Zobrazeno 1 - 10
of 54
pro vyhledávání: '"M. Gerard Waters"'
Autor:
Fumin Fu, Michael Pietropaolo, Lei Cui, Shilpa Pandit, Weiyan Li, Oleg Tarnavski, Suraj S Shetty, Jing Liu, Jennifer M Lussier, Yutaka Murakami, Prabhjit K Grewal, Galina Deyneko, Gordon M Turner, Andrew K P Taggart, M Gerard Waters, Shaun Coughlin, Yuichiro Adachi
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0256512 (2022)
The mouse is a useful preclinical species for evaluating disease etiology due to the availability of a wide variety of genetically modified strains and the ability to perform disease-modifying manipulations. In order to establish an atrial filtration
Externí odkaz:
https://doaj.org/article/9e4a05b9d5094a40b0cf21268159371c
Autor:
Alan Wise, M. Gerard Waters, Graeme Semple, Stefan Offermanns, Timothy W. Lovenberg, Adriaan P. IJzerman, Steven L. Colletti
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
The hydroxycarboxylic acid family of receptors (ENSFM00500000271913, nomenclature as agreed by the NC-IUPHAR Subcommittee on Hydroxycarboxylic acid receptors [36, 12]) respond to organic acids, including the endogenous hydroxy carboxylic acids 3-hydr
Autor:
Alison M. Strack, Ester Carballo-Jane, Sheng-ping Wang, Jiyan Xue, Xiaoli Ping, Lesley Ann McNamara, Anil Thankappan, Olga Price, Michael Wolff, T.J. Wu, Douglas Kawka, Michele Mariano, Charlotte Burton, Ching H. Chang, Jing Chen, John Menke, Silvi Luell, Emanuel I. Zycband, Xinchun Tong, Richard Raubertas, Carl P. Sparrow, Brian Hubbard, John Woods, Gary O'Neill, M. Gerard Waters, Ayesha Sitlani
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 1, Pp 177-188 (2013)
The use of nicotinic acid to treat dyslipidemia is limited by induction of a “flushing” response, mediated in part by the interaction of prostaglandin D2 (PGD2) with its G-protein coupled receptor, DP1 (Ptgdr). The impact of DP1 blockade (genetic
Externí odkaz:
https://doaj.org/article/07e92c10466c4bb5bf9831676c97ce7f
Autor:
Vincent Hernandez, Liang Liu, M. R. K. Alley, Iñigo Angulo-Barturen, Manisha Mohan, Baojie Wan, Andrés Palencia, Wai Choi, Zhenkun Ma, Lisa Feng, Scott G. Franzblau, Charles Z. Ding, Maliwan Meewan, David Barros, James C. Sacchettini, Joaquín Rullas, Paul Houston, Fernando Rock, Wei Bu, Anne J. Lenaerts, Tanya Parish, Alfonso Mendoza, Xianfeng Li, Lisa K. Woolhiser, Yasheen Zhou, M. Gerard Waters, Christopher B. Cooper, Jacob J. Plattner, Suoming Zhang, Eric E. Easom, Stephen Cusack, Veronica Gruppo, Theresa O’Malley, Holly Sexton, Esther Pérez-Herrán, Thomas R. Ioerger, Yuehong Wang
Publikováno v:
Antimicrobial Agents and Chemotherapy
'Antimicrobial Agents and Chemotherapy ', vol: 60, pages: 6271-6280 (2016)
'Antimicrobial Agents and Chemotherapy ', vol: 60, pages: 6271-6280 (2016)
The recent development and spread of extensively drug-resistant and totally drug-resistant resistant (TDR) strains of Mycobacterium tuberculosis highlight the need for new antitubercular drugs. Protein synthesis inhibitors have played an important ro
Autor:
Olga Price, Brian K. Hubbard, Ching H. Chang, Carl P. Sparrow, Jiyan Xue, Richard Raubertas, Silvi Luell, Xiaoli Ping, Alison M. Strack, Anil Thankappan, Gary P. O'Neill, Tsuei-Ju Wu, Xinchun Tong, Charlotte Burton, John G. Menke, Lesley Mcnamara, Sheng-Ping Wang, Emanuel Zycband, Jing Chen, John Woods, Douglas W. Kawka, Ester Carballo-Jane, M. Gerard Waters, Michele Mariano, Ayesha Sitlani, Michael Wolff
