Zobrazeno 1 - 10
of 266
pro vyhledávání: '"M. Ellerby"'
Autor:
Jordi Creus-Muncunill, Jean Vianney Haure-Mirande, Daniele Mattei, Joanna Bons, Angie V. Ramirez, B. Wade Hamilton, Chuhyon Corwin, Sarah Chowdhury, Birgit Schilling, Lisa M. Ellerby, Michelle E. Ehrlich
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-26 (2024)
Abstract Introduction Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the Huntingtin gene (HTT). Immune activation is abundant in the striatum of HD patients. Detection of ac
Externí odkaz:
https://doaj.org/article/b2af945c340e484f850a0185183190e3
Autor:
Kenneth A. Wilson, Sudipta Bar, Eric B. Dammer, Enrique M. Carrera, Brian A. Hodge, Tyler A. U. Hilsabeck, Joanna Bons, George W. Brownridge, Jennifer N. Beck, Jacob Rose, Melia Granath-Panelo, Christopher S. Nelson, Grace Qi, Akos A. Gerencser, Jianfeng Lan, Alexandra Afenjar, Geetanjali Chawla, Rachel B. Brem, Philippe M. Campeau, Hugo J. Bellen, Birgit Schilling, Nicholas T. Seyfried, Lisa M. Ellerby, Pankaj Kapahi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Dietary restriction (DR) delays aging, but the mechanism remains unclear. We identified polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd expression in response to DR. Knockdown in adulthood inhibited DR-mediat
Externí odkaz:
https://doaj.org/article/3db7a1cee89643b094c27462834817ac
Autor:
Kizito-Tshitoko Tshilenge, Joanna Bons, Carlos Galicia Aguirre, Cristian Geronimo-Olvera, Samah Shah, Jacob Rose, Akos A. Gerencser, Sally K. Mak, Michelle E. Ehrlich, D. Cristopher Bragg, Birgit Schilling, Lisa M. Ellerby
Publikováno v:
Neurobiology of Disease, Vol 190, Iss , Pp 106367- (2024)
Summary: X-linked dystonia-parkinsonism (XDP) is a rare neurodegenerative disease endemic to the Philippines. The genetic cause for XDP is an insertion of a SINE-VNTR-Alu (SVA)-type retrotransposon within intron 32 of TATA-binding protein associated
Externí odkaz:
https://doaj.org/article/297c02029d604c4fb715e2e69b76c9cc
Autor:
Matan Sorek, Walaa Oweis, Malka Nissim-Rafinia, Moria Maman, Shahar Simon, Cynthia C. Hession, Xian Adiconis, Sean K. Simmons, Neville E. Sanjana, Xi Shi, Congyi Lu, Jen Q. Pan, Xiaohong Xu, Mahmoud A. Pouladi, Lisa M. Ellerby, Feng Zhang, Joshua Z. Levin, Eran Meshorer
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-25 (2021)
Abstract Background Many neurodegenerative diseases develop only later in life, when cells in the nervous system lose their structure or function. In many forms of neurodegenerative diseases, this late-onset phenomenon remains largely unexplained. Re
Externí odkaz:
https://doaj.org/article/ef6b9f08c22b4b3bb7ae4a84695c552b
Autor:
Maria-Daniela Cirnaru, Sicheng Song, Kizito-Tshitoko Tshilenge, Chuhyon Corwin, Justyna Mleczko, Carlos Galicia Aguirre, Houda Benlhabib, Jaroslav Bendl, Pasha Apontes, John Fullard, Jordi Creus-Muncunill, Azadeh Reyahi, Ali M Nik, Peter Carlsson, Panos Roussos, Sean D Mooney, Lisa M Ellerby, Michelle E Ehrlich
Publikováno v:
eLife, Vol 10 (2021)
Many diseases are linked to dysregulation of the striatum. Striatal function depends on neuronal compartmentation into striosomes and matrix. Striatal projection neurons are GABAergic medium spiny neurons (MSNs), subtyped by selective expression of r
Externí odkaz:
https://doaj.org/article/301679f6c49048c8a4afba920502c74a
Autor:
Sicheng Song, Jordi Creus Muncunill, Carlos Galicia Aguirre, Kizito-Tshitoko Tshilenge, B. Wade Hamilton, Akos A. Gerencser, Houda Benlhabib, Maria-Daniela Cirnaru, Mark Leid, Sean D. Mooney, Lisa M. Ellerby, Michelle E. Ehrlich
Publikováno v:
Biomedicines, Vol 10, Iss 10, p 2377 (2022)
The dysregulation of striatal gene expression and function is linked to multiple diseases, including Huntington’s disease (HD), Parkinson’s disease, X-linked dystonia-parkinsonism (XDP), addiction, autism, and schizophrenia. Striatal medium spiny
Externí odkaz:
https://doaj.org/article/4bd87685543d46c2b0b873499ca2ac64
Autor:
Charles A. Schurman, Jordan B. Burton, Jacob Rose, Lisa M. Ellerby, Tamara Alliston, Birgit Schilling
Publikováno v:
Journal of Bone Metabolism. 30:1-29
Molecular omics technologies, including proteomics, have enabled the elucidation of key signaling pathways that mediate bidirectional communication between the brain and bone tissues. Here we provide a brief summary of the clinical and molecular evid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a33f9bb17cb5ebc0d4dd89baa5001997
https://doi.org/10.11005/jbm.2023.30.1.1
https://doi.org/10.11005/jbm.2023.30.1.1
Autor:
Rui Gao, Anirban Chakraborty, Charlene Geater, Subrata Pradhan, Kara L Gordon, Jeffrey Snowden, Subo Yuan, Audrey S Dickey, Sanjeev Choudhary, Tetsuo Ashizawa, Lisa M Ellerby, Albert R La Spada, Leslie M Thompson, Tapas K Hazra, Partha S Sarkar
Publikováno v:
eLife, Vol 8 (2019)
How huntingtin (HTT) triggers neurotoxicity in Huntington’s disease (HD) remains unclear. We report that HTT forms a transcription-coupled DNA repair (TCR) complex with RNA polymerase II subunit A (POLR2A), ataxin-3, the DNA repair enzyme polynucle
Externí odkaz:
https://doaj.org/article/868605a660db461085d000609c271e4b
Autor:
Carlos Galicia Aguirre, Kizito-Tshitoko Tshilenge, Elena Battistoni, Alejandro Lopez-Ramirez, Swati Naphade, Kevin Perez, Sicheng Song, Sean D. Mooney, Simon Melov, Michelle E. Ehrlich, Lisa M. Ellerby
SUMMARYHuntington’s disease (HD) is a neurodegenerative disorder caused by an expansion of CAG repeats in exon 1 of theHTTgene, ultimately resulting in the generation of a mutant HTT (mHTT) protein. Although mHTT is expressed in various tissues, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2bf30d3828038869b311787fb28c25a
https://doi.org/10.1101/2023.04.30.538872
https://doi.org/10.1101/2023.04.30.538872
Autor:
Narges Asefifeyzabadi, Grace Durocher, Kizito-Tshitoko Tshilenge, Tanimul Alam, Lisa M. Ellerby, Mohtashim H. Shamsi
Publikováno v:
RSC Advances. 12:7757-7761
We present a PNA microprobe sensing platform to detect trinucleotide repeat mutation by electrochemical impedance spectroscopy. The microprobe platform discriminated Huntington's disease-associated CAG repeats in cell-derived total RNA with S/N 1 : 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717914b6405382661c2e610cf3d1f172
https://doi.org/10.1039/d2ra00230b
https://doi.org/10.1039/d2ra00230b