronal function in man and fly

Autor: Lillian Eshuis, Erika Viragh, Annette Schenck, Licio Collavin, Zoltan Asztalos, Bregje W.M. van Bon, Richard J. Rodenburg, Jan A.M. Smeitink, Bert B.A. de Vries, Leo G.J. Nijtmans, Patrik Verstreken, Melissa Vos, Martijn A. Huynen, Nicole de Leeuw, Mariken Ruiter, Merel A.W. Oortveld, Falko Hofmann, Michaela Fenckova, Judith A. Besseling, Lenke Asztalos, Bonnie Nijhof, Anna Castells-Nobau, Jamie M. Kramer

Publikováno v: Human Molecular Genetics, 22, 15, pp. 3138-3151
Human Molecular Genetics
Human Molecular Genetics; Vol 22
Human Molecular Genetics, 22, 3138-3151

It is estimated that the human mitochondrial proteome consists of 1000-1500 distinct proteins. The majority of these support the various biochemical pathways that are active in these organelles. Individuals with an oxidative phosphorylation disorder

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1408cbe94dde58350101a8488a9639c
http://hdl.handle.net/11368/2673331