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 1, Pp 177-188 (2013)
The use of nicotinic acid to treat dyslipidemia is limited by induction of a "flushing" response, mediated in part by the interaction of prostaglandin D(2) (PGD(2)) with its G-protein coupled receptor, DP1 (Ptgdr). The impact of DP1 blockade (genetic
Autor:
Jerry Xu, Milton L. Hammond, Brett Lauring, James R. Tata, Philip J. Skinner, Jens Knudsen, Daniel T. Connolly, Eseng Lai, Graeme Semple, Wen-Lin Luo, M. Gerard Waters, P. Douglas Boatman, John A. Wagner, Martin C. Cherrier, Jae-Kyu Jung, Steven L. Colletti, Andrew K.P. Taggart, Ester Carballo-Jane, Ruoping Chen, Benjamin R. Johnson, Thomas O. Schrader, Josee Cote, Carleton R. Sage, Luzelena Caro, Jeremy G. Richman, Michelle Kasem, Peter J. Webb
Publikováno v:
Journal of Medicinal Chemistry. 55:3644-3666
G-protein coupled receptor (GPCR) GPR109a is a molecular target for nicotinic acid and is expressed in adipocytes, spleen, and immune cells. Nicotinic acid has long been used for the treatment of dyslipidemia due to its capacity to positively affect
Autor:
Tom G. Holt, Qi Luo, Shuo Quan, Ming-juan Luo, Heather Zhou, Kang Cheng, Neil S. Geoghagen, Lorraine Malkowitz, M. Gerard Waters, Kristian K. Jensen, Weihua Ni, Aiwu Zhang, Lan Jin
Publikováno v:
European Journal of Pharmacology. 650:86-93
Hydrogen sulfide (H(2)S) is a recently discovered gasotransmitter found in mammalian tissues and blood. Treatment with H(2)S donor molecules has shown promising results in preclinical models of inflammatory and cardiovascular diseases. Augmentation o
Autor:
Tom G. Holt, Michael Wolff, Peggy E. McCann, Silvi Lubell, M. Gerard Waters, Andrew K.P. Taggart, Mihajlo L. Krsmanovic, Abigail Lee Smenton, Steven L. Colletti, Daniel Blom, James R. Tata, Darby Schmidt, Subharekha Raghavan, Ning Ren, Tanya Ciecko, Kang Cheng, Ester Carballo-Jane, Larissa Wilsie
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4768-4772
Niacin is an effective drug for raising HDL cholesterol and reducing coronary risks, but patients show low compliance with treatment due to severe facial flushing upon taking the drug. A series of bicyclic pyrazole carboxylic acids were synthesized a
Autor:
Andrew K.P. Taggart, Abby Smenton, Steven L. Colletti, Scott Tria, Subharekha Raghavan, Sookhee Chang, M. Gerard Waters, Darby Schmidt, James R. Tata, Thomas O. Schrader, Rui Liang, Jae-Kyu Jung, Craig K. Esser, Jason E. Imbriglio, Kang Cheng, Ester Carballo-Jane
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2121-2124
5-Alkyl and aryl-pyrazole–tetrazoles have been identified as a new class of selective, small-molecule, agonists of the human G-protein-coupled receptor GPR109a, a high affinity receptor for the HDL-raising drug nicotinic acid.
Autor:
Ning Ren, Shera Kash, Samuel D. Wright, M. Gerard Waters, Kang Cheng, Lan Jin, Ruoping Chen, Andrew K.P. Taggart, Tian-Quan Cai
Publikováno v:
Biochemical and Biophysical Research Communications. 377:987-991
Heavy exercise or oxygen deficit often links with higher levels of arterial lactate and lower levels of plasma free fatty acids (FFA). Treatment with lactate reduces circulating levels of FFA in vivo and lipolysis in adipose tissues in vitro. However