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Autor:
Ryan W, Nelson, Yuezhou, Chen, Olivia L, Venezia, Richard M, Majerus, Daniel S, Shin, Mary N, Carrington, Xu G, Yu, Duane R, Wesemann, James J, Moon, Andrew D, Luster
Publikováno v:
Science immunology. 7(73)
CD4
Autor:
Joel Linden, Carolyn Hoppe, Brian Sheehan, Maureen Achebe, Joshua J. Field, Gene Lin, Michel Gowhari, Hillary Chu, Elaine M. Majerus, Maneka Puligandla, Victor R. Gordeuk, Alex George, Matthew M. Heeney, Donna Neuberg, David G. Nathan
Publikováno v:
Blood Advances. 1:1645-1649
Adenosine A2A receptor (A2AR) agonists have been shown to decrease tissue inflammation induced by hypoxia/reoxygenation in mice with sickle cell disease (SCD). The key mediator of the A2AR agonist's anti-inflammatory effects is a minor lymphocyte sub
Autor:
Deepika Vasudevan, Hideyuki Takeuchi, Robert S. Haltiwanger, Sumreet Singh Johar, Elaine M. Majerus
Publikováno v:
Current Biology. 25(3):286-295
Summary Background O -fucose is added to cysteine-rich domains called thrombospondin type 1 repeats (TSRs) by protein O -fucosyltransferase 2 (POFUT2) and is elongated with glucose by β3-glucosyltransferase (B3GLCT). Mutations in B3GLCT result in Pe
Autor:
Kenneth I. Ataga, Robert Mashal, Robert Schaub, David G. Nathan, Elaine M. Majerus, Joshua J. Field, E. Vichinsky
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171067 (2017)
PLoS ONE
PLoS ONE
Invariant NKT (iNKT) cells can be activated to stimulate a broad inflammatory response. In murine models of sickle cell disease (SCD), interruption of iNKT cell activity prevents tissue injury from vaso-occlusion. NKTT120 is an anti-iNKT cell monoclo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f6aabab41269342718c6b0eadd6147
Autor:
Barbara A. Konkle, Diana M Gilligan, Elynna Youm, Rajiv K. Pruthi, Lynn M. Malec, Allison P. Wheeler, Anne T. Neff, Danielle Nance, Roshni Kulkarni, Scott D. Rothenberger, Claire S. Philipp, Robert F. Sidonio, Tzu-Fei Wang, Doris M. Rubio, Glory Koerbel, Margaret V. Ragni, Nina Hwang, Elaine M. Majerus, Dana Ivanco, Andrew D. Leavitt, George M. Rodgers, Philip Kuriakose, Craig D. Seaman, Joseph Louis Lasky, Tammuella Singleton
Publikováno v:
Blood. 134:1130-1130
Background: Von Willebrand disease (VWD) is the most common inherited bleeding disorder, affecting 1% of the population, and characterized by deficient or defective von Willebrand factor (VWF). Among women with VWD, up to 80% have heavy menstrual ble
Publikováno v:
Journal of Thrombosis and Haemostasis. 7:2088-2095
Summary. Background: ADAMTS-13 proteolytic activity is controlled by the conformation of its substrate, von Willebrand factor (VWF), and changes in the secondary structure of VWF are essential for efficient cleavage. Substrate recognition is mediated
Autor:
Anthony N. Vomund, Elaine M. Majerus
Publikováno v:
Journal of Biological Chemistry. 284:30925-30932
ADAMTS13 is a plasma metalloprotease that cleaves ultralarge von Willebrand factor multimers to generate less thrombogenic fragments. Although this cleavage can occur at the surface of endothelial cells, it is currently unknown whether this process i
Autor:
Zurek, Grzegorz1 (AUTHOR) grzegorz.zurek@awf.wroc.pl, Binder, Marek2 (AUTHOR) marek.binder@uj.edu.pl, Kunka, Bartosz3 (AUTHOR) bartosz.kunka@assistech.eu, Kosikowski, Robert3 (AUTHOR) robert.kosikowski@assistech.eu, Rodzeń, Małgorzata4 (AUTHOR) malgorzata.rodzen@pcrf.pl, Karaś, Danuta4 (AUTHOR) danuta.karas@pcrf.pl, Mucha, Gabriela4 (AUTHOR), Olejniczak, Roman5 (AUTHOR) roman.olejniczak@gmail.com, Gorączko, Agata5 (AUTHOR) agagoraczko@gmail.com, Kujawa, Katarzyna5 (AUTHOR) katarzyna.kujawa@awf.wroc.pl, Stachowicz, Anna5 (AUTHOR) annimast@gmail.com, Kryś-Noszczyk, Karolina6 (AUTHOR) karolinakrysum@gmail.com, Dryjska, Joanna6 (AUTHOR) jcogiel@op.pl, Dryjski, Marcin6 (AUTHOR) marcin.dryjski@gmail.com, Szczygieł, Jarosław7 (AUTHOR) jwszczygiel@gmail.com
Publikováno v:
Journal of Clinical Medicine. Oct2024, Vol. 13 Issue 20, p6227. 16p.