Zobrazeno 1 - 10
of 1 139
pro vyhledávání: '"M-current"'
Publikováno v:
Frontiers in Neural Circuits, Vol 17 (2023)
Conductance-based models have played an important role in the development of modern neuroscience. These mathematical models are powerful “tools” that enable theoretical explorations in experimentally untenable situations, and can lead to the deve
Externí odkaz:
https://doaj.org/article/9ee3d4f4d820464e90df4009e14b18b0
Akademický článek
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Autor:
Han-Xiong Bear Zhang, Laurel Heckman, Zachary Niday, Sooyeon Jo, Akie Fujita, Jaehoon Shim, Roshan Pandey, Hoor Al Jandal, Selwyn Jayakar, Lee B Barrett, Jennifer Smith, Clifford J Woolf, Bruce P Bean
Publikováno v:
eLife, Vol 11 (2022)
Cannabidiol (CBD), a chemical found in the Cannabis sativa plant, is a clinically effective antiepileptic drug whose mechanism of action is unknown. Using a fluorescence-based thallium flux assay, we performed a large-scale screen and found enhanceme
Externí odkaz:
https://doaj.org/article/e58eafd704e84f2b9bdbc4303277ac23
Autor:
Qin Yang, Qing Qing Tan, Chang Jun Lan, Bo Zhen Lv, Gui Mei Zhou, Wei Qi Zhong, Zhi Ming Gu, Yu Mei Mao, Xuan Liao
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
KCNQ5 is suggestively associated with myopia, but its specific role in the myopic process has not been studied further. The aim of this study was to investigate the expression of potassium channel gene KCNQ5 and the changes of K+ microenvironment wit
Externí odkaz:
https://doaj.org/article/3909b3eefd4945f889f2f1ba203246fc
Autor:
T. Bayasgalan, S. Stupniki, A. Kovács, A. Csemer, P. Szentesi, K. Pocsai, L. Dionisio, G. Spitzmaul, B. Pál
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
The pedunculopontine nucleus (PPN), a structure known as a cholinergic member of the reticular activating system (RAS), is source and target of cholinergic neuromodulation and contributes to the regulation of the sleep–wakefulness cycle. The M-curr
Externí odkaz:
https://doaj.org/article/0351a4a655394e78bc2703895cd8a541
Structural basis and energy landscape for the Ca 2+ gating and calmodulation of the Kv7.2 K⁺ channel
Autor:
Bernardo-Seisdedos, Ganeko, Nuñez, Eider, Gomis-Perez, Carolina, Malo, Covadonga, Villarroel, Álvaro, Millet, Oscar
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2018 Mar 01. 115(10), 2395-2400.
Externí odkaz:
https://www.jstor.org/stable/26507850
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
The pre-Bötzinger complex (preBötC) of the ventral medulla generates the mammalian inspiratory breathing rhythm. When isolated in explants and deprived of synaptic inhibition, the preBötC continues to generate inspiratory-related rhythm. Mechanism
Externí odkaz:
https://doaj.org/article/c73d03ece89c41cd9911432514397d9f
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Dorsal and median raphe nuclei (DR and MR, respectively) are members of the reticular activating system and play important role in the regulation of the sleep-wakefulness cycle, movement, and affective states. M-current is a voltage-gated potassium c
Externí odkaz:
https://doaj.org/article/21c24222cc974f5ebc2e204ed6bbe49c
Autor:
Dina Simkin, Kelly A Marshall, Carlos G Vanoye, Reshma R Desai, Bernabe I Bustos, Brandon N Piyevsky, Juan A Ortega, Marc Forrest, Gabriella L Robertson, Peter Penzes, Linda C Laux, Steven J Lubbe, John J Millichap, Alfred L George Jr, Evangelos Kiskinis
Publikováno v:
eLife, Vol 10 (2021)
Mutations in KCNQ2, which encodes a pore-forming K+ channel subunit responsible for neuronal M-current, cause neonatal epileptic encephalopathy, a complex disorder presenting with severe early-onset seizures and impaired neurodevelopment. The conditi
Externí odkaz:
https://doaj.org/article/77a9457c95724ba991f9276aa4d1ab55
Akademický článek
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